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captainahole
New member
Hey guys. Here's a really interesting read. I for one am very interested in this anyone had any experience or know of anyone whom has tried this. This is from another site.
Here's an excerpt from an interesting article by L. Rea, opinion?
"DES (1-3) IGF-1
(NOT THE SAME AS IGF-1)
Most athletes have heard of IGF-1 (Insulin like growth factor-1) and the amazing
anabolic effects it has been reported to have upon protein based tissue such as muscle.
Des (1-3) IGF-1 is over 10 times (1000%) more anabolic than IGF-1. Now that is
amazing!!
IGF-1 is actually produced from both Insulin and growth hormone in the liver and
other tissues. IGF-1 is made up of 70 amino acids in a chain. Well, when a clever chemist
removes the last 3 amino acids in the IGF-1 chain (the N-terminal tri-peptide) it becomes
Des (1-3) IGF-1 and 1000% plus more anabolic. