Bro, I have had a great deal of luck doing the following. 5 pellets crushed with a pill crusher, using DMSO gel ( about a quarter size lump ). Mix in a small bowl and nuke for 8 seconds, take out and mix with finger. Of course I have already washed my hands with an anti-bacterial soap. Apply isopropyl alcohol ( rubbing ) to the application sites to sterilize. Rub the mixture into the sites, it takes about 5 minutes. Make sure nothing touches these areas ( clothing with dye, your dog, road kill etc. ) for about 2 hours. Then apply an aloe vera gel mixture to the site areas to keep the skin healthy. I do this in the evening after I have lifted, and when I will be on the computer for about 2 hours. I shower in the morning as usual. I think people get into the realm of skin irritation when they plastic wrap the area overnite. This does not increase the absorbtion ( as most is probably absorbed in the first 30 minutes) and does not allow the skin to breathe.