HGH Causes Diabetes?

[danymal04]

HGH implicated bodybuilder's diabetes

Reported here in Newswise, the British Journal of Sports Medicine has published a case of a body builder suffering complications from HGH/steroid/insulin use.

The bodybuilder complained of severe chest pain, apparently from complications of diabetes. Next time it will be from his cardiac hypertrophy.

Newswise — Use of growth hormone to boost athletic performance can lead to diabetes, reports a study published ahead of print in the British Journal of Sports Medicine.

The study reports the case of a 36 year old professional body-builder who required emergency care for chest pain.

He had lost 40 kg in 12 months, during which he had also experienced excessive urination, thirst, and appetite.

He admitted to using anabolic steroids for 15 years and artificial growth hormone for the past three. He had also taken insulin, a year after starting on the growth hormone.

This was done to counter the effects of high blood sugar, but he had stopped taking it after a couple of episodes of acute low blood sugar (hypoglycaemia) while at the gym.

Tests revealed that his liver was inflamed, his kidneys were enlarged and that he had very high blood sugar. He was also dehydrated, and diagnosed with diabetes.

He was given intravenous fluids and gradually increasing amounts of insulin over five days, after which he was discharged. His symptoms completely cleared up, and he was no longer diabetic.

The use of growth hormone has steadily risen among amateur athletes and bodybuilders all round the world, say the authors, because it is easy to buy online and difficult to detect in screening tests—unlike anabolic steroids.

The authors believe that this is the first reported case of diabetes associated with the use of high dose growth hormone, and urge anyone taking high doses to regularly check their blood sugar levels.

Click here to view the paper in full: http://press.psprings.co.uk/bjsm/february/sm30585.pdf

 

[jmead]

bump..

anyone have any arguments towards this?

 

[ricorico]

i probably wouldve blamed his insulin usage before id blame the GH

 

[Cauliflower Ear]

yeah...why would gh do it...fuckin slin would be fucking with your natural amounts of insulin in your body and would cause it no?

 

[tin2]

Maybe he was prone to diabetes and the gh sped it up.?

 

[Magick69]

HGH implicated bodybuilder's diabetes

Reported here in Newswise, the British Journal of Sports Medicine has published a case of a body builder suffering complications from HGH/steroid/insulin use.

The bodybuilder complained of severe chest pain, apparently from complications of diabetes. Next time it will be from his cardiac hypertrophy.

Newswise — Use of growth hormone to boost athletic performance can lead to diabetes, reports a study published ahead of print in the British Journal of Sports Medicine.

The study reports the case of a 36 year old professional body-builder who required emergency care for chest pain.

He had lost 40 kg in 12 months, during which he had also experienced excessive urination, thirst, and appetite.

He admitted to using anabolic steroids for 15 years and artificial growth hormone for the past three. He had also taken insulin, a year after starting on the growth hormone.

This was done to counter the effects of high blood sugar, but he had stopped taking it after a couple of episodes of acute low blood sugar (hypoglycaemia) while at the gym.

Tests revealed that his liver was inflamed, his kidneys were enlarged and that he had very high blood sugar. He was also dehydrated, and diagnosed with diabetes.

He was given intravenous fluids and gradually increasing amounts of insulin over five days, after which he was discharged. His symptoms completely cleared up, and he was no longer diabetic.

The use of growth hormone has steadily risen among amateur athletes and bodybuilders all round the world, say the authors, because it is easy to buy online and difficult to detect in screening tests—unlike anabolic steroids.

The authors believe that this is the first reported case of diabetes associated with the use of high dose growth hormone, and urge anyone taking high doses to regularly check their blood sugar levels.

Click here to view the paper in full: http://press.psprings.co.uk/bjsm/february/sm30585.pdf

thanks bro but nothing new that was the reason why i have never thought of using it

 

[ricorico]

thanks bro but nothing new that was the reason why i have never thought of using it

GH causing diabetes is not new news to you??

 

[bbkingpin]

I experienced low blood sugar from hGH. I've never taken exogenous insulin.

 

[CO B-man]

i probably wouldve blamed his insulin usage before id blame the GH

100% exactly what I was thinking but who knows for sure! You can really screw up your body using insulin wrong but I suppose you could with using any of the stuff we do wrong.

