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Drinking? Protein synthesis?
- Thread starter tommboy
- Start date
wayneboard1
New member
tommboy said:
Nishnish wrote this on another thread and I liked it so here it is.
Re: Alcohol during a cycle
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the bottom line is, whether or not you happen to be using at the time, alcohol use is counterproductive to anabolism in general. there have been countless studies that demonstrate the negative effects of alcohol on the body with regards to maintaining an anabolic environment...
the whole idea when using is to maximize the benefits of the compound taken while minimizing the potential risks. this applies to diet, training, rest, and the avoidance of recreational drugs in general (i include alcohol here).
you must understand that while taking orals your liver will already be working pretty hard, and drinking ma increase your chance of elevating liver values past a healthy point.
this is the difficult choice that the athlete must make- either use and avoid alcohol/drugs OR lessen the effectiveness of your cycle and increase the risk of damage to your body.
i for one refuse to let good drugs that i pay good money for go to waste.
do i get bored sometimes? YES
do i wish i could go out and get shitfaced and chase pussy? YES
but, you can be goddamn sure if i'm going to take the risk of self administering anabolics i'm going to get the most out of it; and if that means sacrificing my social life here and there then so be it. i'll go out when i'm clean.
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Now he was speaking more so of orals but gear in general and alcohol DO NOT MIX SO JUST DON'T DO IT. Practice some self control and eliminate alcohol at least while you are on. As far as protein synthesis, I am searching for that specific answer and will hopefully post it up today sometime.
wayneboard1
New member
Here are a few more cut and pastes I found when using the search button.
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Alcohol use affects all three parts of the hypothalamic-pituitary-gonadal (HPG) axis, a system of endocrine glands and hormones involved in male reproduction. Alcohol use is associated with low testosterone and altered levels of additional reproductive hormones. Researchers are investigating several potential mechanisms for alcohol's damage. These mechanisms are related to alcohol metabolism, alcohol-related cell damage, and other hormonal reactions associated with alcohol consumption.
Research with animals has consistently demonstrated an association between both acute (i.e., one time, one occasion) and chronic (i.e., long-term) alcohol consumption and low testosterone. As testosterone levels decrease, levels of LH and FSH would be expected to increase to stimulate the production of more testosterone. However, studies with young (i.e., pubertal) male rats indicate that both acute and chronic alcohol exposure result in profound testosterone suppression accompanied by lower or normal LH and FSH levels, when elevated levels are expected.
And 1 more;
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Also keep in mind that even though you don't workout on saturday or sunday but if your working out friday your body is not going to be getting the supplements it needs for recovery from that day as well as thursdays workout.
- Alcohol dehydrates causing the water in your body to be used in your liver to help metabolize the alcohol when it should be used elsewhere.
- Alcohol decreases protein absorption into the body therefore hindering your recovery and your gains.
- It is also said that it takes your body 3 days to a week to fully recover from a night of drinking.
- Lest thee not forget all the extra calories of alcohol too.
Other effects that wouldn't hinder you to much since you would not be going to the gym is strength, focus, motivation, intensity and endurance.
And yet another from Ulter who knows his stuff;
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Science? Here's an explanation. For you lazy phucks... It says alcohol impairs protein synthesis.
ONE OF THE METABOLIC hallmarks of chronic alcohol abuse is the negative nitrogen balance resulting from a net catabolism of skeletal muscle proteins (34). An imbalance in protein metabolism, when prolonged, leads to the erosion of lean body mass (LBM) and the proximal myopathy commonly observed in alcoholics (29, 42). It has been estimated that 40-60% of all alcoholics exhibit skeletal muscle disease (42). The maintenance of muscle protein stores is essential because decreases in LBM are causally linked to increases in morbidity and mortality (22). Although alcohol affects all muscle groups to some extent, the fast-twitch type II fibers appear to be particularly vulnerable (29, 42). Available evidence suggests that malnutrition per se does not cause the myopathy, but deficiencies in the nutritional status may exacerbate the disease (4).
