Insulin resistance good on hypocaloric diet???!!!

[plornive]

I have seen on two occasions Dan Duchaine writing that the insulin resistance that comes with ECA and clen usage is good on a hypocaloric diet and promotes fat utilization. Does this make sense?

My only explanation: by denying muscle cells the ability to utilize glycogen, they are forced to burn fat. Since it is a hypocaloric diet, blood glucose decreases even with insulin resistance --- it goes to the liver (but since it is hypocaloric it does not spill over).

Does this make sense or is Dan Duchaine blatantly wrong? By the way, if you didn't know ECA causes slight insulin resistance during usage, it does.

 

[Anatomywiz]

For health reasons, insulin resistance is obviously not good, sugar build-up in the blood,etc. However for fat loss Dan would be correct. If the body cannot use some of the calories is is getting in the form of carbohydrates, it will instead favor fat metabolism. This is shown when you look at The respiratory quotient of a person after a meal. A RQ of 1.0=approx 100% carb utilization, 7.0=approx. 100% fat utilization, and .85=50/50. If you eat a meal that is higher in fats you will see a lower RQ, and visa versa. So in this case if the person is not shuttling the carbs into the cells the body will increase fat use instead for energy. In individuals with adult onset diabetes there is often extremely high blood sugar, while at the same time they are producing ketone bodies. I assume the extra carbs in the blood that aren't taken up by the body will be eventually flushed out in the urine, as happens with diabetics.

 

[Jacob Creutzfeldt]

If fat cells become insulin resitant disporpotionally greater than lean tissue cells it could be helpful for dieting.

 

[plornive]

If fat cells become insulin resitant disporpotionally greater than lean tissue cells it could be helpful for dieting.

You bring up an interesting point. ECA may actually downregulate muscle GLUT-4 more than adipocyte GLUT-4! I think both are downregulated because of higher fatty acid mobilization, but muscle GLUT-4 is downregulated even further because of less ATP depletion while working out. Brian Haycock has an article on this. It is about clenbuterol, but he mentions it is the same with ECA.

Anyway, I think the positives may outweigh the negatives on a caloric deficit.