It's very individual. In my experience..I usually tend to know when my nipples get kinda puffy, then I start noticing that they hurt when I sleep on my stomach , when my shirt brushes against my nipple it hurts and lastly when I feel for lumps I feel a small BB sized lump usually to the left of one nipple. Here's what you should do. STOP playin with them or thinking of them for 4 days. Then gently touch your nipples ( I'm not coming on to you here), and feel around for lumps or pain. The thing is...I never know if the lumps I am feeling were there prior to cycle or if their new. So, get to know your tits BEFORE a cycle...lol. Alright...so, if YOU feel lumps and your nips (any part) are tender or sore . Get some Nolvadex and try taking 10mg on the first day, 20 on the second. If you seem to tolerate the drug (most people do..I just think it's safe to start out slow on any new drug). Bump it up to 40-60mg for a day and then half of that dose on the next day and keep running it at 20mg ED. The symptoms will clear up in about 2 weeks, you'll see an improvement within days, but 2 weeks you should be ok. Are you using test and/or d-bol?