If you are considering doing GH, first you should make sure that you have enough for atleast a minimum of 12 weeks, anything less will be a waste. For good results, take 4 i.u.'s a day 5 days on 2 days off, not 3 days a week like mentioned before. Take 2 i.u.'s in the morning and 2 i.u.'s in the evening. I would not take it while you sleep because that is when you produce your own GH, so why interfere with your own production, I would take it way before I go to sleep so that way you can get the benefit of your GH injections and your natural GH during sleep. It should be taken with gear to really get good results otherwise you will just be burning fat. I would also take it with insulin. That is up to you. But GH puts alot of stress on your pancreas to produce insulin and your body becomes insulin resistant, and you can turn yourself into a diabetic if insulin shots are not taken, but when taking insulin you must be extremely careful as you can put yourself in a coma or even die if not done right. If using insulin get Humalog or Humulin-R, they are fast acting and that is the kind you need, not the slow releasing kind. If you are going to take insulin make sure you get info on how to do it otherwise you can screw yourself up. Email me if you need info on how to do this. But the insulin is what makes the difference between the average guy taking GH to get big and the bodybuilder look. Body builers take insulin because it easily puts on 20 or more pounds of ripped muscle when done right. YOu have to make sure you dont take the insulin at the same time as the GH and that you eat 10 grams of high glycemic carbs for every I.U. of insulin injected. If you decide to take insulin with Gh and gear the results will be the best you have ever seen. Good Luck