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Does R-ALA Effect The Cori Cycle?
Does R-ALA effect the Cori cycle? And if so, how so?
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http://www.google.com.au/search?q=c...lycogen+stores+days+"how+much"&hl=en&ie=UTF-8
Lactate is produced during exercise by type 2B muscle fibers during intense exercise. It is almost all recycled into glucose by the liver, and the overall process is known as the Cori cycle.
Type 2B muscle fibers are only recruited during very strenuous exercise, when blood lactate concentrations may rise sharply. Under these conditions some of the surplus lactate may be oxidised by highly aerobic tissues, such as heart muscle.
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http://www.indstate.edu/thcme/mwking/gluconeogenesis.html
Substrates for Gluconeogenesis
Lactate:
Lactate is a predominate source of carbon atoms for glucose synthesis by gluconeogenesis. During anaerobic glycolysis in skeletal muscle, pyruvate is reduced to lactate by lactate dehydrogenase (LDH). This reaction serves two critical functions during anaerobic glycolysis. First, in the direction of lactate formation the LDH reaction requires NADH and yields NAD+ which is then available for use by the glyceraldehyde-3-phosphate dehydrogenase reaction of glycolysis. These two reaction are, therefore, intimately coupled during anaerobic glycolysis. Secondly, the lactate produced by the LDH reaction is released to the blood stream and transported to the liver where it is converted to glucose. The glucose is then returned to the blood for use by muscle as an energy source and to replenish glycogen stores. This cycle is termed the Cori cycle.
Does R-ALA effect the Cori cycle? And if so, how so?
====================
http://www.google.com.au/search?q=c...lycogen+stores+days+"how+much"&hl=en&ie=UTF-8
Lactate is produced during exercise by type 2B muscle fibers during intense exercise. It is almost all recycled into glucose by the liver, and the overall process is known as the Cori cycle.
Type 2B muscle fibers are only recruited during very strenuous exercise, when blood lactate concentrations may rise sharply. Under these conditions some of the surplus lactate may be oxidised by highly aerobic tissues, such as heart muscle.
=======================
http://www.indstate.edu/thcme/mwking/gluconeogenesis.html
Substrates for Gluconeogenesis
Lactate:
Lactate is a predominate source of carbon atoms for glucose synthesis by gluconeogenesis. During anaerobic glycolysis in skeletal muscle, pyruvate is reduced to lactate by lactate dehydrogenase (LDH). This reaction serves two critical functions during anaerobic glycolysis. First, in the direction of lactate formation the LDH reaction requires NADH and yields NAD+ which is then available for use by the glyceraldehyde-3-phosphate dehydrogenase reaction of glycolysis. These two reaction are, therefore, intimately coupled during anaerobic glycolysis. Secondly, the lactate produced by the LDH reaction is released to the blood stream and transported to the liver where it is converted to glucose. The glucose is then returned to the blood for use by muscle as an energy source and to replenish glycogen stores. This cycle is termed the Cori cycle.
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