DIM to reduce esto "naturally"

[thelion2005]

My Doctor has recommended DIM to reduce esto.

My next blood test is in Jan 2006 and I'll know if daily intake of this product has changed anything.

If nothing else, I'll be getting my veggies.

"DIM is diindolymethane, a phytonutrient found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale.

Unlike other plant nutrients such as soy isoflavones, diindolymethane has unique hormonal benefits. It supports the activity of enzymes that improve estrogen metabolism. Scientific research shows diindolylmethane increases the level of "good" estrogens (2-hydroxyestrogen) while reducing the level of "bad" estrogens (16-hydroxyestrogen). "

 

[temetrepo]

Good info. Man you are looking into every resource avialble, good.

 

[MikeMartial]

I've heard of DIM in regards to cruciferous vegetables and increased libido, but just anecdotal stories.

Is it available OTC in supplement form?

 

[Lifterforlife]

Some research I found on DIM....potentially aid in estrogen deactivation and evacuation. It does so by inhibiting the conversion enzyme responsible for 16a-Hydroxyestrone formation. This then forces the body to utilize the C-2 pathway and increase the production of 2a-Hydroxyestrone. The body then excretes the inactive metabolite of 2a-Hydroxyestone rather quickly and effectively. This results in less total circulatory estrogens as well.

Seems Indol-3 carbinol works in this identical manner.

 

[Lifterforlife]

By the way, in reference to my above post, credit must be given where it is due. Lion informed me about DIM, I took it upon myself to go out and research it. Thanks Lion for the heads up.

 

[Lifterforlife]

Seems like Dr. John is recommending TMG along with DIM for proper metabolism of estrogen.

Trimethylglycine (TMG, also known as anhydrous betaine), a highly effective methyl donor extracted from sugar beets. Methyl donors, such as TMG and folic acid, are required for the reduction of homocysteine back into methionine and for the accurate synthesis of DNA and RNA, which is essential for the production of normal cells. Methylation is inhibited by inadequately functioning key enzymes, excessive protein and fat intake, poor diet, inadequate intake of methyl groups, coffee, alcohol or by smoking. Impairment of methylation results in abnormal cell synthesis and elevated levels of homocysteine, a toxic amino acid and a serious health risk.

 

[MikeMartial]

Awesome research, Lifterforlife. Thanks for posting all that!!

2 Questions:

1) Is TMG easily available like DIM?

2) And does one have to cycle DIM, or can it be continuosly taken?

 

[thelion2005]

Interesting ... I am taking both. The TMG was supposed to be for circulation. The DIM for esto.

I admit I have no research beyond the internet hits. Nothing to lose because both are cheap from Vitamine World.

I'm just taking them ed like a vitamine. I hope they work.

 

[Lifterforlife]

Seems TMG is taken more as a "safety factor" to help in ridding substances created in the DIM metabolism / conversion process.

This is from Dr. John.....I have seen several studies which showed that while DIM improves the 2-OHE/16-a-OHE ratio, it also increases the bad 4-OHE. TMG, or its child DMG (although TMG is much better because it has already donated a valuable methyl group by the time it becomes DMG) will help flush the 4-OHE downstream.

Taking TMG/DMG is important on its own, even in absence of DIM supplementation. But I would not take DIM without it.

Why there would be controversy about this escapes me.