2x a week will work fine, but when I use it (or long esters) how/when I take it depends on what else is in the cycle and what dose of each im taking. For example if im running lets say 600 test enth and 600eq per week, I will shoot 1cc eq on monday, then 1cc test on tues and repeat. Keeps depots small and blood levels constant. Thats just what I do, its not essential.