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DNP for Dummies
- Thread starter smokinghawk
- Start date
how often can you cycle dnp if you only use 200mg/day? I have done 2 cycles with excellent results 6 months apart and am wondering if it is unsafe for me to use this again, and what the time frame is that you should wait if it is safe for me to use again since it is so hard on your system. I have more but am wondering if i should just call it quits for awhile.
smokinghawk
New member
I think how long between cycles is a matter of choice, EXCEPT if you've added T3 like a lot of people do now. Then you should give yourself full thyroid recovery, since that's the limiting factor on how effective a DNP run can be. But then we also get into picky questions like:
What if I use forskolin or guggul to recover the thyroid? Can I cut the waiting time before my next run?
Does how long my cycle is affect how long I should wait until next time?
Whatif I use bromocriptine to recover my metabolism afterward? (I'm going to be researching that question when I get back from vacation in a week or so).
Benadryl doesn't need to be front-loaded unless you already know DNP breaks you out. Epsom salt baths and extra ALA can also help with skin breakouts.
What if I use forskolin or guggul to recover the thyroid? Can I cut the waiting time before my next run?
Does how long my cycle is affect how long I should wait until next time?
Whatif I use bromocriptine to recover my metabolism afterward? (I'm going to be researching that question when I get back from vacation in a week or so).
Benadryl doesn't need to be front-loaded unless you already know DNP breaks you out. Epsom salt baths and extra ALA can also help with skin breakouts.
smokinghawk
New member
Creating your own capsules
This is just a narrative of my own best experiences with this, for those who don't want to trust the capping of a source, or can obtain raw powder on their own. How you obtain that is up to you; I won't even hint at a source for it.
Another advantage to self-capping is that you can use useful filler instead of just corn starch. For example, I fill mine with 250mg DNP and the rest with fruit antioxidant powder--that's IN ADDITION to the caps full of fruit antioxidants I take 2-3x day anyways. Or you could use alpha lipoic acid, or grape seed extract, or ellagic acid, or whatever useful product you'd like.
While cap-m-quik machines are standard, I personally prefer another device from www.capsuleconnection.com called the "Capping machine," size 0. The reason is this: the capping machine will apply capsules tops automatically in a one-motion press of the top tray, instead of having to hand-apply each capsule top one at a time with the cap-m-quik. That minimizes spilled powder and doesn't exspose your hands to 50 individual opened capsules. Be sure to practice a lot of times first so you'll get the smooth, even pressure motion down. Otherwise you'll inevitably crush and break a few capsules. Hint: don't overfill them (too much filler squeezes rhe sides outward, making them harder to cap properly).
DNP will stain anything vivid yellow even in proximity; hands look like you've been drawn all over by a highlighter pen. I had no trouble removing most stains with a fast trip to soap and water, but protective gloves are essential. Regular latex examination gloves are cheap and easy to get; wear double layers. Surgical gloves are more expensive and harder to find, but better protection--a single pair will protect you (thanks, Elite bros, for this tip!).
You'll need a precise--PRECISE--scale. My choice; the MX-120 digital scale, $38 from www.americanweigh.com. Deering beam scales are also fine.
The capping machine makes 24 capsules at once. Here's how to make 24 capsules of 250mg DNP with other filler of your choice
This begins with exactly 6 grams of DNP, which will divide into 250mg (6/24). Each size 0 capsule holds about 300-500mg total, so you'll need about 8 grams total, so that means you'll add 2 grams of filler. I made a mix of exactly 6 grams DNP and 2 grams fruit antioxidants. These 8 grams fit PERFECTLY into the size 0 capsules with no leftover, creating 24 capsules of 350mg (volume and weight are different; even though size 0 says it'll hold up to 500mg, 8 grams of my powder was a precise fill).
I'll omit directions on how to operate the machine.
Each capsule weighed exactly 400mg total, including the gelatin cover, when it was finished. It took 5 minutes.
