GHB and liver function

[Fukkenshredded]

I posted over anabolicfitness about this. I am amused at the supporting literature used for the manufacturing/distribution of Xyrem, which is GHB (Sodium Oxybate). Interestingly, when ingested GHB increases the reserves of NaDH, which suggests IMPROVED liver function.

Funny how in the Scheduling hearings it was 'toxic to the liver'.

Anyway, among the symptoms treated is included "catalexy, which is the sudden loss of muscle tone associated with narcolepsy"...

Furthermore, in the documentation presented to the FDA and other authoritative bodies contains the studies that show that GHB..."in therapeutic doses can markedly improve muscle tone and function over time..."

Imagine that.

 

[TraxZBT]

interesting... but i don't know what the government is going to do once Xyrem is out and millions of people are going to use it for a while and grow dependent on it. The withdrawls from this stuff is NOT fun.

 

[Delinquent]

^^

 

[Fukkenshredded]

Withdrawals? How can one have withdrawals from a substance that has no metabolites?

 

[therookie]

Withdrawals? How can one have withdrawals from a substance that has no metabolites?

I hope your joking.......I was hospitalized for 4 days during my GHB withdrawel/detox.....It is similar to alchohol withdrawel and you can die from it, due to advance tachacardia...

It was the worst 2 weeks of my life....I was taking it 24/7 for 3 months. The reason you go into withdrawel is actually a Dopamine Rebound. Everytime you take GHB you are surpressing the dopamine in your body, so eventually time after time of use when you stop, its like opening the floodgates....

 

[dumbell150]

Rook - Last summer i was "Utilizing" G for close to 2 months and stopped cold turkey.....I didnt have the slightest form of withdrawl. And i have friends who have not felt withdrawl symptoms either. So please explain

 

[therookie]

Rook - Last summer i was "Utilizing" G for close to 2 months and stopped cold turkey.....I didnt have the slightest form of withdrawl. And i have friends who have not felt withdrawl symptoms either. So please explain

Sure no problem

When you use it once or twice a day its ok because you are giving your brain ample time to release the dopamine.....

When you are dosing every 2-3 hours around the clock you never get to release the dopamine and when you finally stop it is not something to joke with...

If you ever see yourself shortening your time of use....Step back...I got caught up like many people......

Read some posts on this site youll see what i mean...
http://communities.msn.com/GHBaddiction/general.msnw?action=get_threads


Also hers is the medical guidlines to treat the withdrawel just in case you know anyone who ever needs it.

http://216.239.51.100/search?q=cach...h/GHB_Withdrawal.pdf+ghb+addiction++pdf&hl=en


Be safe

 

[Fukkenshredded]

Gotta disagree with you on this one. I, too, stayed on GHB one summer, all day every day, quit cold one day when I saw gyno, and had no withdrawals at all. I must admit, however, that my sleep patterns were altered somewhat, but nothing that was unbearable or intrusive to my life.

I probably took 20-30 grams daily for ten, twelve weeks on end.

Strangely, it seemed to clarify my thinking at times.

I wonder if 'addiction' is an accurate word to describe the condition you were in. Two weeks seems to be an incredibly long time to "need GHB". You seem to be suggesting that the addiciton is to a dopamine rebound, or something along those lines. Again, there is no physiological data to support this rebound creating withdrawal symptoms. I can understand the assertion that such a rebound might result in a mild depressive state, at worst...but withdrawals? Have you ever actually had real withdrawals? Like say, from heroin or crack? Or, if your body chemistry is correct, alcohol? I don't know alcohol, but I do know the big boys and those withdrawals are nothing to compare the slight angst from GHB cessation with. We are talking two very different wordls here.

I wonder why, in over forty years of medical research, addiction was never cited as even a possibility until this drug was made illegal. Weird.

The New England Journal of Medicine has several references to the 'virtual non-toxicity and lack of potential for addiction' of this food.

Weird.

The very definition of addiction, in medical terms, requires the presence of metabolites from the addictive substance, yet GHB has none.

Weird.


I will agree that this drug/food has to be treated with a great deal of respect, because it DOES have a nasty bite. THAT much I will agree with. I will also agree that it is not for everyone, because the response curve is much sharper than with most drugs. But actual addiction to this? That's a stretch. But hey, it might be possible that people's bodies react differently on a very subtle level. What might be habit forming to me could very well be addictive to you, or vice verca. In the end, it is not my wish to convert people to GHB use. In fact, I would recommend to most that it is an unecessary risk in their lives. It is a substance that, as I said, requires attention with use. Anyway, just my input, ya know?

 

[Fe3]

I have to agree with fuckin shredded.
I was using 6-7 times a day for a year, or more and no withdrawls, but, mentally you can, with in turn can probably lead to physical symptoms.

 

[therookie]

Hey im not gonna argue with you here but i can say 2 things, you were eaith using less than lab grade G and you are lucky.............

Like i said, read the above links i posted.....I have a freind who died during detox because he was not under medical care. Like i said your lucky i guess and also, i did it for about a year every day...Until it came down to doing it 24/7 around the clock...waking up every two hours taking more to sleep and so on...Sooner or later it catches up with you.......It is the hardest and scariest thing i have ever gone through.........

