does diabetes affect dnp progress?

[rnch]

my new work out partner commented that he had tried DNP and it worked well for him in the past, but didn't loose any bf the last time he tried. same supplier, same routine, same dosage.

he was recently daigonsed as boderline diabetic and is taking oral medication to successfully control it.

if his blood sugars levels were too high, could this be why he didn't loose any body fat on his last dnp run??

 

[nandi12]

It's possible but hard to say exactly because the action of DNP on glucagon, glucose transport into cells, and fatty acid synthesis is complex. DNP increases glucagon secretion, which raises blood sugar levels. On the other hand since the DNP is starving cells throughout the body for energy by blocking ATP production, cells increase their uptake of the elevated blood sugar.

In fat cells, the DNP blocks the synthesis fatty acids from the glucose they take up, so there would reach a point where they could not take up any more, regardless of high blood sugar levels. This could lead to dangerously high blood sugar levels, especially in a person suffering from diabetes.

DNP was originally used as a diet pill, but was discontinued when some people started developing cataracts. It is thought that cataracts are caused by the DNP induced hyperglycemia. Diabetics often get cataracts because of their elevated blood sugar.

Because these interactions are complex and potentially dangerous for a diabetic individual, I don't think it is wise to use DNP if you have diabetes.

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[rnch]

interesting logic, anyone else???

 

[rnch]

?

 

[nandi12]

Rnch, I reread you original post and something is not clear to me, and I have a question for you. On your friend's cycle when he noticed no fat loss, was that the first time he took his medication in conjuction with the DNP? On previous cycles when he got good results from the DNP he was not taking the medication?

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[rnch]

Rnch, I reread you original post and something is not clear to me, and I have a question for you. On your friend's cycle when he noticed no fat loss, was that the first time he took his medication in conjuction with the DNP? On previous cycles when he got good results from the DNP he was not taking the medication?

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i'll ask him today, we are supposed to work out this morning.

 

[argent]

This seems like a very good question, so bump for the post workout answer.

 

[firstenrgy]

Did he check his blood sugar regularly? Did he track his caloric intake during the diet? Without him doing those two things, we can only guess on what occured.
firstenrgy

 

[nandi12]

i'll ask him today, we are supposed to work out this morning

The reason I'm asking is I'm wondering if this might be what is going on:

I assume he is taking an oral hypoglycemic agent to improve insulin sensitivity. Prior to treatment he was most likely experiencing insulin resistance to some degree, a hallmark of type II diabetes. With insulin resistance, he is getting less glucose into his cells for fuel than a normal person, and relying more on fat burning for energey. Kind of like being on a ketogenic diet.

The DNP use would only amplify the fat burning, and without his medication he would have experienced dramatic fat loss.

Assuming the medicine has improved his insulin resistance, he is now able to utilize glucose more efficiently and glycolysis becomes a more important source of energy during DNP use, resulting in less of a demand on fat burning for fuel.

 

[rnch]

nandi 12:

back from the gym, talked with my work out partner:

his last dnp run was 300 per day for 30 days, lost almost nothing, this is what finally got him to get blood work done, 90 days after the last dnp cycle ended, and discovering he was diabetic. he is taking glucovance once per day, it is controlling the sugar levels successfully.

we both assume his blood sugars levels were too high during the last cycle, as he has did well on dnp last year. during the cycles his calorie intake was slightly higher than normal, more carbohydrates taken in.

he is ready to try another dnp "low and slow" run now that the blood sugars level problem is under control, just wondering if he should while taking the glucovance?

 

[nandi12]

There are several things to consider. The DNP will antagonize some aspects of the action of the Glucovance.

Glucovance is a combination of two agents, metformin and glyburide. The metformin lowers blood sugar by reducing glucose production in the liver and by increasing glucose uptake by cells. Impeding glucose absorption from the intestine is thought to be a mechanism as well.

Glyburide increases insulin production and increases insulin stimulated glucose transport into cells.

As you may know, the pancreas secretes glucagon in response to low blood sugar levels. Glucagon has the opposite action of insulin: it increases blood sugar by stimulating glucose production by the liver, and it inhibits insulin stimulated glucose transport into cells. So glucagon also has the opposite action of Glucovance

Where is all this going? It turns out that DNP increases glucagon production (1). This is why I originally said that DNP would antagonize the action of Glucovance, and one way it does it by stimulating glucagon production.

Even though DNP itself increases glucose uptake in cells in a normal person, the glucagon stimulated glucose production offsets this leading to hyperglycemia. (This is the reason DNP causes cataracts. In diabetics, cataracts often form as a result of long term uncontrolled hyperglycemia). This problem will only be exacerbated by your friends insulin resistance.

DNP also seems to block glyburide's ability to stimulate insulin secretion from the pancreas (2).

During a short course of DNP the elevated blood sugar would probably not be a problem. Unfortunately there are potentially more serious things to consider.

Lactic acidosis is a potential serious side effect of Metformin. DNP induces lactic acidosis as well. (DNP blocks oxidative phosphorylation in cells, forcing them to use the glycolytic pathway to produce ATP. Lactic acid is the end product.)

The combination of the metformin and DNP could lead to serious acidosis, especially in someone working out. (Lactic acid is what causes the burn from lifting, sprinting, etc.)

Another thing to consider is that the sulfonylurea drugs like glyburide are also mild mitochondrial uncouplers, like DNP. Combining the two could be like taking an extra strong dose of DNP, with potential dangerous side effects.



(1) Biochim Biophys Acta 1980 Mar 3;628(2):152-60

Effects of metabolic inhibitors on the regulation of pancreatic glucagon release.

Ostenson CG, Agren A, Andersson A.

(2) Am J Physiol 1998 Jan;274(1 Pt 1):E38-44

Metabolic inhibition impairs ATP-sensitive K+ channel block by sulfonylurea in pancreatic beta-cells.

Mukai E, Ishida H, Kato S, Tsuura Y, Fujimoto S, Ishida-Takahashi A, Horie M, Tsuda K, Seino Y.

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