Chronic ethanol consumption increases whole body rates of leucine turnover and oxidation in fed rats (3), suggesting the presence of a reduced rate of protein synthesis and/or an increased rate of protein degradation. However, whole body measurements represent the sum of many vastly different organ systems (e.g., muscle and nonmuscle protein synthesis and hepatic secretory protein synthesis) and provide little information concerning individual processes or tissues. However, when the in vivo rate of protein synthesis was measured with the flooding-dose technique (8), acute alcohol intoxication, produced by the intraperitoneal injection of ethanol, markedly decreased the rate of protein synthesis in skeletal muscle, heart, intestine, bone, and skin (34). Moreover, chronic alcohol feeding of rats has also been demonstrated to reduce protein synthesis in skeletal muscle (33).
Although the alcohol-induced decrease in muscle protein synthesis has been recognized for a number of years, the mechanism for the impairment has been largely unexplored. In this regard, Preedy and Peters (33) demonstrated that chronic alcohol consumption produces relatively rapid and large decreases in the amount of total RNA in skeletal muscle. Because the large majority (>80%) of total muscle RNA is ribosomal, these data suggest that at least part of the alcohol-induced impairment in protein synthesis occurs secondary to a reduced number of ribosomes. However, the decrement in protein synthesis in this early study was greater than the decrease in RNA, indicating an impairment in translational efficiency as well. Translational efficiency reflects how well the existing protein synthetic machinery is functioning. Translation of mRNA involves a complex series of reactions, which can be categorized into three phases: initiation, elongation, and termination (5). There are no data pertaining to alcohol-induced alterations on various steps in the pathway of translation. Translational efficiency can be regulated by alterations in either peptide-chain initiation, elongation, or both. Because other catabolic conditions have previously been determined to impair translation initiation, the purpose of the present study was to determine whether chronic alcohol consumption in rats alters specific steps in the initiation process.
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Here is the link to the entire thread I found these posts in when using the search option.
http://www.elitefitness.com/forum/showthread.php?t=427375&highlight=alcohol+protein+synthesis
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Alcohol use affects all three parts of the hypothalamic-pituitary-gonadal (HPG) axis, a system of endocrine glands and hormones involved in male reproduction. Alcohol use is associated with low testosterone and altered levels of additional reproductive hormones. Researchers are investigating several potential mechanisms for alcohol's damage. These mechanisms are related to alcohol metabolism, alcohol-related cell damage, and other hormonal reactions associated with alcohol consumption.
Research with animals has consistently demonstrated an association between both acute (i.e., one time, one occasion) and chronic (i.e., long-term) alcohol consumption and low testosterone. As testosterone levels decrease, levels of LH and FSH would be expected to increase to stimulate the production of more testosterone. However, studies with young (i.e., pubertal) male rats indicate that both acute and chronic alcohol exposure result in profound testosterone suppression accompanied by lower or normal LH and FSH levels, when elevated levels are expected.
And 1 more;
--------------------------------------------------------------------------------
Also keep in mind that even though you don't workout on saturday or sunday but if your working out friday your body is not going to be getting the supplements it needs for recovery from that day as well as thursdays workout.
- Alcohol dehydrates causing the water in your body to be used in your liver to help metabolize the alcohol when it should be used elsewhere.
- Alcohol decreases protein absorption into the body therefore hindering your recovery and your gains.
- It is also said that it takes your body 3 days to a week to fully recover from a night of drinking.
- Lest thee not forget all the extra calories of alcohol too.
Other effects that wouldn't hinder you to much since you would not be going to the gym is strength, focus, motivation, intensity and endurance.
And yet another from Ulter who knows his stuff;
--------------------------------------------------------------------------------
Science? Here's an explanation. For you lazy phucks... It says alcohol impairs protein synthesis.
ONE OF THE METABOLIC hallmarks of chronic alcohol abuse is the negative nitrogen balance resulting from a net catabolism of skeletal muscle proteins (34). An imbalance in protein metabolism, when prolonged, leads to the erosion of lean body mass (LBM) and the proximal myopathy commonly observed in alcoholics (29, 42). It has been estimated that 40-60% of all alcoholics exhibit skeletal muscle disease (42). The maintenance of muscle protein stores is essential because decreases in LBM are causally linked to increases in morbidity and mortality (22). Although alcohol affects all muscle groups to some extent, the fast-twitch type II fibers appear to be particularly vulnerable (29, 42). Available evidence suggests that malnutrition per se does not cause the myopathy, but deficiencies in the nutritional status may exacerbate the disease (4).
Chronic ethanol consumption increases whole body rates of leucine turnover and oxidation in fed rats (3), suggesting the presence of a reduced rate of protein synthesis and/or an increased rate of protein degradation. However, whole body measurements represent the sum of many vastly different organ systems (e.g., muscle and nonmuscle protein synthesis and hepatic secretory protein synthesis) and provide little information concerning individual processes or tissues. However, when the in vivo rate of protein synthesis was measured with the flooding-dose technique (8), acute alcohol intoxication, produced by the intraperitoneal injection of ethanol, markedly decreased the rate of protein synthesis in skeletal muscle, heart, intestine, bone, and skin (34). Moreover, chronic alcohol feeding of rats has also been demonstrated to reduce protein synthesis in skeletal muscle (33).
Although the alcohol-induced decrease in muscle protein synthesis has been recognized for a number of years, the mechanism for the impairment has been largely unexplored. In this regard, Preedy and Peters (33) demonstrated that chronic alcohol consumption produces relatively rapid and large decreases in the amount of total RNA in skeletal muscle. Because the large majority (>80%) of total muscle RNA is ribosomal, these data suggest that at least part of the alcohol-induced impairment in protein synthesis occurs secondary to a reduced number of ribosomes. However, the decrement in protein synthesis in this early study was greater than the decrease in RNA, indicating an impairment in translational efficiency as well. Translational efficiency reflects how well the existing protein synthetic machinery is functioning. Translation of mRNA involves a complex series of reactions, which can be categorized into three phases: initiation, elongation, and termination (5). There are no data pertaining to alcohol-induced alterations on various steps in the pathway of translation. Translational efficiency can be regulated by alterations in either peptide-chain initiation, elongation, or both. Because other catabolic conditions have previously been determined to impair translation initiation, the purpose of the present study was to determine whether chronic alcohol consumption in rats alters specific steps in the initiation process.
__________________
Here is the link to the entire thread I found these posts in when using the search option.
http://www.elitefitness.com/forum/showthread.php?t=427375&highlight=alcohol+protein+synthesis
zips92
New member
tommyboy, a lot of great studies, facts, info posted by wayneboard on the subject. Just something I cannot understand, makes no sense to me:
How can a bro be disciplined enough to consume several meals a day with massive calories and protein, train with indescribable intensity, disinfect, aspirate, follow a strict pct protocol, take all necessary ancillaries, get bloodwork, keep a training and cycle log, do regular cardio, but not be disciplined enough to refrain from drinking?
I agree with you, that I am sure there are juiced bros that do, I just don't understand it (not critical, just truly don't understand). I hope it's less than we think. Maybe the info wayneboard posted will make you think...hopefully about not drinking while using gear!!!!
How can a bro be disciplined enough to consume several meals a day with massive calories and protein, train with indescribable intensity, disinfect, aspirate, follow a strict pct protocol, take all necessary ancillaries, get bloodwork, keep a training and cycle log, do regular cardio, but not be disciplined enough to refrain from drinking?
I agree with you, that I am sure there are juiced bros that do, I just don't understand it (not critical, just truly don't understand). I hope it's less than we think. Maybe the info wayneboard posted will make you think...hopefully about not drinking while using gear!!!!
A
ALIN
Guest
tommboy said:
if your on cycle of AAS i would not drink at all.
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