I got a kick ass piece of advice from Night Fly. She, Spatts, and a few others reworked my leg routine several months back.
I hit squats for 5 x 5... then finished leg day with 2 sets on the leg press at 20 reps. The two high reps sets were a killer finish... and I saw my leg size go up 1 1/2 inches in about 12 weeks.