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Does DNP habituate...?

S

SofaGeorge

New member
Does DNP habituate? After 10-12 weeks ephedrine habituates and loses its effectiveness. Heroin habituates... requiring larger and larger doses. Clen seems to habituate in less than 2 weeks.

So... does DNP habituate? Is there a number of days, weeks, months that it remains strong then starts to lose effectiveness?

Does anyone know?
 
Well.... thyroid levels will decrease.... Which is essentially a feedback loop.
 
My guess would be YES, eventual attenuation would take place.
Although the obvious point is, by that time you'll need a toxicologist to run blood and urine samples on you from that point on..........:D

Why you ask Sofa?
 
drveejay11 said:
My guess would be YES, eventual attenuation would take place.
Although the obvious point is, by that time you'll need a toxicologist to run blood and urine samples on you from that point on..........:D

Why you ask Sofa?
Click to expand...

Uhm, no.

1. It's not like DNP binds to a specific receptor to attenuate. (clen, e.g., binds to the beta-2 and -3 (in animals) receptors which downregulate - not the case w/ DNP).

2. Not only do you not develop tolerance, but the converse is true - I'm pretty sure DNP's halflife is not a terminal-elimination one (obviously not biphasic either though) - yes, after the first 36 hours half is out of your system and yes, after another 36 a quarter of the original dose is out too. But anyone who's done a couple of cycles knows that even after a month layoff, all things equal, a dosage will kick in MUCH faster than the previous one. I think that's b/c DNP is lipophilic and your adipose tissue will make a nice home for those few mgs that didn't know about the halflife.

SG, you're pretty experienced with poison, so I'm guessing you ordered from a new source and are wondering why it's taking longer to kick in? I bet I can answer it... :-D
 
DaMan said:
SG, you're pretty experienced with poison, so I'm guessing you ordered from a new source and are wondering why it's taking longer to kick in? I bet I can answer it... :-D
Click to expand...

Sorry, Sherlock, but your assumption is wrong. :)

I'm honestly only asking because I've seen clen and ephedrine lose their efficacy. I wondered if the same was true with DNP.
 
I have seen a study posted on elite a while back , where several severly overwieght people took 200 mg every other day , combined with diet and excersice lost approx 3-4 lbs a week while on for a year . Do a search it was posted about a year ago .
 
DaMan said:


Uhm, no.

1. It's not like DNP binds to a specific receptor to attenuate. (clen, e.g., binds to the beta-2 and -3 (in animals) receptors which downregulate - not the case w/ DNP).

2. Not only do you not develop tolerance, but the converse is true - I'm pretty sure DNP's halflife is not a terminal-elimination one (obviously not biphasic either though) - yes, after the first 36 hours half is out of your system and yes, after another 36 a quarter of the original dose is out too. But anyone who's done a couple of cycles knows that even after a month layoff, all things equal, a dosage will kick in MUCH faster than the previous one. I think that's b/c DNP is lipophilic and your adipose tissue will make a nice home for those few mgs that didn't know about the halflife.

SG, you're pretty experienced with poison, so I'm guessing you ordered from a new source and are wondering why it's taking longer to kick in? I bet I can answer it... :-D
Click to expand...

Uhmm NO to YOU bro. Care to read some scientific PROOF to back this up?

Read the cite ItalianSta posted. Be sure to find this:
"In methods heretofore known to using dinitrophenol to induce weight loss, while initial daily dosages have usually been much less than the toxic amount, about 100-250 mg, as the treatment progressed the patient normally developed a tolerance for dinitrophenol and the dosage was increased to obtain the same results. This increased dosage led to an increased frequency of toxic symptoms and general disuse of dinitrophenol in inducing weight loss. "

Ummm sorry :rolleyes:
 
I think that the body can get used to almost all substances if they are taken frequently ... now it depends on what mean "frequently" with DNP ...
 
i just couldnt see someone using the stuff over and over for prolonged periods. eca is nothing for me anymore, i take 2-3 times the recomended label dose just to feel the same kick. havent used dnp very much at all but it sure kicks my ass.

just to add, ive tried two ways of using.
1st was a week long cycle, with the last 2-3 days were hard, very very sluggish and got very very hungry. but had no work and no school so it worked out great.
2nd, ive done this a few times, run it for 2-3-4 days. start heavy dose (400mg for me) on a monday, and taper down the next days. this way its much easier to keep diet in check, and by the time the weekend rolls around im refreshed and back to normal. did this for 4 weeks straight, very happy with results.
 
your body adjusts to things you put in it. people drink alcohol for long enough and their body combats it so they don't feel as drunk

the dnp question you are asking is like way over my head, but i'll bump for you
 
Yeah I agree............it's a shame there aren't too many GOOD reads on this stuff out there!!! It would definitely be nice to read some scientific perspectives as opposed to all the hypothetical guessing that we have to go on here!
 
this thread is very interesting to me since I have achieved zero fat loss from my last 3 dnp cycles that were all at 600 mgs a day for 10 to 14 days each....Ive always brought up the question of whether or not dnp could loose its effectiveness and everyone would always tell me that it wasnt possible...Id love to hear more about this...
 
