Clenbuterol No response? Possible mechanisms

[revolutionofthemind]

Any Physiologists or biochemists in the house?

My rat recently ran clenbuterol pyramiding up to 160mcg daily and had no response, having obtained the clen from previously reliable sources. Said rat is having problems getting rid of the last subcutaneous abdominal fat despite a clean low carb high protein diet as tracked by software. Said rat is also recovering from PTSD, or Post Traumatic Stress Disorder. Rat's understanding is that this is a disorder where the body is flooded with adrenaline and to a lesser degree Norepinephrine. Is it possible that the beta receptors are so downregulated from the PTSD issue as to cause a no response from the clenbuterol? Second, is there a way to overcome this? I know the ketotifen is often used with Clen to keep the beta receptors refreshed, but would this be effective if there is already significant downregulation of the beta receptors from endogenous excessive adrenaline? Would Yohimbine be of any use in this case? Are there other solutions to this problem?

 

[SouthernLord]

I'm a Brochemist


How are you cycling the clen?

No headaches, tremors, or cramps?

Your PTSD and receptor down regulation sounds like a solid theory for why you are not responding.

 

[ALIN]

Any Physiologists or biochemists in the house?

My rat recently ran clenbuterol pyramiding up to 160mcg daily and had no response, having obtained the clen from previously reliable sources. Said rat is having problems getting rid of the last subcutaneous abdominal fat despite a clean low carb high protein diet as tracked by software. Said rat is also recovering from PTSD, or Post Traumatic Stress Disorder. Rat's understanding is that this is a disorder where the body is flooded with adrenaline and to a lesser degree Norepinephrine. Is it possible that the beta receptors are so downregulated from the PTSD issue as to cause a no response from the clenbuterol? Second, is there a way to overcome this? I know the ketotifen is often used with Clen to keep the beta receptors refreshed, but would this be effective if there is already significant downregulation of the beta receptors from endogenous excessive adrenaline? Would Yohimbine be of any use in this case? Are there other solutions to this problem?

Did you 'feel' anything from the CLEN?
Increased heart rate?? Energy?? Shakes??

 

[st8grad]

How is your fat intake on low carb - high protein diet? You need to get that fat intake up on a low carb.

Is said rat taking other medications for PTSD? Ketotifen is supposed to help and I'm not sure if beta receptors down regulate from endogenous hormones.

Cortisol may be a likely suspect in this equation. Herbally, L-Theanine is awesome for reducing anxiety/stress while promoting alertness. Mixed with Kava or Valerian it's more effective at reducing anxiety, but you get the drowsiness.

Good luck dude.

 

[KenBraggofCarroltonGA]

rat with ptsd may not want to do clen

 

[revolutionofthemind]

How is your fat intake on low carb - high protein diet? You need to get that fat intake up on a low carb.

Is said rat taking other medications for PTSD? Ketotifen is supposed to help and I'm not sure if beta receptors down regulate from endogenous hormones.

Cortisol may be a likely suspect in this equation. Herbally, L-Theanine is awesome for reducing anxiety/stress while promoting alertness. Mixed with Kava or Valerian it's more effective at reducing anxiety, but you get the drowsiness.

Good luck dude.

Did you 'feel' anything from the CLEN?
Increased heart rate?? Energy?? Shakes??

Yeah there was the typical hand trembling/shaking the first day or two.

Fat intake was around 40grams total.

Only other med is Wellbutrin, which should also increase the activity of norephinephrine by preventing it's reabsorbtion.

Haven't ran any clen in well over a year. Rat started with a dose of 25 mcg first day to ensure that product wasn't overdosed or have other issues. Dosage was ramped up to 160 mcg daily over a period of one week. Ran that dosage for two weeks and then discontinued due to non response.