Depending upon the response, I will do 1000iu EOD until they are back. I have used a second 5000iu amp the same way after a week or so if I am not happy with the recovery. The stuff works right away, day after first shot you will notice. Some people get gyno from doses over 1000iu at one time but it is real individual and if you use the Nolva at the same time you will be ok.