Hey Smart Guys...Why is Anavar suppressive?

[atutt2]

http://jcem.endojournals.org/cgi/co...jkey=17cfa0e6eacf0320a6cb1c47233c6e08a627fd3d
I'm sure most of you have seen this study which shows that daily admin of 15mg of anavar will cut your natural Total Test production in half in just 5 days. Does anyone know the exact reason/cause?
If we assume that it is a non-aromatizing AAS, and estrogen loop feedback is what causes typical HPTA shutdown, why is var doing this????
Fonz? Dr JMW? Anyone know???

 

[Duncan_floyd]

THANK YOU THANK YOU I have said this all along with no avail. i've been called crazy many times over for stressing this but oh well thanks again.good post

 

[view]

Because your providing your body with external hormones.

 

[NYBodyguard]

when a drug is expensive people find all types of bullshit about it

 

[buckwheat1]

There is a estrogen feedback loop as well as androgen feedback loop. That simple. In a normal male, if estrogen production is inhibited, testosterone levels will increase. But they will only increase so much before androgen suppression kicks in.

 

[b1ewsw32]

http://jcem.endojournals.org/cgi/co...jkey=17cfa0e6eacf0320a6cb1c47233c6e08a627fd3d
I'm sure most of you have seen this study which shows that daily admin of 15mg of anavar will cut your natural Total Test production in half in just 5 days. Does anyone know the exact reason/cause?
If we assume that it is a non-aromatizing AAS, and estrogen loop feedback is what causes typical HPTA shutdown, why is var doing this????
Fonz? Dr JMW? Anyone know???

There's 3 negative feedback loops that effect the HPTA- androgens,estrogens and progestogens.

I've read that oxandrolone has an affinity for the androgen receptor.
Also your study demonstrates that ox induced an increase in AR expression.

Binding to the AR by ox has been shown to be stronger then testosterone and nandrolone.

Therefore negative feedback via the androgen system will be the culprit in HPTA supression.

B32

 

[kbrkbr]

Interesting thread.

 

[Jenetic]

There's 3 negative feedback loops that effect the HPTA- androgens,estrogens and progestogens.

I've read that oxandrolone has an affinity for the androgen receptor.
Also your study demonstrates that ox induced an increase in AR expression.

Binding to the AR by ox has been shown to be stronger then testosterone and nandrolone.

Therefore negative feedback via the androgen system will be the culprit in HPTA supression.

B32

Agreed.

 

[atutt2]

There's 3 negative feedback loops that effect the HPTA- androgens,estrogens and progestogens.

I've read that oxandrolone has an affinity for the androgen receptor.
Also your study demonstrates that ox induced an increase in AR expression.

Binding to the AR by ox has been shown to be stronger then testosterone and nandrolone.

Therefore negative feedback via the androgen system will be the culprit in HPTA supression.

B32

But isn't estrogen the number one mechanism over HPTA vs all others?
Could the drop in test levels be due to increased neuro-net activity?
Some type of neuro-net overload and effect of DHT?

 

[satchboogie]

this isnt some'n new..

ANY steroid will slow down naturaly test levels.