it depends alot on the quality of the gh. pharma 2 iu will be good. chinese shit maybe 6-8. 4 is pretty standard for ugl. for me at 5 iu about an 30/60 min after an IM inject i feel really good and happy, full of energy. then it wears off after another hour or 2, and i could sleep on a dime. very little carpal tunnel, and all other aches and joint pains go away. ive had 3 different joint surgeries, one dislocated hip, and almost a shoulder surgery... everything feels so good. i never really timed it, but a couple weeks id say and at 6iu i started to get really bad carpal tunnel in my wrists. i never had any other bad effects that i can recall, well i fell asleep anywhere instantly if i was sitting down.. including work, but thats what i used to gauge my usage was carpal pain.