Celebrex

[enacer420nj]

Anyone ever use Celebrex? My doc gave it to me for a partial tear in my back. Its an anti inflamatory...ive read not too good things about it.

 

[Ruca]

worked great for me a couple of years ago to get over a herniated disc in my lower back. no sides that I am/was aware of. you can also get similar results with high..800mg doses of ibuprofin.

 

[chris302001]

Anyone ever use Celebrex? My doc gave it to me for a partial tear in my back. Its an anti inflamatory...ive read not too good things about it.

The not too good things you've heard about it are unfounded because it belongs in the same group as Vioxx (Cox 2 inhibitors). It has not been shown to produce terrible side effects like Vioxx and has never been taken off the market.

The advantage of a Cox-2 inhibitor is that it only inhibits the Cox 2 enzyme. This enzyme is what you want to block to with regard to inflammation and pain.

Traditional NSAIDS like Ibuprofen, Aspirin, and Naprosyn/Aleive are nonselective cox inhibitors. They inhibit both cox 1 and cox 2 enzymes. The problem with blocking cox 1 enzymes are that you can develop gastric ulcers with long term use and that the cox 1 enzyme is also responsible in part for platelet aggregation and the clotting of blood. (That's why people who are worried about heart attacks take aspirin.)

Acetaminophen or paracetamol to those across the pond, which is not technically an NSAID, is believed to block the Cox 3 enzyme. This helps it interfere with the perception of pain, but it doesnt do anything to reduce inflamation.

 

[tbuzzell]

I also took it for a herniated disc for a couple years. I have a heart condition, which you are not suppose to take Celebrex if you do. However, the benefits far out weighed the side effects, which I did not have any. I was monitored by a cardiologist and was "safe" for me. My doc told me that it depends on how your body adjusts to the med. You know your body and need to listen to it.

 

[thelion2005]

The not too good things you've heard about it are unfounded because it belongs in the same group as Vioxx (Cox 2 inhibitors). It has not been shown to produce terrible side effects like Vioxx and has never been taken off the market.

The advantage of a Cox-2 inhibitor is that it only inhibits the Cox 2 enzyme. This enzyme is what you want to block to with regard to inflammation and pain.

Traditional NSAIDS like Ibuprofen, Aspirin, and Naprosyn/Aleive are nonselective cox inhibitors. They inhibit both cox 1 and cox 2 enzymes. The problem with blocking cox 1 enzymes are that you can develop gastric ulcers with long term use and that the cox 1 enzyme is also responsible in part for platelet aggregation and the clotting of blood. (That's why people who are worried about heart attacks take aspirin.)

Acetaminophen or paracetamol to those across the pond, which is not technically an NSAID, is believed to block the Cox 3 enzyme. This helps it interfere with the perception of pain, but it doesnt do anything to reduce inflamation.

Agree.
I'm using it now to cut the pain from my hip.
But ... I would not want to use it over a long period of time.

 

[lanky]

you will probably be put on celebrex after surgery , like 6-8 hours after your last dose of toradol.