Michael Corleone 21 said:
this thread is very interesting to me since I have achieved zero fat loss from my last 3 dnp cycles that were all at 600 mgs a day for 10 to 14 days each....Ive always brought up the question of whether or not dnp could loose its effectiveness and everyone would always tell me that it wasnt possible...Id love to hear more about this...
Click to expand...

Hm .. I wonder how you handled your diet.

There have been times when a lot of BAD info regarding DNP was being told to people. For a while people said do high carbs, then low carbs, etc etc.
 
Michael Corleone 21 said:
this thread is very interesting to me since I have achieved zero fat loss from my last 3 dnp cycles that were all at 600 mgs a day for 10 to 14 days each....Ive always brought up the question of whether or not dnp could loose its effectiveness and everyone would always tell me that it wasnt possible...Id love to hear more about this...
Click to expand...

There is no indication it would lose its effectiveness in just 10-14 days. If you were taking it for 10-14 at 600mgs per day... either your stuff was fake or your diet was bad.

DNP causes monster carb cravings. Unfortunately, you can't eat whatever you want. Hence, a lot of guys use DNP and don't lose an ounce because they can't control the carb cravings.

I don't have a link, but I ran a 32 day cycle boosting the dose up to 800mg crystal and found that I could out eat the drug so that I didn't lose any body fat. It was a deliberate experiment with see if I could offset the effect of the drug by over eating. I found it wasn't even that hard.
 
DNP does not lose it effects... in time your system may make metabolic changes to adapt.. though its inhibition of OP does not decrease.

DaMan is accurate in his description of the effects of subsequent and on going cycles with respect to lipid storage.


thus any "resistance" to DNP is not direct as such is impossible.

however.. excretion rates may rise.. and changes in your lipid environment (fat loss) will have effects as well.
 
SG: In another thread you said that you saw a study re calorie deficits w/ various metabolic "enhancers"... do you have that study lying around anywhere? I'm VERY curious.

BTW Macro I'm on T3 at the moment (the Decaman pyramid - day 5), out of on-topic curiosity, what do you think about adding 200mgs of "weed killer" (yes, I know) to it? I'm also on fina as far as thyroid goes and my last set of bloodwork showed tren suppresses TSH but rebounds quickly (no fat gain or sides so I don't really care)... I'm thinking since the thyroid already suppressed endo T3 production there is no danger in having DNP inhibiting T4-T3 conversion anymore... no?

(btw had bloodwork done on last decaman pyramid and it was all good)
 
SofaGeorge said:


There is no indication it would lose its effectiveness in just 10-14 days. If you were taking it for 10-14 at 600mgs per day... either your stuff was fake or your diet was bad.

DNP causes monster carb cravings. Unfortunately, you can't eat whatever you want. Hence, a lot of guys use DNP and don't lose an ounce because they can't control the carb cravings.

I don't have a link, but I ran a 32 day cycle boosting the dose up to 800mg crystal and found that I could out eat the drug so that I didn't lose any body fat. It was a deliberate experiment with see if I could offset the effect of the drug by over eating. I found it wasn't even that hard.
Click to expand...

OK...let me explain a little better...Alltogether Ive done around 7 dnp cycles all at 600 mgs a day for 10 to 14 days. The last 3 yielded zero fat loss and when I came off it I even ended up gaining fat faster than I usually do. My diet was that of low to moderate carbs , a good amount of protein and low fat...I kept cals at around 1800 to 2000 a day and Im 6'1 225 pds.......I dont really think I overate...during the cycles I actually thought I was undereating. Oh yea and the source was right on the money...they were from our fallen guru....
 
so in theory at 200mg a day it is slowly building up in your system...and i swear it take 2 weeks for dnp to clear out
 
OXANDRIN said:
so in theory at 200mg a day it is slowly building up in your system...and i swear it take 2 weeks for dnp to clear out
Click to expand...

yeah, exactly...here's a post I made awhile ago:

http://boards.elitefitness.com/forum/showthread.php?postid=2464904#post2464904

well, with a half-life of 36 hours it's gonna take a really long time to "clear" out of your body...

not 100% accurate, but too bad :-P

say on day one you take one, 200mg cap (and you're able to absorb 10)% of it).

on day 2 there will be ~132mg left

day 3 = ~87mg left
day 4 = ~57mg left
day 5 = ~37mg left
day 6 = ~25mg left
day 7 = ~16mg left
day 8 = ~10mg left
day 9 = ~7mg left
day 10 = ~4mg left
day 11 = ~3mg left
day 12 = ~2mg left
day 13 = ~1mg left
day 14 = ~.9mg left
day 15 = ~.5mg left
day 16 = ~.3mg left
day 17 = ~.2mg left
day 18 = ~.1mg left

and it just keeps falling from there...

so technically it's gonna be there for quite some time even if it's only in minute amounts.
 
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