DHT and Inhibition

[jonny jacked]

One of the most significant side effects of steroid use is inhibition of natural test. We know that elevated hormone levels, elevated estrogen levels and elevated DHT levels cause inhibition. So, we take Cytadren as an aromatase inhibitor, clomid to block estrogen, but these two are not where my question lies.
Now this may be completely wrong and off the charts but doesn’t propecia work by blocking DHT? If so, would it be reasonable to say that propecia could help raise endogenous testosterone levels? – this thought just occurred to me, and I posted it before even thinking it completely through, (probably a mistake).
What does everyone think?

 

[Singleton]

I wonder too.

Nelson's sometimes talking about how DHT keeps estrogen low. Lower estrogen keeps T higher, so it probablly balances out. Though I don't really know.

Can someone explain it?

 

[thx9000]

After a year of propecia use, men in Merck's study showed a 15% increase in total test and estradiol.

 

[twistedneck]

DHT is shown to inhibit natural test, lower free Test, and leave shbg unchanged. Now this is DHT gel, not Proviron, Masteron or Winny.

Proviron/Masteron/Winny are all DHT type compounds but they are all completely different in effects from actual DHT.

The only one that improves libido and increases Free T is Proviron. Masteron is known for increased agressiveness and leans you out w/o increasing E. Winny works as anti-prolactin. The only thing they all have in common is they dont bloat.

 

[jonny jacked]

bump this for more replies

 

[twistedneck]

To answer this question properly we need to know where DHT is active. It's not active in muscle, it is active in the skin (scalp) and prostate. But where else? Somewhere in the HPTA, cause its androgenic and shuts you down.

Where else is DHT active (ie. when it binds to the AR or covers HP, what happens?)

 

[buckwheat1]

To answer this question properly we need to know where DHT is active. It's not active in muscle, it is active in the skin (scalp) and prostate. But where else? Somewhere in the HPTA, cause its androgenic and shuts you down.

Where else is DHT active (ie. when it binds to the AR or covers HP, what happens?)

THX9000 already answered it. Decreasing DHT increased test and E by 15% in studies with propecia/proscar.

 

[thx9000]

To answer this question properly we need to know where DHT is active. It's not active in muscle, it is active in the skin (scalp) and prostate. But where else? Somewhere in the HPTA, cause its androgenic and shuts you down.

Where else is DHT active (ie. when it binds to the AR or covers HP, what happens?)

DHT is a CNS stimulant so there's another place its active. If you dont have to inhibit its production you shouldn't. Taking propecia for 15% increase in baseline T is silly.

 

[jonny jacked]

DHT is a CNS stimulant so there's another place its active. If you dont have to inhibit its production you shouldn't. Taking propecia for 15% increase in baseline T is silly.

good point. but i'm going to take it because my hair won't stop falling out. fucking test!

 

[Sigmund Roid]

DHT is shown to inhibit natural test, lower free Test, and leave shbg unchanged. Now this is DHT gel, not Proviron, Masteron or Winny.

Proviron/Masteron/Winny are all DHT type compounds but they are all completely different in effects from actual DHT.

The only one that improves libido and increases Free T is Proviron. Masteron is known for increased agressiveness and leans you out w/o increasing E. Winny works as anti-prolactin. The only thing they all have in common is they dont bloat.

Actually DHT, proviron, masteron are very alike. Masteron for sure increases libido, haven't you used it? Winny is quite different from DHT (it has an extra (pyrazol) ring on carbons 2 and 3), and it is not very comparable to the former 3 substances which only have an extra methyl group (except DHT). Also I think that masteron has at least some anti-aromatase actions just like proviron or DHT.

 

[twistedneck]

I'm learning again by reading Sigmund's posts, bro you are full of DHT knoledge..

I have not tried masteron yet. I'm ready for it though sounds like the best thing since Sten. Even though Sten didn't have DHT.

Some people also say Primo is DHT like, similar to Winny in this regard?

 

[bicepts101]

Actually DHT, proviron, masteron are very alike. Masteron for sure increases libido, haven't you used it? Winny is quite different from DHT (it has an extra (pyrazol) ring on carbons 2 and 3), and it is not very comparable to the former 3 substances which only have an extra methyl group (except DHT). Also I think that masteron has at least some anti-aromatase actions just like proviron or DHT.

....

 

[tommboy]

does finasteride (propecia) hurt strength gains? Because it lowers DHT levelsc

 

[krishna]

If you inhibit DHT (which will kill your libido), more of the test will aromatize and cause higher estrogen levels. This is why a side effect of adovart and finasteride is gynocomastia. There is no way I would lower my DHT levels unless it was for hair salvation purposes.

 

[tommboy]

so you gotta run double the anti E's when on finasteride?

 

[krishna]

I don't know about double, but I would make sure you use something; preferably an aromatase inhibitor such as a-dex or letro.

 

[tommboy]

yea i was using .5 mg adex ed but it wasn't enough so I added 20 mg nolva ed.



so let me get the science straight finasteride converts dht into estrogen so your hairline is saved from it? correct?

 

[krishna]

yea i was using .5 mg adex ed but it wasn't enough so I added 20 mg nolva ed.



so let me get the science straight finasteride converts dht into estrogen so your hairline is saved from it? correct?

Haha....I've been trying to straighten out people's biochemisty on hair loss all day (not just this thread)! Finasteride does not convert dht into estrogen. What finasteride does, is inhibit the 5-AR enzyme. This enzyme is responsible for reducing testosterone into dht. If you neutralize the enzyme, then none of your testosterone will convert to dht. This means more of it will convert to estrogen instead, unless of course you're using arimidex as well.

 

[tommboy]

How much percent of test is DHT, so I can see how much of my test cyp is not being used (for the sake of my hair)

 

[krishna]

How much percent of test is DHT, so I can see how much of my test cyp is not being used (for the sake of my hair)

0% of test is dht, they are different compounds. I'm not sure what your question is. Test converts to dht, but they are not the same thing. Test is test, and dht is dht. If you're asking how much of your test converts to dht, then there's no way to really answer that question without blood tests.

 

[tommboy]

I was wandering if DHT played a big role in gains (muscle and strength wise) moreover will finasteride hurt gains? and how much