Please Scroll Down to See Forums Below
Bromo question
- Thread starter Canuck4
- Start date
This website says 3 hours...............??????
Pharmacokinetics: Although 28% of an orally administered dose of bromocriptine is absorbed across the GI tract, only 6% reaches the circulation due to significant hepatic metabolism. Oral administration of a single 1.25-5.0 mg dose results in serum prolactin reductions within 2 hours. Bromocriptine therapy produces maximal reductions in the serum prolactin levels of hyperprolactinemic patients within 4 weeks and significantly reduces growth hormone levels in acromegaly patients within 1-2 hours. The drug binds extensively (90-96%) to serum albumin and does not appear to distribute into erythrocytes. More than 90% of an absorbed dose undergoes first-pass metabolism, with the remainder of the dose hydrolyzed in the liver to inactive metabolites. Bromocriptine has a half-life of 3 hours. Metabolites are eliminated in the bile, with only a small amount excreted by the kidneys.
http://www.parkinsons-information-exchange-network-online.com/drugdb/020.html
Pharmacokinetics: Although 28% of an orally administered dose of bromocriptine is absorbed across the GI tract, only 6% reaches the circulation due to significant hepatic metabolism. Oral administration of a single 1.25-5.0 mg dose results in serum prolactin reductions within 2 hours. Bromocriptine therapy produces maximal reductions in the serum prolactin levels of hyperprolactinemic patients within 4 weeks and significantly reduces growth hormone levels in acromegaly patients within 1-2 hours. The drug binds extensively (90-96%) to serum albumin and does not appear to distribute into erythrocytes. More than 90% of an absorbed dose undergoes first-pass metabolism, with the remainder of the dose hydrolyzed in the liver to inactive metabolites. Bromocriptine has a half-life of 3 hours. Metabolites are eliminated in the bile, with only a small amount excreted by the kidneys.
http://www.parkinsons-information-exchange-network-online.com/drugdb/020.html
W
WARBIRDWS6
Guest
PEAK: 1-2 hours
DURATION: 4-8 hours
Half-Life: 50 hours
so i'd say twice a day is optimal.....but since the half life is 2 days, there should be no major problem with EOD. just take 5mg ED.....if you have enough caps and it doesn't make you nauseous. that would be my choice.
DURATION: 4-8 hours
Half-Life: 50 hours
so i'd say twice a day is optimal.....but since the half life is 2 days, there should be no major problem with EOD. just take 5mg ED.....if you have enough caps and it doesn't make you nauseous. that would be my choice.
Last edited:
