Aromasin long term tolerance

[madbro]

Can your body develop tolerance to long term aromasin usage? Hence making it less effective in the long run?

 

[madbro]

The reason I ask this is because someone has complained about developing tolerance to AI"s... Arimidex, Aromasin or Letrozole?

 

[musclei]

I wonder about this as well since I blast and cruise and need the Aromasin to keep aromatisation at bay. Knowing how it works I would say you can't develop a tolerance for it since it doesn't even act on yourself but your hormones. I wonder about the side effects in the long term as well but I hear it's a pretty modern drug so you can't know for sure.

 

[bigbassturd]

Aromasin is a suicide inhibitor, it binds to the estro and kills it, and dies in the process. Estrogen will not adapt or 'learn' a way to stop being killed by a suicide AI

 

[madbro]

I read about atleast 3 people on the internet claiming exemstane stopped working for them at some point..
so they changed to a more dangerous AI like letrozole..

It doesnt binds to estrogen you brofessor... It binds to the aromatase enzyme and destroys it..
Human body organism always trys to adapt so it might aswell produce in long term way more of this enzyme then necessary.. same shit happens with everydrug lol... works temporary then bam body adapts..

 

[ballslee]

I do think your body can get more used to a dosage protocol though.
I started taking 12.5 EOD, then went to 12.5 Ed, and now im at 25 ED.....

I don't think your body can get a tolerance to it long term, but it could require higher dosages depending on the amount of estrogen, etc

 

[bigbassturd]

I read about atleast 3 people on the internet claiming exemstane stopped working for them at some point..
so they changed to a more dangerous AI like letrozole..

It doesnt binds to estrogen you brofessor... It binds to the aromatase enzyme and destroys it..
Human body organism always trys to adapt so it might aswell produce in long term way more of this enzyme then necessary.. same shit happens with everydrug lol... works temporary then bam body adapts..

No shit? I didn't know, it's my first day here.

I know what it binds to, I'm just driving down the highway and didn't see a need to go into depth of how aromatization takes place, but since you think being a smartass and fucking name calling is a little better method, we'll take your way.

Third-generation AIs are specific for the aromatase enzyme. Aromatase inhibitors block the conversion of androgens to estrogens via the aromatase enzyme, resulting in up to a 95% decrease in endogenous estrogen levels. This is different from nolva, which blocks estrogen's effect via competitive inhibition of estrogen binding to ERs and an antagonist (and agonist) for ER and down-regulates expression of genes controlled by ER expression.

Exemestane, a steroidal inhibitor that is a structural derivative of androstenedione (the substrate of aromatase), irreversibly inhibits the aromatase enzyme. In contrast, the nonsteroidal compounds letrozole and anastrozole reversibly bind to the aromatase enzyme.

 

[bigbassturd]

I do think your body can get more used to a dosage protocol though.
I started taking 12.5 EOD, then went to 12.5 Ed, and now im at 25 ED.....

I don't think your body can get a tolerance to it long term, but it could require higher dosages depending on the amount of estrogen, etc

You don't get a 'tolerance' so to speak, if you need more for a higher level of estrogen

Kind of what I was trying to say before this thread turned smartass.

Obviously a man taking 500mg of test per week isn't going to have the same levels of aromatization occur as if he were to be taking 1gram a week. Hence the need for a stronger aromatose inhibitor like letrozole, or a higher dose of a steroidal suicide inhibitor such as exemestane.