For a cap-m-quik, if you insist on using it, here are size 0 calculations:
50 capsules will take 10 grams of DNP, or exactly 200mg DNP per capsule. Since each capsule will actually hold 350-400mg, you'll need to add 7.5 grams of extra powder to create the 17.5 grams that will evenly fill 50 capsules at 350mg each.
Expect to lose a small amount of powder as you individually cap each capsule; this is neglibile and I'd just discard it.
Next installment: What research is there about whether DNP is safe? (I encourage ALL Elite friends who have research to add to this!).
This is just a narrative of my own best experiences with this, for those who don't want to trust the capping of a source, or can obtain raw powder on their own. How you obtain that is up to you; I won't even hint at a source for it.
Another advantage to self-capping is that you can use useful filler instead of just corn starch. For example, I fill mine with 250mg DNP and the rest with fruit antioxidant powder--that's IN ADDITION to the caps full of fruit antioxidants I take 2-3x day anyways. Or you could use alpha lipoic acid, or grape seed extract, or ellagic acid, or whatever useful product you'd like.
While cap-m-quik machines are standard, I personally prefer another device from www.capsuleconnection.com called the "Capping machine," size 0. The reason is this: the capping machine will apply capsules tops automatically in a one-motion press of the top tray, instead of having to hand-apply each capsule top one at a time with the cap-m-quik. That minimizes spilled powder and doesn't exspose your hands to 50 individual opened capsules. Be sure to practice a lot of times first so you'll get the smooth, even pressure motion down. Otherwise you'll inevitably crush and break a few capsules. Hint: don't overfill them (too much filler squeezes rhe sides outward, making them harder to cap properly).
DNP will stain anything vivid yellow even in proximity; hands look like you've been drawn all over by a highlighter pen. I had no trouble removing most stains with a fast trip to soap and water, but protective gloves are essential. Regular latex examination gloves are cheap and easy to get; wear double layers. Surgical gloves are more expensive and harder to find, but better protection--a single pair will protect you (thanks, Elite bros, for this tip!).
You'll need a precise--PRECISE--scale. My choice; the MX-120 digital scale, $38 from www.americanweigh.com. Deering beam scales are also fine.
The capping machine makes 24 capsules at once. Here's how to make 24 capsules of 250mg DNP with other filler of your choice
This begins with exactly 6 grams of DNP, which will divide into 250mg (6/24). Each size 0 capsule holds about 300-500mg total, so you'll need about 8 grams total, so that means you'll add 2 grams of filler. I made a mix of exactly 6 grams DNP and 2 grams fruit antioxidants. These 8 grams fit PERFECTLY into the size 0 capsules with no leftover, creating 24 capsules of 350mg (volume and weight are different; even though size 0 says it'll hold up to 500mg, 8 grams of my powder was a precise fill).
I'll omit directions on how to operate the machine.
Each capsule weighed exactly 400mg total, including the gelatin cover, when it was finished. It took 5 minutes.
For a cap-m-quik, if you insist on using it, here are size 0 calculations:
50 capsules will take 10 grams of DNP, or exactly 200mg DNP per capsule. Since each capsule will actually hold 350-400mg, you'll need to add 7.5 grams of extra powder to create the 17.5 grams that will evenly fill 50 capsules at 350mg each.
Expect to lose a small amount of powder as you individually cap each capsule; this is neglibile and I'd just discard it.
Next installment: What research is there about whether DNP is safe? (I encourage ALL Elite friends who have research to add to this!).
Last edited:
smokinghawk
New member
Is DNP safe?
Here's my research. This is AMAZING! Not only has not a single test found it to be carcinogenic, but test after tyest after test find that DNP actually ATTACKS cancer cells, and helps anti-cancer medications work better, and helps anti-leukemia medications work without destroying cell DNA, and suppresses tumor growth by 20-50%. The summaries are all right here, friends. Karma me up!
