Fonz said:
First off, taking one case and extrapolating that DNP causes hepatic and cardiac damage is ludicrous. You would get laughed out of Med school for that claim. Also, you have NO IDEA of the womans medical history..none whatsoever. And the fact its from 1934 doesn't do wonders for its medical credibility either.
Anyways, all her symptoms are CONSISTENT with dehydration(weakness and diziness are a prime example) caused by the DNP which then caused milld HYPERTHERMIA(101.8F = 38.8C) 38.8C is nowhere close to what you see in hyperthermic DNP patients......hyperthermia caused by DNP is in the 40.0C+ range(Thats 104F)...and when the core temperature reaches 41.0C(105.8F) is when you start to cook yourself from the inside out, and brain damage, cardiac damage, pretty much every single organ suffers damage....and you eventually die.
AT 38.8C(101.8F), there is no way she would be in a HYPERTHERMIC state. She would be sweating quite a bit, thats it.(In case anybody is wondering normal human body temps oscillate between 36.5C and 37.5C(97.8F and 99.5F)
Sorry, but I don't buy it.
Fonz
fonz im not mamking a personal attack but your assessment of the situation is tunnel visioned and simplistic. you neglect to consider that the human organism is a complex system and is susceptable to damage from more causes than just overheating.
the fact of the matter is that this woman took DNP and died.
before death she complained of many symptoms associated with DNP toxicity
an autopsy on the woman showed a number of physiological abnormalities.
a logical practitioner should immediately question the association between these abnormalities and the incident DNP use and probable toxicity, especially since many of the abnormalities are consistent with DNPs mechanism of action
I am not saying that DNP was guaranteed, 100% the primary, root cause of this womans hepatic and cardiac damage.
however given the circumstances, one must acknowledge a possible association between the two. hence my statement, DNP is
associated with hepatic and cardiac damage.
now in your above statement you state hyperthermia as a cause of organ disintegration. as such you qualify that DNP can cause this disintegration (whether or not you personally understand that the organ failure may not be caused by heat alone, and may in fact have other toxicological causality)
why is it so hard to believe that the DNP itself was a major factor in this womans death and the occurrance of at least secondary hepatic and cardiac damage?
you state that this woman only had about a 38 degree temperature, which cannot be considered as excessively hot. certainly not hot enough to cause organ failure. yet this womans organs failed. doesnt it make sense, therefore, that something else caused this organ failure? then when you consider taht DNP itself is probably associated with the death, then logically, there must be:
something else, directly associated with DNP administration, which by a means other than hyperthermia, caused massive organ failure
can you see that there is a very big hole in your theory that hyperthermia or allergy is the mechanism by which DNP
may cause death?
furthermore, about your idea that the womans symptoms are probably due to dehydration- do you know what causes dizziness and nausea? virtually everything.
you have a woman who, only hours before her death, complained of dizziness and nausea, who had:
hyperemic and hemorrhagic lungs, degeneration of renal tubules and liver cells, segmentation and fragmentation of cardiac muscles... on autopsy, and your solution is that the woman was
dehydrated???
if i presented this evidence in med school, i wouldnt be laughed at, i would get a lot of shoulder shrugging, a lot of "hmmmmmm"s, and a lot of sentiments that more info would be needed for definitive association- from a lot of people who see the human body with the same sort of grounding that i have
cheers
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