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Can anyone comment on this?
Heart problems from roid use?
- Thread starter Muscle Mafia
- Start date
High amounts of GH can give you some issues with the heart along with other problems. Not sure if AS can be directly linked to any heart problems.
A friend mentioned that large doses of aas could likely damage the heart. I'm not sure what "large doses" are, but he isn't doing large cycles. I thought I read a while back a thread where this was discussed, but I cant find it. If anyone else has info or an opinion, I'd love to hear it.
kbrkbr said:
Sure AAS can by bad for your heart. AAS not taken probably or abused can increase Blood Pressure and Rise your Lipid Profile, this of course can lead to dmg. Now if your asking does AAS contribute to an enlarging of the heart. I'm sure there are people out there that will say yes, but I do not beleive there have been documented cases. Most people that claim AAS dmg'd there heart already had some kind of Heart Problems before they took them, and probably never knew it, or chose to ignore it. Thats my opinion.
Regards
JP@Ironology
New member
kbrkbr said:
I with you on this one bro.
needsize said:
Well that's good news!!
Thanks for all the input bros.
got2getripped
New member
meatneck said:
Loving everything you see!
Yes, its possible.
Androgen Receptors Mediate Hypertrophy in Cardiac Myocytes
James D. Marsh, MD; Michael H. Lehmann, MD; Rebecca H. Ritchie, PhD; Judith K. Gwathmey, VMD, PhD; Glenn E. Green, MD; ; Rick J. Schiebinger, MD
From the Program in Molecular and Cellular Cardiology, Departments of Medicine and Otolaryngology, Harper Hospital, Detroit, Mich; the VA Medical Center, Boston University Medical Center, Boston, Mass (J.K.G.); and the Arrhythmia Center/Sinai Hospital (M.H.L.) and Wayne State University School of Medicine, Detroit, Mich (J.D.M.).
Correspondence to James D. Marsh, MD, Wayne State University School of Medicine, 421 E Canfield Ave, Detroit, MI 48201. E-mail [email protected]
Abstract
Top
Abstract
Introduction
Methods
Results
Discussion
References
Background—The role of androgens in producing cardiac hypertrophy by direct action on cardiac myocytes is uncertain. Accordingly, we tested the hypothesis that cardiac myocytes in adult men and women express an androgen receptor gene and that myocytes respond to androgens by a hypertrophic response.
Methods and Results—We used reverse transcription–polymerase chain reaction methods to demonstrate androgen receptor transcripts in multiple tissues and [3H]phenylalanine incorporation and atrial natriuretic peptide secretion as markers of hypertrophy in cultured rat myocytes. Messenger RNA encoding androgen receptors was detected in myocytes of male and female adult rats, neonatal rat myocytes, rat heart, dog heart, and infant and adult human heart. Both testosterone and dihydrotestosterone produced a robust receptor-specific hypertrophic response in myocytes, determined by indices of protein synthesis and atrial natriuretic peptide secretion.
Conclusions—Androgen receptors are present in cardiac myocytes from multiple species, including normal men and women, in a context that permits androgens to modulate the cardiac phenotype and produce hypertrophy by direct, receptor-specific mechanisms. There are clinical implications for therapeutic or illicit use of androgens in humans.
Androgen Receptors Mediate Hypertrophy in Cardiac Myocytes
James D. Marsh, MD; Michael H. Lehmann, MD; Rebecca H. Ritchie, PhD; Judith K. Gwathmey, VMD, PhD; Glenn E. Green, MD; ; Rick J. Schiebinger, MD
From the Program in Molecular and Cellular Cardiology, Departments of Medicine and Otolaryngology, Harper Hospital, Detroit, Mich; the VA Medical Center, Boston University Medical Center, Boston, Mass (J.K.G.); and the Arrhythmia Center/Sinai Hospital (M.H.L.) and Wayne State University School of Medicine, Detroit, Mich (J.D.M.).
Correspondence to James D. Marsh, MD, Wayne State University School of Medicine, 421 E Canfield Ave, Detroit, MI 48201. E-mail [email protected]
Abstract
Top
Abstract
Introduction
Methods
Results
Discussion
References
Background—The role of androgens in producing cardiac hypertrophy by direct action on cardiac myocytes is uncertain. Accordingly, we tested the hypothesis that cardiac myocytes in adult men and women express an androgen receptor gene and that myocytes respond to androgens by a hypertrophic response.