DNP is Ames negative, and does not promote tumors. See for yourself at http://toxnet.nlm.nih.gov/
http://www.epa.gov/ttn/atw/hlthef/dinitrop.html reports on health risks. While there have not been human studies, animal studies found no cancers caused by DNP administration. It is considered a toxin because it causes nausea, sweating, and weight loss.
http://www.cyberiron.com/drugs/dinitrophenol.html reports on halth risks from external exposue. In other words, don’t get it in your eyes, or on your skin if you’re allergic. Pretty elementary stuff.
http://www.ebec2000.com/abstracts/056.htm This animal study documents a 64% increase in metabolism. "These findings confirm that DNP effectively increases metabolic rate..." Duh.
http://www.zymed.com/pdf/04-xxxx/04-8300.pdf A PDF file about an antidote to DNP.
http://www.boehringer-ingelheim.es/workshop-methionina/anglesa/cap13.htm finds that DNP did not activate liver enzymes (MAT) associated with liver damage
"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats." Koizumi M, Yamamoto Y, Ito Y, Takano M, Enami T, Kamata E, Hasegawa R. Division of Risk Assessment, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. This study found that DNP can induce death in overdosed amounts, but that up to that point no toxicity was evident, nor were there any abnormalities in physical development.
"Phenol toxicity and conjugation in human colonic epithelial cells." Pedersen G, Brynskov J, Saermark T. Dept of Medical Gastroenterology, Herlev University Hospital, Copenhagen, Denmark.. This study found that DNP has a toxic effect on cells of the colon, with "toxic" defined in two ways: first, it interfered with metabolism (this we know—it’s the intended effect of DNP users!) and second, it interfered with bowel inflammation (not a health risk. This is caused by osmotic effect, with the worst results being softened stools and gas).
"Mechanisms of bacterial resistance to macrolide antibiotics." Nakajima Y. Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan. This study found that antibiotic-resistant bacteria could be thwarted with DNP. "the extent of the accumulated drug in a resistant cell increases as much as that in a susceptible cell in the presence of an uncoupling agent such as…2,4-dinitrophenol (DNP)."
"Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors." Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB. Departments of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Check this out—DNP actually helps make melanoma tumors easier to attack by increasing ratio of oxygen consumption to lactic acid production, while glycolysis remains the same. "Therefore, tumor acute acidification and oxygenation can be achieved by exposure…"
"New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy."
Molenaar C, Teuben JM, Heetebrij RJ, Tanke HJ, Reedijk J. Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands. DNP is used as a control in tests of antitumor cells because it does NOT bind to cell DNA, nor promote tumors, yet its staining abilities enable tracking of the uptake of antitumor drugs.
Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it’s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer…fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP can be synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.
"Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity." Neuhaus-Steinmetz U, Rensing L. Institute of Cell Biology, Biochemistry and Biotechnology, NW II University of Bremen, Germany. The thermic effect of DNP induces protein synthesis (heat shock protein, or HSP, synthesis). In fact, it’s quite GOOD at it: "ASA, DNP and CCCP induced HSP at lower concentrations than substances with a similar lipophilicity…"
"Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetate on mouse neuroblastoma cells in vitro." Andres MI, Repetto G, Sanz P, Repetto M.
National Institute of Toxicology, Seville, Spain. In this study, DNP’s observed effect was an increase in metabolism (duh!), while the other toxins compared to it had harmful in vitro effects but no increase in metabolism.
"Inhibition of uncoupled respiration in tumor cells. A possible role of mitochondrial Ca2+ efflux." Gabai VL.Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. DNP not only does not cause tumors, but it inhibited their respiration by 20-25% compared to controls.
"Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol." Shibuya ML, Buddenbaum WE, Don AL, Utsumi H, Suciu D, Kosaka T, Elkind MM. Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523. In this study, researchers found that DNP abrogates—or disrupts—cytotoxicity in hamsters (using cancerous cells). They expected to find that DNP would interfere with anticancer treatments, but instead found that DNP increased their effects. They state, though, that they cannot claim a proven effect of DNP on anticancer treatments yet, although they do agree that treatment with DNP actually enhanced the effects of the DNA regenerative therapy of anticancer chemotherapy.
"Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note." Kaufmann SH. Oncology Center, Johns Hopkins Hospital, Baltimore, Maryland 21205. The authors warn that certain anti-leukemia drugs resulted in "extensive DNA degradation." BUT (good ol’ DNP to the rescue!), "Preincubation with dinitrophenol abolished the effect…"
"[Dependence of the nature of the action of metabolic inhibitors on ribosomal RNA synthesis in Ehrlich ascites carcinoma cells on cell integrity]" [Article in Russian] Akhlynina TV, Buzhurina IM, Panov MA, Rozovskaia IA, Chernaia NG. DNP actually inhibits the synthesis of RNA in carcinoma cells. In other words, it helps cancerous cells commit suicide by neutering themselves. "Ribosomal RNA (rRNA) synthesis in the intact Ehrlich ascite carcinoma cells is selectively inhibited by papaverin (ED50 = 0.01 mM), 2,4-dinitrophenol (DPN; ED50 = 5 microM), and actinomycin D (ED50 = 0.1 microgram/ml)."
"Autocatabolism of surface macromolecules shed by human melanoma cells." Bystryn JC, Perlstein J. Cancer Res 1982 Jun;42(6):2232-7. This study finds that DNP helps melanoma cells die (autocatabolize) while other cells are unaffected.
http://www.geocities.com/byggdegstor/dnpforside - tons of research, including medical studies. Excerpts:
DNP does not cause liver damage: "Their analyses demonstrate, beyond a doubt, that the liver does not suffer any damage in the course of dinitro treatment." (Biological Study of Dinitro Drugs in Humans By Dr. Jacques Bell. Bell, Jacques. 1939. Etude biologique des produits dinitres chez l'homme. Medecine. 19:749-54. Translation © 1996 Robert Ames)
Also: "Experimental studies on animals do not show toxic effects of dinitrophenol on the kidney. Anatomical-pathological examinations of animals, even those which died from a massive dose of dinitrophenol, do not reveal any important anatomical changes, except a small degree of cytolysis. Clinical documents are not abundant, but, on the whole, do not seem to demonstrate that dinitrophenol is toxic for the kidneys."
"Dinitrophenol has almost no action on the blood cholesterol. (Grant and Schube)."
"it doesn't seem that dinitrophenol at usual clinical doses is likely to harm the kidneys."
"Dinitrophenol is remarkable for its absence of effect on the cardio-vascular system...dinitrophenol is absolutely devoid of toxicity for the heart."
"Dinitrophenol does not attack cell tissue albumin and does not determine the fat loss to the expense of the muscles, contrary to thyroxine."
"dinitrophenol offers this precious advantage that the cessation of its use at the slightest appearance of signs indicating an imminence of intoxication results immediately in the arrest of those symptoms." (Professor Pouchet)."
Interestingly, one medical theory on a health ADVANTAGE of DNP is that the slight increase in thermogenic temperature simulates the fever a body induces during a viral attack. The body increases itsheat to protect organs but kill viruses, and some theorize that DNP can do the same thing, thus killing viruses in the body. In this mechanism, DNP may have an immune-enhancing effect.
Here's my research. This is AMAZING! Not only has not a single test found it to be carcinogenic, but test after tyest after test find that DNP actually ATTACKS cancer cells, and helps anti-cancer medications work better, and helps anti-leukemia medications work without destroying cell DNA, and suppresses tumor growth by 20-50%. The summaries are all right here, friends. Karma me up!
