Does the effect of AS decrease over extended continued use?

[adam]

Does your body develop some sort of tolerance of resistance to growth after being on anabolic steroids over an extended period of time? i.e. would your receptors no longer respond to the drug and therefore diminish growth potential?
Is there a difference if it was mostly anabolic, e.g. Deca or Win. or if the cycle also included higher androgenic properties e.g. d-bol, test?

 

[serge]

your gains slow down as your cycle progresses. for me personally gains come to a full stop by the end of week 8. after that a gear-free break is needed. also as you do more and more number of cycles you will have to raise the dose from one to another.

 

[ironmaster]

It's not so much a matter of resistance or tolerance. Just like we hit a genetic plateau in training naturally, eventually the same thing happens with gear. You will continue to improve in muscle density, maturity, definition, and body composition, but the days of 25 pound gains per cycle will stop.
Taking a more hardcore approach through the use of GH, insulin, EPO etc. will break that steroid plateau temporarily, but after 30 years, I measure gains in a few pounds per year. Your appearance will always improve, though - you just need to look more to the mirror than to the scales.