smtimelevi said:
MOD EDIT - please read the rules - you cant post source links
OK Fine-
Letrozole is the only pharmacological “cure” for gyno that I know of to have ever worked in bodybuilders. In a study conducted on rodents, Letrozole was able to effectively destroy breast tissue tumors (6), and it’s also been effective on many bodybuilders who have used it to eliminate an existing case of gynocomastia. In my case, I used Letro to get rid of my own gyno, by starting with a dose of 2.5mgs/day and then lowering it by .25mcgs per week once my symptoms abated.
With regards to using this stuff on a cycle, unless you are extremely gyno prone, or need to reduce estrogen levels to virtually nothing (for a bodybuilding contest or whatever), it’s going to be too powerful for most people. Male and female competitors typically use it to get the last bits of estrogen related water retention out of them during the final weeks of contest preparation. But when used on a typical cycle, Letro is generally overkill unless a ripped look with zero water and estrogen is desired or if the user is prone to gyno.
References:
1. Clin Cancer Res. 2005 Apr 15;11(8):2809-21.
2. Epilepsy Behav. 2004 Apr;5(2):260-3
3. J Clin Endocrinol Metab. 2005 Oct;90(10):5717-22. Epub 2005 Jul Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibition. T'Sjoen GG, Giagulli VA, Delva H, Crabbe P, De Bacquer D, Kaufman JM.
4. Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267[Letrozole], in healthy male subjects PF Trunet, P Mueller, AS Bhatnagar, I Dickes, G Monnet and G White Research and Development Department, CIBA-GEIGY Limited, Basel, Switzerland>.
5. Clin Cancer Res. 2003 Jan;9(1 Pt 2):468S-72S. Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
6. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):27-34. Aromatase overexpression transgenic mice model: cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiology