Please Scroll Down to See Forums Below 
tatman3177
New member
another interesting find from another site..
A new study is revolutionary. For a long time, it has been said that test/deca/eq/tren are anabolic receptor agonists (that is, they act on the anabolic receptor), while dbol/winny/drol are not anabolic receptor agonists, but act through other mechanisms like nitrogen retention and glucocorticoid receptors to increase growth. The reason for these beliefs was that in test tubes, the injectables attach to the anabolic receptors, while the orals usually don't.
In "stacking", people would stack an AR drug (like deca) with a non-AR drug (like dbol). And it was certainly believed that without action at the anabolic receptor, dbol-only cycles were believed to be worthless.
This new study shows that in life, versus in test tubes, dbol and winny are strong activators of the anabolic receptor! Dbol only cycles do make sense for beginners! All steroids may now be considered to be essentially the same in mechanism of action!
J Steroid Biochem Mol Biol. 2005 Apr;94(5):481-7. Epub 2005 Mar 17. Related Articles, Links
Anabolic-androgenic steroid interaction with rat androgen receptor in vivo and in vitro: A comparative study.
Feldkoren BI, Andersson S.
Departments of Obstetrics-Gynecology and Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9032, USA.
Anabolic steroids are synthetic derivatives of testosterone and are characterized by their ability to cause nitrogen retention and positive protein metabolism, thereby leading to increased protein synthesis and muscle mass. There are disagreements in the literature in regards to the interaction of anabolic steroids with the androgen receptor (AR) as revealed by competitive ligand binding assays in vitro using cytosolic preparations from prostate and skeletal muscle. By use of tissue extracts, it has been shown that some anabolic steroids have binding affinities for the AR that are higher than that of the natural androgen testosterone, while others such as stanozolol and methanedienone have significantly lower affinities as compared with testosterone. In this study we show that stanozolol and methanedienone are low affinity ligands of the rat recombinant AR as revealed by a ligand binding assay in vitro, however, based on a cell-based AR-dependent transactivation assay, they are potent activators of the AR. We also show that a single injection of stanozolol and methanedienone causes a rapid cytosolic depletion of AR in rat skeletal muscle. Based on these results, we conclude that anabolic steroids with low affinity to AR in vitro, can in fact in vivo act on the AR to cause biological responses.
__________________
A new study is revolutionary. For a long time, it has been said that test/deca/eq/tren are anabolic receptor agonists (that is, they act on the anabolic receptor), while dbol/winny/drol are not anabolic receptor agonists, but act through other mechanisms like nitrogen retention and glucocorticoid receptors to increase growth. The reason for these beliefs was that in test tubes, the injectables attach to the anabolic receptors, while the orals usually don't.
In "stacking", people would stack an AR drug (like deca) with a non-AR drug (like dbol). And it was certainly believed that without action at the anabolic receptor, dbol-only cycles were believed to be worthless.
This new study shows that in life, versus in test tubes, dbol and winny are strong activators of the anabolic receptor! Dbol only cycles do make sense for beginners! All steroids may now be considered to be essentially the same in mechanism of action!
J Steroid Biochem Mol Biol. 2005 Apr;94(5):481-7. Epub 2005 Mar 17. Related Articles, Links
Anabolic-androgenic steroid interaction with rat androgen receptor in vivo and in vitro: A comparative study.
Feldkoren BI, Andersson S.
Departments of Obstetrics-Gynecology and Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9032, USA.
Anabolic steroids are synthetic derivatives of testosterone and are characterized by their ability to cause nitrogen retention and positive protein metabolism, thereby leading to increased protein synthesis and muscle mass. There are disagreements in the literature in regards to the interaction of anabolic steroids with the androgen receptor (AR) as revealed by competitive ligand binding assays in vitro using cytosolic preparations from prostate and skeletal muscle. By use of tissue extracts, it has been shown that some anabolic steroids have binding affinities for the AR that are higher than that of the natural androgen testosterone, while others such as stanozolol and methanedienone have significantly lower affinities as compared with testosterone. In this study we show that stanozolol and methanedienone are low affinity ligands of the rat recombinant AR as revealed by a ligand binding assay in vitro, however, based on a cell-based AR-dependent transactivation assay, they are potent activators of the AR. We also show that a single injection of stanozolol and methanedienone causes a rapid cytosolic depletion of AR in rat skeletal muscle. Based on these results, we conclude that anabolic steroids with low affinity to AR in vitro, can in fact in vivo act on the AR to cause biological responses.
__________________
