IGF-1 and GH might produce more favorable results than either one along
While it is clear that exogenous GH increased IGF-1 levels.
And while it is clear that IGF-1 is beneficial for fat loss (directly and indirectly)
It is far from being conclusive to say that GH positive effect on fat loss is ONLY due to
increased IGF-1 levels. There may be other mechanisms through which GH may prove beneficial for fat loss.
Intrestingly, one study showed GH administration ALONG with IGF-1 proved more beneficial than either one of them given alone.
"GH and IGF-I given together may enhance fat loss over either given alone."
Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese
postmenopausal women. Journal of Clinical Endocrinology Metabolism. 1998 May. Geriatric Research Education and Clinical Center and Medical Service, Veterans Affairs Health Care System.
To determine the effects of GH and insulin-like growth factor I (IGF-I) administration, diet, and exercise on weight loss, body composition, basal metabolic rate (BMR), muscle strength, and psychological status, 33 moderately obese postmenopausal women (67.1 +/- 5.2 yr) participated in a 12-week randomized, double blind study. Participants were placed on a diet that provided 500 Cal/day less than that needed or weight maintenance, and they walked 3 days and strength trained 2 days each week. ubjects also self-injected GH (0.025 mg/kg BW.day), IGF-I (0.015 mg/kg BW.day), a combination of these doses of GH and IGF-I, or placebo (P). Twenty-eight women completed the study, as five subjects dropped out due to intolerable side-effects (e.g. edema). Weight loss occurred in all groups, with the largest decrease occurring in the GH plus IGF-I group (5.6 +/- 1.4 kg). Fat mass significantly decreased in all groups, with the largest losses observed in GH and GH plus IGF-I groups (6.3 +/- 1.8 and 8.4 +/- 2.8 kg, respectively). Despite weight loss, BMR was maintained in all groups. Muscle strength increased with training for all groups, and depression and anxiety scores decreased in groups receiving IGF-I. These data show that obese postmenopausal women can lose weight and fat without compromising fat free mass, BMR, or gains in muscle strength, and that GH and IGF-I given together may enhance fat loss over either given alone.
Regarding dosages for IGF-1, I'd hate to say that the companies selling IGF-1 hide the fact that IGF-1 is probably mutely beneficial at the dosages that people can afford buying IGF-1. For example, the mentioned study above used the following dosages:
GH (0.025 mg/kg BW.day)
IGF-1 (0.015 mg/kg BW.day)
That would translate to an individual weighting 190 pounds (86kg) to use:
2.15mg (8.6iu GH every day) and 1290mcg (!!!!) of IGF-1 everyday.
In another study published 1996 January Division of Endocrinology, Charles A. Dana Research Institute, Harvard-Thorndike Laboratories. The participans used 100mcg/kg bw translating to 8600mcg a day for our individual. I should note that it is unclear which IGF-I brand and type was used in both studies. I've also seen people report IGF-1 levels still within normal range when they inj 50mcg of IGF-1 everyday. To achieve the great results of fat loss and/or mass gain supraphysiological dosages, and i'm talking of real supraphysiological dosages of IGF-1 and GH should be used, and that
is far from the dosage regimn most follow.
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