 

[D_Mac]

I experienced low blood sugar from hGH. I've never taken exogenous insulin.

Thats interesting, I've never heard of that one either. It does seem quite a bit more intuitive that the insulin use would be to blame. Maybe one of our house Chemists will give us an explanation?

Ulter?
PP?
Medical?

 

[CO B-man]

I experienced low blood sugar from hGH. I've never taken exogenous insulin.

Can you just counteract that with sugar? Just eating a candy bar or something? Can you buy tests OTC to test your blood sugar levels?

 

[Magick69]

GH causing diabetes is not new news to you??

nope mate when i did a research to find out which gear was not bad for the hair; i read lots about GH so i was very happy about it and started to research about side effects and this came out so i left it

nothing new...

Study suggests growth hormone may precipitate diabetes in children
Treatment with growth hormone may accelerate the development of type 2 diabetes in predisposed children and adolescents, say researchers.
A retrospective analysis of a Pharmacia and Upjohn database that monitors the safety of growth hormone therapy in children and adolescents was conducted by Dr Wayne Cutfield (department of paediatrics, University of Auckland, New Zealand) and colleagues. Of 23,333 children, 43 were found to have a confirmed glucose disorder - diabetes type 1 or 2, or impaired glucose tolerance. Of these, the incidence of type 2 diabetes was found to be six times greater than expected, with 18 children affected. However, the incidence of type 1 diabetes was not higher than expected.
In children who developed type 2 diabetes, the condition continued after discontinuation of growth hormone therapy, which excluded a transient drug-induced effect, the researchers say. Dr Cutfield et al comment that growth hormone is known to contribute to insulin resistance and that there are several sites in the insulin-signalling pathway at which growth hormone could induce anti-insulin effects. However, they say: "We speculate that conventional growth hormone therapy alone is unlikely to initiate a new case of diabetes mellitus." Some children receiving growth hormone may be at a higher risk of developing diabetes because they have other conditions, such as Turner's syndrome, they suggest.
The researchers advise that, before growth hormone therapy is begun, a child's glucose status should be measured and the patient should be followed up (Lancet 2000;355:610).
In a leading article commenting on the paper (ibid, p589), Dr William Jeffcoate (department of diabetes and endocrinology, City hospital, Nottingham) discusses the relevance to adults receiving treatment with growth hormone. He says that the results cannot be directly extrapolated. Much larger doses of growth hormone are used in children, he says, so the risk of diabetes in adults could be even less than that reported in the study. However, there is still "cause for concern". Dr Jeffcoate says that a large-scale, long-term, prospective study is needed to determine the efficacy and safety of growth hormone therapy.

=====================================================

Horm Res. 1993;40(1-3):68-79. Links
Growth hormone and diabetes mellitus. A review of sixty-three years of medical research and a glimpse into the future?Sonksen PH, Russell-Jones D, Jones RH.
Department of Endocrinology and Chemical Pathology, United Medical School, Guy's Hospital, London, UK.

The diabetogenic action of pituitary extracts containing growth hormone has been recognised for more than 60 years and the importance of growth hormone in the development and progression of diabetic retinopathy for more than 30 years. Hypophysectomy was the first effective treatment for retinopathy but was discontinued because of the risk of severe hypoglycaemia that it produced and the development of an alternative, less dangerous therapy--photocoagulation. The precise role and significance of growth hormone in diabetes care, however, remains to this day a mystery. The fact that modern, highly purified biosynthetic preparations of growth hormone still retain full diabetogenic potency and the fact that diabetes develops in up to 25% of patients with acromegaly indicate growth hormone's potential for involvement in the aetiology of diabetes mellitus, although most will agree that this is not likely to be an important factor in the large majority of 'idiopathic' cases. There is strong evidence to indicate a substantial hypersecretion of growth hormone in 'idiopathic' diabetes mellitus (particularly insulin-dependent cases and those with retinopathy), which appears to be more related to residual pancreatic insulin secretion than to metabolic control. Since the advent of biosynthetic growth hormone in sufficient quantity to perform trials in adults, we are more aware of growth hormone's considerable potency in the regulation of body composition, growth factor production and intermediary metabolism. In this article, we review the literature and, from this and our own work, propose a new hypothesis which links the hypersecretion of growth hormone to reduced hepatic secretion of insulin-like growth-factor I (IGF-I) as a direct result of reduced portal insulin levels in diabetes mellitus. The hypersecretion of growth hormone exposes peripheral organs such as the retina and kidney to conditions favouring the expression of growth-hormone-dependent growth factors such as IGF-I which may contribute to the development of diabetic microvascular disease by autocrine and/or paracrine effects. If this hypothesis proves to be true, it offers new opportunities for the prevention of diabetic microvascular complications through suppression of growth hormone secretion which in turn will increase insulin sensitivity and facilitate good glycaemic control.