Methods and Results—We used reverse transcription–polymerase chain reaction methods to demonstrate androgen receptor transcripts in multiple tissues and [3H]phenylalanine incorporation and atrial natriuretic peptide secretion as markers of hypertrophy in cultured rat myocytes. Messenger RNA encoding androgen receptors was detected in myocytes of male and female adult rats, neonatal rat myocytes, rat heart, dog heart, and infant and adult human heart. Both testosterone and dihydrotestosterone produced a robust receptor-specific hypertrophic response in myocytes, determined by indices of protein synthesis and atrial natriuretic peptide secretion.
Conclusions—Androgen receptors are present in cardiac myocytes from multiple species, including normal men and women, in a context that permits androgens to modulate the cardiac phenotype and produce hypertrophy by direct, receptor-specific mechanisms. There are clinical implications for therapeutic or illicit use of androgens in humans.
I am no doctor, but this question keeps coming up and this is what I know. Steroids or not, the left ventricle can enlarge just from BB. This is not uncommon and is called 'hypertrophy' . The heart muscle enlarges like other muscles. So, steroids will potentiate the enlargement. I have not seen studies that show this to be of significant concern. I have this condition and I have not used AAS, just a natural BB. There is also cardiomyopathy, which is the stretching of the ventricle. This is bad as it reduces the elasticity and the pumping ability and may be that this is what the poster is referring to. I have not seen studies that show steroids cause this condition. With all that said, I am sure there is more research out there that can shed light on this. And of course, constant elevated lipids over the long term would not be good for the cardiovascular system. Hope I am not too far off from what is being asked as it has been a long day.
Oh, I guess the other hormone is GH, which has the reputation for potentially enlarging organs. That one I do not have enough knowledge to comment on.
Oh, I guess the other hormone is GH, which has the reputation for potentially enlarging organs. That one I do not have enough knowledge to comment on.
instant.muscle
New member
dont wanna sound like an idiot but can someone giv me a mature response, what is AAS? thx
This was all taken the day after my heart attack. Its all lower now.
Cholesterol 190, Tryglycerides 187, HDL 36, LDL 126
Day of my heart attack I was 6' 1 135lb 13-14% BF. I was running 14 min 2 mile 2x a week. Don’t smoke and my arteries are fine. I have had borderline untreated high blood pressure but nothing alarming. 140/80
My mother is the only one who has has heart problems and she has been a heavy smoker since she was 14.
A blood clot came from who knows where and blocked my main artery causing the Heart attack. They did angeojet to suck out the clot. It just really sucks nobody has any idea where the clot came from. They ran many tests to find out why my blood would clot and everything came up neg.
Here is what the final report said:
Post-procedure angiogram demonstrated a no obstructive plaque in his right coronary artery. Our presumption is that he ruptured a no obstructive plaque in his right coronary artery leading to his acute myocardial infarction. We did entertain the possibility of a prothrombotic state and did perform a hypercoagulable workup. Some is still pending. (That came up neg as well later on)
Cholesterol 190, Tryglycerides 187, HDL 36, LDL 126
Day of my heart attack I was 6' 1 135lb 13-14% BF. I was running 14 min 2 mile 2x a week. Don’t smoke and my arteries are fine. I have had borderline untreated high blood pressure but nothing alarming. 140/80
My mother is the only one who has has heart problems and she has been a heavy smoker since she was 14.
A blood clot came from who knows where and blocked my main artery causing the Heart attack. They did angeojet to suck out the clot. It just really sucks nobody has any idea where the clot came from. They ran many tests to find out why my blood would clot and everything came up neg.
Here is what the final report said:
Post-procedure angiogram demonstrated a no obstructive plaque in his right coronary artery. Our presumption is that he ruptured a no obstructive plaque in his right coronary artery leading to his acute myocardial infarction. We did entertain the possibility of a prothrombotic state and did perform a hypercoagulable workup. Some is still pending. (That came up neg as well later on)
