aspartame in large doses is a neurotoxin, aspartame should not be consumed by children or pregnant folk, i wouldn't use it anyway simply for that reason
Long-Term Damage
----------------
It appears to cause slow, silent damage in those unfortunate enough
to not have immediate reactions and a reason to avoid it. It may take
one year, five years, 10 years, or 40 years, but it seems to cause
some reversible and some irreversible changes in health over long-term
use.
Brain Cancer
------------
Aspartame caused large brain tumors in life-long animal experiments
at a dose that could be considered within the "Acceptable Daily
Intake" limit after adjusting for differences in metabolism of
aspartame's breakdown products between humans and rodents.
Not long after the FDA Commissioner went to work as a consultant
for the PR firm of the aspartame manufacturer, FDA Investigator
and Toxicologist, Dr. Adrian Gross stated the following:
In view of all these indications that the cancer-
causing potential of aspartame is a matter that
had been established way beyond any reasonable
doubt, one can ask: What is the reason for the
apparent refusal by the FDA to invoke for this
food additive the so-called Delaney Amendment to
the Food, Drug, and Cosmetic Act? Is it not clear
beyond any shadow of a doubt that aspartame had
caused brain tumors or brain cancer in animals,
and is this not sufficient to satisfy the
provisions of that particular section of the law?
Given that this is so (and I cannot see any kind
of tenable argument opposing the view that
aspartame causes cancer) how would the FDA justify
its position that it views a certain amount of
aspartame (50 mg/mg body-weight) as constituting
an ADI (Allowable Daily Intake) or "safe" level of
it? Is that position in effect not equivalent to
setting a "tolerance" for this food additive and
thus a violation of that law? And if the FDA
itself elects to violate the law, who is left to
protect the health of the public?
Uterine Polyps
--------------
Pre-approval experiments showed that an aspartame breakdown product
caused uterine polyps in experimental animals.
Not long after the FDA Commissioner went to work as a consultant for
the PR firm of the aspartame manufacturer, FDA Investigator, Dr.
Jacqueline Verrett stated the following:
"This (DKP) is the famous study with the uterine
polyps, and it is also the study in which there
were changes in serum cholesterol, significant
changes over the dose range.
"Now, we still are not sure exactly how much of
DKP each group of animals or any individual animal
got; they may not have gotten what would be
calculated on the basis of daily consumption had
the diet been homogeneous.
"The fact is, in spite of that, there were
significant increases--and I think everybody
agrees with that--of uterine polyps and also
changes in blood cholesterol.
"When that was then taken into consideration, they
said, oh, well, obviously, they must have gotten
the diet, because we have these changes. But then
they disregarded the changes as being significant-
-you know, uterine polyps were not pre-
carcinogenic. Well, I can rustle up 15 million
women by this afternoon who will disagree with
that."
Other Hazards
-------------
The following is a selection of other hazards from long-term use of
aspartame. Once these effects are seen clinically, the internal
damage has often been done. Removing aspartame from the diet may
clear up some of the symptoms but the damage from the breakdown
products such as methanol may be permanent.
Seizures and convulsions, arthritic and joint pain, chronic fatigue,
depression, memory loss, vision damage and loss, tingling in the
extremities, slurring of speech, irritability, severe anxiety
attacks, menstrual problems, blood sugar control problems, symptoms
similar to multiple sclerosis, worsening of fibromyalgia, parkinson's
tremors, etc., etc.