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HammerNail
New member
I have been reading some articles that state that IGF1 is more anabolic than GH. Any body have any experience with IGF1?
GH vs IGF1
- Thread starter HammerNail
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IGF-1(and 2,3,4,5 etc) work in a complex symetry with hGH and insulin. Basically, you need all 3 together to get the right results.
IGF-1 is unique in that it causes localized skelatal muscle growth in the tissue adjacent to it's receptors. (exoGH does not cause muscle growth on it's own).
"Real" lab grade IGF is hard to handle and hard to come by.
IGF-1 is unique in that it causes localized skelatal muscle growth in the tissue adjacent to it's receptors. (exoGH does not cause muscle growth on it's own).
"Real" lab grade IGF is hard to handle and hard to come by.
nautica
New member
Ironmaster - I have a question.
almost everything I have seen talks about using these 3 substances together.
But lately, since IGF-1 R3 long has come into play - the word is not to use slin with it - b/c of the increased potential of going hypo. And that the only reason slin was used was to increase the half-life of the IGF-1, which has been taken care of by the R3 Long Chain.
What are your thoughts???
Thanks
Nautica
almost everything I have seen talks about using these 3 substances together.
But lately, since IGF-1 R3 long has come into play - the word is not to use slin with it - b/c of the increased potential of going hypo. And that the only reason slin was used was to increase the half-life of the IGF-1, which has been taken care of by the R3 Long Chain.
What are your thoughts???
Thanks
Nautica
HGH does two things. First, it has a localized effect on adipose cells; it causes lipolysis. Second, it stimulates the release of IGF-1 from peripheral tissues. IGF-1 is then bound by IGFBP (the most dominant being IGFBP-3) and transported to the tissues to stimulate growth (hyperplasia-not hypertrophy like AAS).
As we age, our bodies become resistent to our own hormones--especially insulin, HGH, Growth Hormone Releasing Hormone, LH, FSH, etc. We have overcome the HPTA resistence/lack of function by supplementing with Testosterone and other AAS. There does not seem to be much resistence to Testos. at any age--the side effects are the problem. HGH resistence is a problem. And even Dr. Ronald Klatz, the father of rHGH therapy, has suggested that IGF-1 supplementation is the future as far as HGH is concerned. Long R3 IGF-1 sidesteps the problems of IGF-1's short half-life and it sidesteps the HGH resistance problem. It even side steps the genetic/envornmental problem of a lack of IGFBP-3. You need lots of IGFBP-3 to keep IGF-1 active longer. Not surprisingly, top athletes have LOW free IGF-1 levels and high IGFBP-3 levels. Long R3 IGF-1 works longer regardless of the IGFBP-3 levels. More research needs to be done on IGF-1 and its role in metabolism, weight control, aging, etc.
As far as availability, it is widely available to researchers/doctors. Assuming using 50mcg EOD and every other month (because of upregulation), the costs aren't as bad as originally thought. Each month will cost about $1900.00. Obviously, everyone needs to deicdie if this investment is affordable or if it is too rich.
As we age, our bodies become resistent to our own hormones--especially insulin, HGH, Growth Hormone Releasing Hormone, LH, FSH, etc. We have overcome the HPTA resistence/lack of function by supplementing with Testosterone and other AAS. There does not seem to be much resistence to Testos. at any age--the side effects are the problem. HGH resistence is a problem. And even Dr. Ronald Klatz, the father of rHGH therapy, has suggested that IGF-1 supplementation is the future as far as HGH is concerned. Long R3 IGF-1 sidesteps the problems of IGF-1's short half-life and it sidesteps the HGH resistance problem. It even side steps the genetic/envornmental problem of a lack of IGFBP-3. You need lots of IGFBP-3 to keep IGF-1 active longer. Not surprisingly, top athletes have LOW free IGF-1 levels and high IGFBP-3 levels. Long R3 IGF-1 works longer regardless of the IGFBP-3 levels. More research needs to be done on IGF-1 and its role in metabolism, weight control, aging, etc.
As far as availability, it is widely available to researchers/doctors. Assuming using 50mcg EOD and every other month (because of upregulation), the costs aren't as bad as originally thought. Each month will cost about $1900.00. Obviously, everyone needs to deicdie if this investment is affordable or if it is too rich.
nautica
New member
So what about the use of HGH and slin along with IGF-1 R3 Long - is that a thing of the past with the new R3Long or is it still something that needs to be taken together.
If so, How would one incorporate the 3.
What time of day should each be taken and what would the doses be???
Thanks
nautica
If so, How would one incorporate the 3.
What time of day should each be taken and what would the doses be???
Thanks
nautica
HammerNail
New member
DrJMW said:
Very interesting. So HGH in it self does not produce significant levels of IGF1 I assume. According to the article I read it stated that IGF1 will cause organ enlargement that is irreversible. This can lead to stomach distention, and organ failure. So the sides are pretty negative I would think. Are body builders using iGF1 with HGH or are they using HGH by itself in hopes that it will convert to IGF1 in the liver?
ExoGh does increase IGF-1. Yes, IGF-1 causes local tissue growth, but primarily skelatal muscle growth which is a good thing.
I also read an abstract recently that indicated that certain orals.....primarily anavar........significantly increased IGF-1. And I always thought anavar was largely useless.
As for the the long R3 IGF-1........the stuff that purports to be, anyway.......that is/was available and cheap on the web.......why do I not hear anyone raving on their results here? Hmmmm.
I also read an abstract recently that indicated that certain orals.....primarily anavar........significantly increased IGF-1. And I always thought anavar was largely useless.
As for the the long R3 IGF-1........the stuff that purports to be, anyway.......that is/was available and cheap on the web.......why do I not hear anyone raving on their results here? Hmmmm.
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