Actually, there is no evidence that this will ever happen. It doesn't have to do with cell replacement but brain chemistry. Your brain becomes more or less wired in such a way that it only feels normal at a certain bodyfat %/weight and will do anything it can to maintain this level. Even studies in rats show no adaption to a lower set point, which would occur faster in them since their bodies adapt much quicker than humans.
To make it even worse, there is evidence that the set point CAN be raised, mainly from what your mother ate when she was pregnant, and what you were fed as a baby, and ate during your developmental years up into your teens. Even at an older age, the set point can go up but hasn't been shown in any cases to go down.
Being NATURAL (no juice) and staying well below your setpoint will be a lifetime struggle to some degree. It will require constantly staying on a diet, from somewhat to severly screwed hormone levels, possible sexual dysfunction, low energy, constant hunger, etc. Much of this has to do with Leptin which controls many of the negative effects experienced during dieting. One way to try and keep things "normal" is frequent refeeds, especially as you get leaner. Maintaining Leptin during dieting seems to be a key to keeping the body from detecting too much of a disruption, allowing you to function better and keep the fat off long term. Does this suck, yes, big time. Is it possible to maintain, yes. It just doesn't happen readily, I believe 95% of people eventually fail on a given diet and gain the weight back. Thats why I think refeeds are so important, not only physiologically, but also psychologically. Not being allowed to cheat on a diet for weeks or months on end will result in serious bingeing/fat gain at some point. Just ask any precontest bodybuilder, being hardcore like that can do more harm than good. Its important to follow something you can live with, and right now i'm on such a plan that is cake to follow and works great as well.
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