Since starting depot-provera three months ago a friend of mine has noticed large weight gain. She has expressed an interest in exercising to get in shape. Have any of the board members had experience with a fat loss regiment while taking this? Does anyone know how it interacts with other supplements be they hormonal or otherwise? Thanks for any input.

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It has been known to jack up your hormonal balance so bad...and for extended periods of time as well (in my case, I spotted for over a year off & on...mostly on). Yeah, it's birth control all right...but not worth it if you create havoc on your body...IMO.