DNP is Ames negative, and does not promote tumors. See for yourself at http://toxnet.nlm.nih.gov/
http://www.epa.gov/ttn/atw/hlthef/dinitrop.html reports on health risks. While there have not been human studies, animal studies found no cancers caused by DNP administration. It is considered a toxin because it causes nausea, sweating, and weight loss.
http://www.cyberiron.com/drugs/dinitrophenol.html reports on halth risks from external exposue. In other words, don’t get it in your eyes, or on your skin if you’re allergic. Pretty elementary stuff.
http://www.ebec2000.com/abstracts/056.htm This animal study documents a 64% increase in metabolism. "These findings confirm that DNP effectively increases metabolic rate..." Duh.
http://www.zymed.com/pdf/04-xxxx/04-8300.pdf A PDF file about an antidote to DNP.
http://www.boehringer-ingelheim.es/workshop-methionina/anglesa/cap13.htm finds that DNP did not activate liver enzymes (MAT) associated with liver damage
"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats." Koizumi M, Yamamoto Y, Ito Y, Takano M, Enami T, Kamata E, Hasegawa R. Division of Risk Assessment, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. This study found that DNP can induce death in overdosed amounts, but that up to that point no toxicity was evident, nor were there any abnormalities in physical development.
"Phenol toxicity and conjugation in human colonic epithelial cells." Pedersen G, Brynskov J, Saermark T. Dept of Medical Gastroenterology, Herlev University Hospital, Copenhagen, Denmark.. This study found that DNP has a toxic effect on cells of the colon, with "toxic" defined in two ways: first, it interfered with metabolism (this we know—it’s the intended effect of DNP users!) and second, it interfered with bowel inflammation (not a health risk. This is caused by osmotic effect, with the worst results being softened stools and gas).
"Mechanisms of bacterial resistance to macrolide antibiotics." Nakajima Y. Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan. This study found that antibiotic-resistant bacteria could be thwarted with DNP. "the extent of the accumulated drug in a resistant cell increases as much as that in a susceptible cell in the presence of an uncoupling agent such as…2,4-dinitrophenol (DNP)."
"Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors." Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB. Departments of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Check this out—DNP actually helps make melanoma tumors easier to attack by increasing ratio of oxygen consumption to lactic acid production, while glycolysis remains the same. "Therefore, tumor acute acidification and oxygenation can be achieved by exposure…"
"New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy."
Molenaar C, Teuben JM, Heetebrij RJ, Tanke HJ, Reedijk J. Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands. DNP is used as a control in tests of antitumor cells because it does NOT bind to cell DNA, nor promote tumors, yet its staining abilities enable tracking of the uptake of antitumor drugs.
Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it’s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer…fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP can be synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.
"Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity." Neuhaus-Steinmetz U, Rensing L. Institute of Cell Biology, Biochemistry and Biotechnology, NW II University of Bremen, Germany. The thermic effect of DNP induces protein synthesis (heat shock protein, or HSP, synthesis). In fact, it’s quite GOOD at it: "ASA, DNP and CCCP induced HSP at lower concentrations than substances with a similar lipophilicity…"
"Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetate on mouse neuroblastoma cells in vitro." Andres MI, Repetto G, Sanz P, Repetto M.
National Institute of Toxicology, Seville, Spain. In this study, DNP’s observed effect was an increase in metabolism (duh!), while the other toxins compared to it had harmful in vitro effects but no increase in metabolism.
"Inhibition of uncoupled respiration in tumor cells. A possible role of mitochondrial Ca2+ efflux." Gabai VL.Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. DNP not only does not cause tumors, but it inhibited their respiration by 20-25% compared to controls.
"Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol." Shibuya ML, Buddenbaum WE, Don AL, Utsumi H, Suciu D, Kosaka T, Elkind MM. Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523. In this study, researchers found that DNP abrogates—or disrupts—cytotoxicity in hamsters (using cancerous cells). They expected to find that DNP would interfere with anticancer treatments, but instead found that DNP increased their effects. They state, though, that they cannot claim a proven effect of DNP on anticancer treatments yet, although they do agree that treatment with DNP actually enhanced the effects of the DNA regenerative therapy of anticancer chemotherapy.
"Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note." Kaufmann SH. Oncology Center, Johns Hopkins Hospital, Baltimore, Maryland 21205. The authors warn that certain anti-leukemia drugs resulted in "extensive DNA degradation." BUT (good ol’ DNP to the rescue!), "Preincubation with dinitrophenol abolished the effect…"
"[Dependence of the nature of the action of metabolic inhibitors on ribosomal RNA synthesis in Ehrlich ascites carcinoma cells on cell integrity]" [Article in Russian] Akhlynina TV, Buzhurina IM, Panov MA, Rozovskaia IA, Chernaia NG. DNP actually inhibits the synthesis of RNA in carcinoma cells. In other words, it helps cancerous cells commit suicide by neutering themselves. "Ribosomal RNA (rRNA) synthesis in the intact Ehrlich ascite carcinoma cells is selectively inhibited by papaverin (ED50 = 0.01 mM), 2,4-dinitrophenol (DPN; ED50 = 5 microM), and actinomycin D (ED50 = 0.1 microgram/ml)."
"Autocatabolism of surface macromolecules shed by human melanoma cells." Bystryn JC, Perlstein J. Cancer Res 1982 Jun;42(6):2232-7. This study finds that DNP helps melanoma cells die (autocatabolize) while other cells are unaffected.
http://www.geocities.com/byggdegstor/dnpforside - tons of research, including medical studies. Excerpts:
DNP does not cause liver damage: "Their analyses demonstrate, beyond a doubt, that the liver does not suffer any damage in the course of dinitro treatment." (Biological Study of Dinitro Drugs in Humans By Dr. Jacques Bell. Bell, Jacques. 1939. Etude biologique des produits dinitres chez l'homme. Medecine. 19:749-54. Translation © 1996 Robert Ames)
Also: "Experimental studies on animals do not show toxic effects of dinitrophenol on the kidney. Anatomical-pathological examinations of animals, even those which died from a massive dose of dinitrophenol, do not reveal any important anatomical changes, except a small degree of cytolysis. Clinical documents are not abundant, but, on the whole, do not seem to demonstrate that dinitrophenol is toxic for the kidneys."
"Dinitrophenol has almost no action on the blood cholesterol. (Grant and Schube)."
"it doesn't seem that dinitrophenol at usual clinical doses is likely to harm the kidneys."
"Dinitrophenol is remarkable for its absence of effect on the cardio-vascular system...dinitrophenol is absolutely devoid of toxicity for the heart."
"Dinitrophenol does not attack cell tissue albumin and does not determine the fat loss to the expense of the muscles, contrary to thyroxine."
"dinitrophenol offers this precious advantage that the cessation of its use at the slightest appearance of signs indicating an imminence of intoxication results immediately in the arrest of those symptoms." (Professor Pouchet)."
Interestingly, one medical theory on a health ADVANTAGE of DNP is that the slight increase in thermogenic temperature simulates the fever a body induces during a viral attack. The body increases itsheat to protect organs but kill viruses, and some theorize that DNP can do the same thing, thus killing viruses in the body. In this mechanism, DNP may have an immune-enhancing effect.
MrQuestion
Banned
Good shit. I wish I can give you more karma.
I had to finish my DNP+bromo cycle early since I caught the stupid flu bug. Ill report my results soon with the details and skinfold measurements. I even did a horizontal measurement on my ab skinfold just for kicks on top of the vertical measurement. Can I get an "ooooh....ahhh" in here?
Let's just say that my theory is correct, well...on me that is
And the fat was coming off really fast by the day.
I had to finish my DNP+bromo cycle early since I caught the stupid flu bug. Ill report my results soon with the details and skinfold measurements. I even did a horizontal measurement on my ab skinfold just for kicks on top of the vertical measurement. Can I get an "ooooh....ahhh" in here?
Let's just say that my theory is correct, well...on me that is
And the fat was coming off really fast by the day.MrQuestion
Banned
One thing I want to add. For the past several years, I always get the flu bug early into the summer, late spring for some reason. USually im very sick, feeling ulta shity, have a bad throat infection, headaches, etc.
