Huck Why Nolvadex, Not Clomid Post Cycle???

[Texas Ranger]

Huck, why are guys recommending Nolvadex post cycle to get Test levels up rather than Clomid? I thought Clomid was a staple post cycle. I think AS Guru, Bill Roberts was the first to recommend this. But why?? Is it REALLY better than Clomid??

 

[Zyglamail]

Many people believe Nolva to be a more powerfull product at binding to the ER, other still think clomid is superior because its beleived to have better binding characteristics in the petuitary.

 

[FISHTALES]

why not both?

 

[HUCKLEBERRY FINNaplex]

They both work through primarily the same mechanisms.They are selective estrogen receptor modulators(SERMs).They are both mixed agonists/antagonists.BUT-I believe that they both have strengths,as well as weaknesses.Nolvadex's strength is undoubtedly its ability to act as an anti-E in mammary tissue.Despite it being an old drug,it may very well still be the best out there for this specific purpose.Nolvadex does have some E blocking capabilities at the hypothalamus,which would give it the ability to catalyze the initialization of testosterone through an increase in gonadotropin-releasing hormone(GnRH).I do however feel that clomid does this even better,as well as it has the ability to bind more strongly to the pituitary and directly cause it to release the secondary(and perhaps most important)hormone in T production-Leutenizing hormone(LH).For this reason,I feel that clomid is a better choice for post-cycle T recovery.

 

[gearedup50]

When I came off cycle last time I had been on for 3 years without a break and I took 2 weeks of HCG right at the end then I took nolvadex, arimidex AND clomid and I had my balls and sex drive back in a little less than 6 weeks! Probably no need for all that as I am sure it was overkill but in my case so was the 3 year cycle!

 

[jsn]

what about the question of using both nolva and clomid together ?? could this be better in restoring T levels vs. clomid alone ??

jsn

 

[projection]

When I came off cycle last time I had been on for 3 years without a break and I took 2 weeks of HCG right at the end then I took nolvadex, arimidex AND clomid and I had my balls and sex drive back in a little less than 6 weeks! Probably no need for all that as I am sure it was overkill but in my case so was the 3 year cycle!

now thats a looooooong cycle

 

[stealth]

Great question. I'd like to hear responeses re: clomid plus nolvadex.

 

[Zyglamail]

Great question. I'd like to hear responeses re: clomid plus nolvadex.

Huck pretty much allready answered it. If clomid binds to the petuitary better than nolva, then why would you need nolva and clomid if recovery is the goal?

 

[nandi12]

I would be surprised if there were any synergism between clomid and nolva.

Clomid is a "racemic' mixture of two isomers of a compound, enclomiphene and zuclomiphene, whereas nolva consists of the single isomer enclomiphene.

Enclomiphene is an antiestrogen, while zuclomiphene is estrogenic. The body metabolizes both isomers into compounds that have even greater affinities (100 fold) for the estrogen receptor.

The body also has enzymes called isomerases that can convert the metabolites back and forth into each other. So no matter which drug one takes, there will always be a combination of estrogens and antiestrogens in the circulation.

One study found that 20mg of nolvadex was equivalent to 150mg of clomid in raising LH levels in men. (1)

(1)Fertil Steril 1978 Mar;29(3):320-7 ,

Hormonal effects of an antiestrogen, tamoxifen, in normal and oligospermic men.

Vermeulen A, Comhaire F.

 

[Texas Ranger]

So basically, stick with Clomid and Arimidex for post cycle recovery, right?

 

[Zyglamail]

So basically, stick with Clomid and Arimidex for post cycle recovery, right?

Yup

 

[LONE_AZ]

You would only need to take b.oth if you are concerned with GYNO post cycle. Clomid does not bind have the same binding potential to breast tissue as Nolvaldex. So for those prone to gyno it is a good idea to take both post cycle..

 

[Texas Ranger]

Up again!!

 

[Texas Ranger]

Opinions on Nolvadex and Arimidex post cycle. Good idea???

 

[XBiker]

Opinions on Nolvadex and Arimidex post cycle. Good idea???

How many time must you hear it?

The recommendation is to take arimidex throughout your post cycle CLOMID therapy. Save the nolva in case you need it.

 

[bigdelt69]

so basicly i gather that unless you are getting or have gyno, clomid and liquidex are all that needed, but one should allways have nolva on hand just in case.

 

[DrJMW]

When I came off cycle last time I had been on for 3 years without a break and I took 2 weeks of HCG right at the end then I took nolvadex, arimidex AND clomid and I had my balls and sex drive back in a little less than 6 weeks! Probably no need for all that as I am sure it was overkill but in my case so was the 3 year cycle!

All you needed was the HCG and Nolvadex.