Dr. M bingo! Its a matter of tolerating the side effects. Some people just can't hack it.
DT is hit the nail on the head as well. Worried about estragen on 5 grams of test? Try 5 mg of letro every day. Blood pressuring getting a bit high? 40 mg of lasix twice a day will handle it, and a bit of that pesky water retention from using 5 grams a week.
Want to eat like a pig on 10,000 cals a day like some pro's without getting that fat? Solution:
300 mg of tren ed
12+ iu's of hgh ed
100 mcg of t3 ed
100 mcg of clen ed
... when bulking and you will gain very little fat, even on 10K cals with a couple junk food meals every day. What it all comes down to, is how many drugs can you afford, and how much are you willing to risk pumping into your body. This is how the pro's solve their problems. Either higher doses of drugs or just add another drug to handle it.