I`ve ALWAYS thought about this but never did it. Say you`re curling 60 pound DB`s, the ones that have collars and you set up, but you put 35 pounds on one side and 20 pounds on the other, with the heavier side being on the inside of the dumbell. So when you curl you have to sort of rotate more toward the outside while going up because of the weight imbalance. just a thought.