It was done in 2004. I love these studies but we all know that no matter how many studies are done to show the benefit of these they will always be classified as illegal with hefty fines and jail time. unlike womens HRT which if found in a womans car with or with out a script would not get in trouble, yet it can cause a stroke or a heart attack. Yoiu tell me which is safer>!>!>!>!>!