actually to be precise not only GH but IGF-1 and insulin all have strong links to the development of diabetes Obviously people like me that have a family history of diabetes should not even think of using them

 

[trez]

I would suggest that this side effect of HGH use is to be expected, but rare.

I don't believe the mechanism is understood even these days, but a casual link between the use of HGH and acromegaly(adults) and gigantism(developed pre-puberty) is not too much of a shot in the dark.

Acromegaly/gigantism is hypersecretion of Growth Hormone, usually caused by a GH secreting tumor on the anterior pituitary (I'm pretty sure that's where it is but I'm not wiki-checking right now). A large percentage (much larger than the general population) of sufferers of these diseases develop type 2 diabetes.

Summary:

The connection? If people who naturally have too much GH in their system are more likely to have diabetes, I would suggest that whatever the mechanism, that artificially raising your GH may therefore increase your risks of developing diabetes.

Side note:

He was given intravenous fluids and gradually increasing amounts of insulin over five days, after which he was discharged

I'm hoping decreasing.

 

[Muscle Overkill]

Its all fun and games till you shit your liver ! I reapeat over and over on this board about the excessive doses people take on this board, steroids you can use them or abuse them. I know a MR. Olympia top ten finisher that does not take the kind of doses I see here. I have been out of the seen for 5 years and do to all the UG's and being able to obtain shit so cheap peoples doses have skyrocketed it trips me out. I used to pay 120-150 for 1000mgs of winni now you can get 2500mgs for 80.00 thats why I think people are taking so much shit. I got a little side tracked but people need to realize stroids can be dangerous PERIOD.

 

[CO B-man]

Its all fun and games till you shit your liver ! I reapeat over and over on this board about the excessive doses people take on this board, steroids you can use them or abuse them. I know a MR. Olympia top ten finisher that does not take the kind of doses I see here. I have been out of the seen for 5 years and do to all the UG's and being able to obtain shit so cheap peoples doses have skyrocketed it trips me out. I used to pay 120-150 for 1000mgs of winni now you can get 2500mgs for 80.00 thats why I think people are taking so much shit. I got a little side tracked but people need to realize stroids can be dangerous PERIOD.

I definately can see where the relation between the obvious has been abstracted from HGH causing diabetes. lol!

 

[Magick69]

Its all fun and games till you shit your liver ! I reapeat over and over on this board about the excessive doses people take on this board, steroids you can use them or abuse them. I know a MR. Olympia top ten finisher that does not take the kind of doses I see here. I have been out of the seen for 5 years and do to all the UG's and being able to obtain shit so cheap peoples doses have skyrocketed it trips me out. I used to pay 120-150 for 1000mgs of winni now you can get 2500mgs for 80.00 thats why I think people are taking so much shit. I got a little side tracked but people need to realize stroids can be dangerous PERIOD.

amen!

 

[macrophage69alpha]

gh blunts insulin sensitivity, plain and simple.

GH use can increase the risk of type II diabetes, though simple precautions to maintain insulin sensitivity will generally ameliorate that risk

 

[danymal04]

and what are these simple precautions to maintain insulin sensitvity?