Just be careful thats all........

Peace out

 

[Suspension]

No withdrawls from GHB? Hey, I didnt either. We are both lucky. I know MANY, MANY people who have gone through terrible withdrawls. One of these persons is a close friend. Ive talk to him in detail about it. He was hooked--bad. Anyone who says that you cannot become dependent on GHB is ignorant.

 

[Suspension]

Whats also funny is these Internet sites claiming "no withdrawel symptoms whatsoever" or, "one cannot become dependent"

For my friend, it started once a day. He liked the feeling. Then progressed to twice a day, then every fucking time he came down from the stuff. He tried to go off completely, and he had terrible withdrawel. Please, everyone, dont belive all this BS about its not addicting--youll only get yourself in trouble.

 

[juggernaut7]

be safe

know your substance
know your source
know your self
be safe

 

[Fukkenshredded]

I think there are two points that were made that pertain here. First, the issue of lab grade GHB and purity levels. Here's my theory:

Not everyone who thinks they are taking GHB is ACTUALLY taking GHB. They might be taking one of the precursors or postcursors, and many of those DO have resulting metabolites that could potentially create an addiction.

Case in point:
1,4 butanediol is often times anectdotally cited as being 'more addictive' than GHB itself. I, personally, have found that there is a certain 'pull' toward 1,4 that creeps up with continued usage. It isquite possible that in the absence of pharmaceutical grade GHB a dealer might substitute this, or any of several, precursors or postcursors (1,4 is a postcursor) and thereby contribute to the idea that GHB itself is physically addicting.

Another point was made, and that is to know yourself. Every story that I hear about GHB addiction involves long, repeated uses. This is where I get confused. To me, if you do something that you are not yet addicted to again and again, you are forming a habit. I wonder when the habit transforms into an addiction. I mean, if you feel yourself jonesing for a cap, then its time to back off, see? No big deal. And therein lies the difference between addiciton and habits. With crack, it takes one toke, folks. ONE TIME. And the addiction is VERY REAL. The brain plays every trick in the book. Same goes for heroin. I know what I am talking about, because I went through both. Crack is almost unbeatable. Its there, every day, even years later. Like a monster, asleep under a rock. THAT is addiction.

So...I can maybe agree that if one ABUSES GHB or a precursor that a certain limited depency can result, but there is so much time to see this coming up that it is difficult for me to comprehend anyone finding themselves 'suddenly addicted.' It just seems more like people not paying attention and getting foolish.

I have noticed a correlation between intelligence level and claims of GHB addiction, and I think this correlation is obvious. Furthermore, there seems to be a correlation between AGE and this so called addiction, again, an obvious one. Is it coincidence that the people who claim addiciton to this drug were both young and at an early stage in their drug use experiences? It makes me wonder if they are qualified to asses their own condition.

With the oxycontin uproar, the FDA would be reluctant to pass any new drug, orphan or not, that had the 'addictive potential of heroin' that has been claimed by the ignorant. In my opinion, GHB would be no more addicting than any sleep aid. After all, there are people who SWEAR that they are addicted to tylenol pm.

 

[Fukkenshredded]

One more thing here...

Rookie, you say you had a friend that DIED from GHB detox?

I am afraid that this is highly, highly unlikely if not impossible. I have searched and searched the medical references on this substance and not ever have I seen onhe claim of anyone dying from a detox. What is there to detox from? GHB metabolizes into WATER, bro. How do you detox from something that is NOT TOXIC?

May I suggest that your friend had an entirely different drug problem, and that GHB was not the primary factor in his death.

Because here's the deal. I write for several movements, including Alchemind from time to time. Moreover, I write my senator and other legislative bodies about this very issue, as well as others that involve massive hysteria. I would be very interested in the details of this medical anomaly. Because you realize that your friend is the ONLY PERSON TO HAVE EVER DIED FROM GHB DETOX.

And this reference you made to your own detox. Again, what was the hospital removing from your blood? Dopamine is not toxic, is it? Are you SURE that it was GHB you were taking, and not an analogue? I mean, ABSOLUTLEY CERTAIN? If you say you are certain, then you can tell me what is required to reduce monsodium glutamate into GHB (sodium oxyslate), and you can tell me the difference between that reduction and the reduction of 1,4 butanediol (which is probably what you had), because a metabolite of 1,4 is ethylene glycol, and that IS poisonous, now isn't it?

So bring me up to speed, here...tell me what I have overlooked about this. I want to know.

 

[sirperry1]

I was using it every night for about six months....things started to get weird...Did I go through withdrawls ...Fuck ya!!!! Be careful with G, GBL, 1,4 .

 

[Amp]

I was taking it 24/7 for 3 months.

That 3 months must have been fun.

That's like staying drunk for 3 months straight without the calories or hangovers.

 

[Fukkenshredded]

Uh, rookie...? An answer would be appreciated here.

 

[therookie]

He had a heart attack.....

 

[therookie]

1,4 Butandiol id the worst when it comes to withdrawels......I wish i can still do the drug, its the best drug int the world.

 

[Fukkenshredded]

I see.