cocaine

[juiceddreadlocks]

Are you sure you're not talking of plain amphetamine? It is a rather rare practice to administer meth consistently for motivation/concentration purposes, although not unheard of - it is just too 'intense' for basic mundane functioning.
Problem with aderall is the mix of l-amp salts which exert most of their effects via periphery - not pleasant. Dexedrine (pure d-amp) though gets rave reviews on task completion/focus/drive.

i thought adderrall had some dextro in it? i knew it was a mix of amphetamines.

 

[juiceddreadlocks]

No, not really. Spongebob is on the right track. Think of nicotine gum/patches and cigarettes. It is almost impossible to become addicted to gum/patch, whereas cigarettes are much different.

isnt there way less nicotine in the patch/gum? nictotine is probably the most amazing substance known to man, too bad we dont really have a good way to injest it.

 

[Optimus B]

isnt there way less nicotine in the patch/gum? nictotine is probably the most amazing substance known to man, too bad we dont really have a good way to injest it.

in the most potent versions of the patch, there's the equivalent amount of nicotine to 2.5 packs of cigarettes. it's time released though.

 

[juiceddreadlocks]

in the most potent versions of the patch, there's the equivalent amount of nicotine to 2.5 packs of cigarettes. it's time released though.

sorry, i should have just said the gum, im not up on how much nicotine was in the patch.

 

[hardrock]

Fun to do when partying sometimes, but the comedown is a bitch. Especially if there's no booze left. Shitty drug overall. 5 minute high that just leaves you wanting more. Only good for when you're so drunk you can't think or walk straight. A little bump and you feel sober again. haven't touched it in a long time tho.

 

[sparky_d2]

Fun to do when partying sometimes, but the comedown is a bitch. Especially if there's no booze left. Shitty drug overall. 5 minute high that just leaves you wanting more. Only good for when you're so drunk you can't think or walk straight. A little bump and you feel sober again. haven't touched it in a long time tho.

No doubt!!! This is by far the worst drug when it comes to "coming down". You feel all sad and depressed and shit. If fucks with your mind. Better to get beer and lots of food for the come down.

 

[juve]

the reason for all that being that it is more suitable to cross the BBB given how its been modified.

its my understanding the effects of meth arent almost purely 5-ht mediated, and if they were i dont understand how they could also have much to do with GABA since they arent even the same receptor type(2nd messenger) and GABA is inhibitory (cl- channel). the effects of amphetamines and cocaine to some extent are to block DA reuptake at the synapse, although dextro is said to increase transmission by some means, either synthesis of synaptic vessicles or something...

the effects of amphetamines in the CNS are to increase dopamine transmission especially in the frontal and pre-frontal cortex, for most people it gives them an edge, for people with decreased development in the PFC (some ADD cases) it just brings them up to normal.


i totally agree with you about alcohol.

GABA-B subunits are activated by cocaine and exhbit inhibtory effect on GABA release, plus the activation of GABA-A1 sub-units could partially account for cocaine's ability to give mental edge while relieving anxiety and maintaining mental accuity without lapsing into distress, and such as usually happens with stimulants.
And yes, adderall is a mix of l-and d-amp salts - but l-amp is pretty much useless if not 'harmful' for the purposes intended.
While meth and amp are similar structurally and in their effects, they do exhibit distinct disparities being that meth is more potent and centrally activated. Also meth is quite excitoxic exhibiting high glutamate spikes in various parts of the brain, whereas coke and amp to a much lesser degree.

 

[BrothaBill]

To the fastest way Iv or smoking, I dont think the second or so difference makes much difference. Smoking is slightly faster as it hits the lungs it goes directly to the left heart which pumps to the body. IV goes to the right heart with the deoxygenated blood and then to the lungs where the blood is reoxygenated, then onto the left side of the heart and up the aorta and the carotids to the brain. Just a slightly quicker route.
As to the disadvantages of smoking, you waste some in the form of smoke and the IV is full strength, IV users can get an infection of the heart called endocarditis usually the right heart b/c youre injecting bacteria with your drug. So its a risk someone takes.
Cocaine from what Ive studied is a strong psychological addiction and not physical like heroin, ie the physical withdrawal of opiates. Alcohol is the only drug that the withdrawals can kill you usually from repeated seizures.
I think that coke sux and its illegal to boot but I wasnt always an angel when younger so I have no room to talk. I dont think the risks of use justify the risks of it all and besides its too damn expensive b/c it only last a short period.

 

[KillahBee]

Fun to do when partying sometimes, but the comedown is a bitch. Especially if there's no booze left. Shitty drug overall. 5 minute high that just leaves you wanting more. Only good for when you're so drunk you can't think or walk straight. A little bump and you feel sober again. haven't touched it in a long time tho.

also a very good drug to have on hand for the super hot coke sluts

 

[juiceddreadlocks]

GABA-B subunits are activated by cocaine and exhbit inhibtory effect on GABA release, plus the activation of GABA-A1 sub-units could partially account for cocaine's ability to give mental edge while relieving anxiety and maintaining mental accuity without lapsing into distress, and such as usually happens with stimulants.

ill have to respond to this when i get home and review my notes from neurodevelopment and pathology

While meth and amp are similar structurally and in their effects, they do exhibit distinct disparities being that meth is more potent and centrally activated. Also meth is quite excitoxic exhibiting high glutamate spikes in various parts of the brain, whereas coke and amp to a much lesser degree.

what does meth do to cause glutamate spikes?