Yes bro. If u do slin like how a pro BB does which resembles a real Daibetic like 3 times a day. it can make u insulin resistant. When your body sees too much insulin in your system it will make your cells resistant to insulin but instead will shift the carbs to adipose tissues making u fat. But take insulin only after excercise due to its excellent source of blunting Cortisol and thats when muscle cells are hungry and absorbs anythig like a sponge. Make sure u have ala and chrom picolinate to keep cells sensitive to slin.