Please Scroll Down to See Forums Below
Arimidex, Femara, Armasin -- any of these have liver toxic properties?
- Thread starter Whacked
- Start date
Güclü_oglan
New member
i'm pretty sure they don't. I know nolvadex don't and arimidex as well
hugeskinny
New member
"Arimidex’ must not be taken by patients with certain disorders or diseases which affect the liver or kidneys"
Correct me if I'm wrong, this suggests it may affect liver/kidney values if you have existing problems.
Correct me if I'm wrong, this suggests it may affect liver/kidney values if you have existing problems.
macrophage69alpha
New member
tamoxifen is hepatoxic.
though here is an interesting study
Clin Chim Acta. 2006 Feb 23; [Epub ahead of print] Related Articles, Links
Attenuation of tamoxifen-induced hepatotoxicity by taurine in mice.
Tabassum H, Rehman H, Banerjee BD, Raisuddin S, Parvez S.
Immunotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110 062, India; Department of Biochemistry, UCMS and G.T.B. Hospital, Dilshad Garden, New Delhi 110 095, India.
BACKGROUND: One of the most attractive approaches to disease prevention involves the use of natural antioxidants to protect tissue against toxic injury. We investigated the modulatory effects of exogenously administered taurine on the toxicity of the anticancer drug tamoxifen with special reference to protection against disruption of drug metabolizing and antioxidant enzymes in Swiss albino mice. METHODS: Male Swiss albino mice were divided into 4 groups. The extent of lipid peroxidation was evaluated in terms of thiobarbituric acid reactive substances formed. The following assays were performed in the hepatic tissue (a) antioxidant enzymes such as superoxide dismutase and catalase, (b) cytochrome P450 content, (c) glutathione-metabolizing enzymes such as glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glucose 6-phosphate dehydrogenase, and (d) low molecular weight antioxidants (reduced glutathione, ascorbic acid) and protein carbonyl content. RESULTS: Tamoxifen induced lipid peroxidation, protein carbonyl content and inhibited the enzymes of antioxidant defense system. It was also observed that the activities of antioxidant enzymes and glutathione-metabolizing enzymes were considerably stabilized in mice pretreated with taurine. CONCLUSION: Taurine protects the integrity of the hepatic tissue by stabilizing the reactive oxygen species mediated lipid peroxidation and protein carbonyl formation. Additionally taurine may prove to be efficacious as an antioxidant in tamoxifen-induced hepatotoxicity.
though here is an interesting study
Clin Chim Acta. 2006 Feb 23; [Epub ahead of print] Related Articles, Links
Attenuation of tamoxifen-induced hepatotoxicity by taurine in mice.
Tabassum H, Rehman H, Banerjee BD, Raisuddin S, Parvez S.
Immunotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110 062, India; Department of Biochemistry, UCMS and G.T.B. Hospital, Dilshad Garden, New Delhi 110 095, India.
BACKGROUND: One of the most attractive approaches to disease prevention involves the use of natural antioxidants to protect tissue against toxic injury. We investigated the modulatory effects of exogenously administered taurine on the toxicity of the anticancer drug tamoxifen with special reference to protection against disruption of drug metabolizing and antioxidant enzymes in Swiss albino mice. METHODS: Male Swiss albino mice were divided into 4 groups. The extent of lipid peroxidation was evaluated in terms of thiobarbituric acid reactive substances formed. The following assays were performed in the hepatic tissue (a) antioxidant enzymes such as superoxide dismutase and catalase, (b) cytochrome P450 content, (c) glutathione-metabolizing enzymes such as glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glucose 6-phosphate dehydrogenase, and (d) low molecular weight antioxidants (reduced glutathione, ascorbic acid) and protein carbonyl content. RESULTS: Tamoxifen induced lipid peroxidation, protein carbonyl content and inhibited the enzymes of antioxidant defense system. It was also observed that the activities of antioxidant enzymes and glutathione-metabolizing enzymes were considerably stabilized in mice pretreated with taurine. CONCLUSION: Taurine protects the integrity of the hepatic tissue by stabilizing the reactive oxygen species mediated lipid peroxidation and protein carbonyl formation. Additionally taurine may prove to be efficacious as an antioxidant in tamoxifen-induced hepatotoxicity.
macrophage69alpha
New member
hugeskinny said:
these affect drug clearance, what was found was 3 fold higher plasma levels of the drugs in cases.
there was also an increase in MILD adverse events (sweating, nausea, etc) in patients with hepatic impairment or renal insufficiency
Similar threads