This time around, I actually feel ok. I did 'stop' the bromo-DNP cycle to allow full recovery from my flu but this is the first time where Im not 'too' sick.
This time around, I actually feel ok. I did 'stop' the bromo-DNP cycle to allow full recovery from my flu but this is the first time where Im not 'too' sick.
MrQuestion
Banned
Here is another one done by a doctor whom Dan Duchaine respected a lot and I think had learned DNP from.
If you look at the link, Doctor Nick done extensive tests on the kidneys, liver, etc. On the first issue of Dirty Dieting, Duchaine stated that none of the tests showed any damage to those organs.
http://patft.uspto.gov/netacgi/nph-...1&S1=4673691.WKU.&OS=PN/4673691&RS=PN/4673691
Case 1
A white female 31 years of age with a weight in excess of 200 pounds had attempted to loss weight with various diet plans. She had only been able to achieve about a 20-pound loss, and had immediately regained the weight. The patient was nulliparous and had no ongoing medical problems. Upon physical examination, she had a weight of 208.5 pounds, a height of 5 feet, 3 inches, and a blood pressure of 132/80, without any goiter. Laboratory analyses, including complete blood count, liver profile, serum electrolytes, kidney function tests and thyroid function tests, were all within normal limits. Because of her familial history of heart disease, she underwent a stress electrocardiogram which was normal other than early fatigue and calf cramping.
The patient was started on CYTOMEL brand of liothyronine sodium (manufactured by Smith, Kline and French), 50 mcg/day p.o., and on 2,4-dinitrophenol, 250 mg every other day p.o. On the 19th day of medication, the patient had normal vital signs and the dosages were increased to 100 mcg/day liothyronine, and 250 mg/day dinitrophenol alternated every other day with 125 mg/day. The patient was subsequently maintained on these dosages and returned for follow-up examinations approximately every 3 weeks. The weight loss history is seen in Table 1. After 241 days of medication, the patient has achieved her weight goal of 135 pounds. Administration of the dinitrophenol was discontinued and the patient was maintained on liothyronine, 100 mcg/day p.o. No weight gain was subsequently observed.
If you look at the link, Doctor Nick done extensive tests on the kidneys, liver, etc. On the first issue of Dirty Dieting, Duchaine stated that none of the tests showed any damage to those organs.
http://patft.uspto.gov/netacgi/nph-...1&S1=4673691.WKU.&OS=PN/4673691&RS=PN/4673691
Case 1
A white female 31 years of age with a weight in excess of 200 pounds had attempted to loss weight with various diet plans. She had only been able to achieve about a 20-pound loss, and had immediately regained the weight. The patient was nulliparous and had no ongoing medical problems. Upon physical examination, she had a weight of 208.5 pounds, a height of 5 feet, 3 inches, and a blood pressure of 132/80, without any goiter. Laboratory analyses, including complete blood count, liver profile, serum electrolytes, kidney function tests and thyroid function tests, were all within normal limits. Because of her familial history of heart disease, she underwent a stress electrocardiogram which was normal other than early fatigue and calf cramping.
The patient was started on CYTOMEL brand of liothyronine sodium (manufactured by Smith, Kline and French), 50 mcg/day p.o., and on 2,4-dinitrophenol, 250 mg every other day p.o. On the 19th day of medication, the patient had normal vital signs and the dosages were increased to 100 mcg/day liothyronine, and 250 mg/day dinitrophenol alternated every other day with 125 mg/day. The patient was subsequently maintained on these dosages and returned for follow-up examinations approximately every 3 weeks. The weight loss history is seen in Table 1. After 241 days of medication, the patient has achieved her weight goal of 135 pounds. Administration of the dinitrophenol was discontinued and the patient was maintained on liothyronine, 100 mcg/day p.o. No weight gain was subsequently observed.
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