It's actually supposed to do the opposite and make you "feel good". just a good mood in general, increased libido, etc. i was on test/tren/deca/dbol, letro at 2.5mg every 3rd day, it killed my libido and dostinex @ .5mg every 4th day simply put my libido back to normal. i think if i didnt run the letro, my libido would be "higher" then normal range, lol. but i wont run tren or deca without it, .5mg every 3rd or 4th day will be fine or twice a week. and to answer your main question, no, i did NOT notice any more depression then normal.