Start off with 0.1 mg twice a day for two weeks, then re-check your blood pressure. If you need more, go slow and in small increments -- 0.1 mg per day. Give two weeks between each dosage adjustment for the effect to stabilize. Also, if you end up taking more than say 1 mg per day, don't stop taking it abruptly because you may develop rebound hypertension. It needs to be tapered off if you have built up to a high dose. I would recommend you do some more research into the drug before starting it. It acts mostly in the brain stem to produce its effect, and it's a potent, excellent drug, but it can have some side effects you should look into, most notably dry mouth, dizziness, depression, nervousness. When taken acutely it stimulates GH release, but over any sustained dosing this effect disappears. I doubt it would be worth taking this drug for the GH effect, but it's a good antihypertensive.