 

[jmead]

bump for that question ^

 

[macrophage69alpha]

and what are these simple precautions to maintain insulin sensitvity?

regular cardio

glucorell

good pottassium to sodium intake ratio (ideally 2 to 1- though even 1-1 is better than most diets)

avoid high fructose corn syrup

avoid trans fats

increase omega 3 fats

watch saturated fat intake (more saturated fat means you need more omega 3's)

 

[52_21_30]

regular cardio

glucorell

good pottassium to sodium intake ratio (ideally 2 to 1- though even 1-1 is better than most diets)

avoid high fructose corn syrup

avoid trans fats

increase omega 3 fats

watch saturated fat intake (more saturated fat means you need more omega 3's)

Macro is dead on as usual. Decreased insulin sensitivity increases your risk for DM type II. Most Americans decrease their insulin sensitivity by eating total garbage diets loaded with preservatives, processed foods, and refined sugar. Combine that with a sedentary lifestyle and you'll be grabbing your left shoulder and clipping off your gangrenous toes in no time. If you're truly committed to the bodybuilding lifestyle (and by that I mean the not so healthy part of AAS/GH use but also the clean dieting and constant training) the favorable things you do should outweigh the unfavorable. However, a very large variable comes into play, and that is your genetics.

Oh and using an insulin sensitizer like Glucorell with your GH is about the best thing you can do.

 

[danymal04]

Word,... Good thing I got most of them things in check in my diet

I dont know what glucorell is though.. sugar inatake?

regular cardio

glucorell

good pottassium to sodium intake ratio (ideally 2 to 1- though even 1-1 is better than most diets)

avoid high fructose corn syrup

avoid trans fats

increase omega 3 fats

watch saturated fat intake (more saturated fat means you need more omega 3's)

 

[macrophage69alpha]

Glucorell R

the discount code is

afdiscount

 

[danymal04]

yeah, I'm sure I get a good amount of that ALA in my greens... I'm pretty good about that. For some reason, nomatter how many supps there are out there, there is always another one.

For people who don't like vegitibles and shit like that with alpha lipoic acid should really consider this supp.

(Food Lipoyllysine) (mg/g dry weight) (Servings) Alpha-lipoic acid*/serving (mcg)#
Beef kidney 2.6 3 ounces (85 g) 32
Beef heart 1.5 3 ounces (85 g) 19
Beef liver 0.9 3 ounces (85 g) 14
Spinach 3.2 1 cup raw (30 g) 5
Broccoli 0.9 1 cup raw (71 g) 4
Tomato 0.6 1 medium (123 g) 3
Peas 0.4 1 cup raw (145 g) 7
Brussel sprouts 0.4 1 cup raw (88 g) 3
Rice bran 0.2 1 cup (118 g) 11
Egg yolk 0.05 1 large (17 g) 0.3

(Food Lipoyllysine)(mg/g dry weight) (Serving) Alpha-lipoic acid*/serving(mcg)#
Beef kidney 2.6 3 ounces (85 g) 32
Beef heart 1.5 3 ounces (85 g) 19
Beef liver 0.9 3 ounces (85 g) 14
Spinach 3.2 1 cup raw (30 g) 5
Broccoli 0.9 1 cup raw (71 g) 4
Tomato 0.6 1 medium (123 g) 3
Peas 0.4 1 cup raw (145 g) 7
Brussel sprouts 0.4 1 cup raw (88 g) 3
Rice bran 0.2 1 cup (118 g) 11
Egg yolk 0.05 1 large (17 g) 0.3

 

[macrophage69alpha]

probably not....
each capsule is 100mg, generally people take 6 per day. that would be 600,000mcg.

basically the amount in 20,000 ounces of beef kidney or 90,000 cups of raw peas.

 

[macrophage69alpha]

^^

 

[bbkingpin]

Can you just counteract that with sugar? Just eating a candy bar or something? Can you buy tests OTC to test your blood sugar levels?

Exactly. That's all you have to do. But if you were in the middle of a competition and experienced that kind of fatigue, it would really impact you. I am talking the kind of low blood sugar that makes you feel like fainting, it is fainting actually.

 

[macrophage69alpha]

Exactly. That's all you have to do. But if you were in the middle of a competition and experienced that kind of fatigue, it would really impact you. I am talking the kind of low blood sugar that makes you feel like fainting, it is fainting actually.

heat exacerbates this feeling as does dehydration.

 

[narshh]

yeah...why would gh do it...fuckin slin would be fucking with your natural amounts of insulin in your body and would cause it no?

Yep

 

[macrophage69alpha]

^^