hyperplasia question

[Zander1983]

I'm definately no expert in muscle physiology, but for somebody of your age, it could be possible.

 

[jeremys]

could a person hypothetically be in a caloric deficit yet experience gains in hyperplasia? i'm not finding much info on this kind of stuff..just curious

 

[casualbb]

I think hyperplasia whether on a caloric surplus or deficit is pretty low unless you're on the juice...

From the HST FAQ:

J Appl Physiol. 1993 Apr;74(4):1893-8.
"Title: Effects of anabolic steroids on the muscle cells of strength-trained athletes.

Researchers: Kadi F, Eriksson A, Holmner S, Thornell LE Department of Integrative Medical Biology, Umea University, Sweden.

Source: Med Sci Sports Exerc 1999 Nov;31(11):1528-34

Summary:

Athletes who use anabolic steroids get larger and stronger muscles. How this is reflected at the level of the muscle fibers has not yet been established and was the topic of this investigation. METHODS: Muscle biopsies were obtained from the trapezius muscles of high-level power lifters who have reported the use of anabolic steroids in high doses for several years and from high-level power lifters who have never used these drugs. Enzyme-immunohistochemical investigation was performed to assess muscle fiber types, fiber area, myonuclear number, frequency of satellite cells, and fibers expressing developmental protein isoforms.

RESULTS: The overall muscle fiber composition was the same in both groups. The mean area for each fiber type in the reported steroid users was larger than that in the nonsteroid users (P < 0.05). The number of myonuclei and the proportion of central nuclei were also significantly higher in the reported steroid users (P < 0.05). Likewise, the frequency of fibers expressing developmental protein isoforms was significantly higher in the reported steroid users group (P < 0.05). [these researchers found embryonic fiber development in the nonsteroid using group as well...just not as much as in the group using.]

CONCLUSION: Intake of anabolic steroids and strength-training induce an increase in muscle size by both hypertrophy and the formation of new muscle fibers (hyperplasia). We propose that activation of satellite cells is a key process and is enhanced by the steroid use. The incorporation of the satellite cells into preexisting fibers to maintain a constant nuclear to cytoplasmic ratio seems to be a fundamental mechanism for muscle fiber growth. Although all the subjects in this study have the same level of performance, the possibility of genetic differences between the two groups cannot be completely excluded.

-casualbb

 

[jeremys]

thanks. karma

 

[Lord_Suston]

most biologist advocate that humans under normal onditions of stress will not undergo hyperplasia but hypertrophy.... Except the tras and delt areas. For some weird unknown reason these muscle are able to gain tissue over time in athletes wether they juice or not.

At your age I would think you might still have a chance for hyperplasia because your bones are not fully calcified hence the growth of theses bones would create a growth in muscle fiber to accomodate new bone material. Most of this is based on growth studies though

 

[casualbb]

Thanks, jeremy

It's interesting that you should bring up that point, suston. I posted in another thread...I know for a fact that traps and delts have the highest number of androgen receptors per muscle fiber of the body. Which would make them more susceptible to natural testosterone. So there could be a steriod-like effect in them, perhaps?

-casualbb

 

[Lord_Suston]

Thanks, jeremy

It's interesting that you should bring up that point, suston. I posted in another thread...I know for a fact that traps and delts have the highest number of androgen receptors per muscle fiber of the body. Which would make them more susceptible to natural testosterone. So there could be a steriod-like effect in them, perhaps?

-casualbb

maybe but most studies showed it was the type of activity that made hyperplasia possible. FAst and explosive movements repeated cause the most splitting and growth.

 

[coolcolj]

maybe but most studies showed it was the type of activity that made hyperplasia possible. FAst and explosive movements repeated cause the most splitting and growth.

hmmm olylifts

 

[bigstve12]

This is an interesting thread. I didnt know the adult body experienced any hyperplasia, except for cancer of course. When Im at school ill do a more detailed search and post anything interesting I find. Hey Suston, what are you studying at school?

 

[collegiateLifter]

This is an interesting thread. I didnt know the adult body experienced any hyperplasia, except for cancer of course.

Well there is no direct evidence that i'm aware of showing hyperplasia, only indirect, observational studies like casual cited.

 

[bignate73]

hmmm olylifts

yeah yeah yeah!

 

[casualbb]

Well there is no direct evidence that i'm aware of showing hyperplasia, only indirect, observational studies like casual cited.

He's completely right, it's all speculative. There's actually a giant debate on the HST forums about hyperplasia, good info...

http://www.hypertrophy-specific.com/cgi-bin/ib3/ikonboard.cgi?;act=ST;f=2;t=884

-casualbb

 

[jeremys]

so what do i do? lift normally and stretch my ass off?

 

[The Red Dragon]

Intesting stuff. Heh makes me glad I'm still 17.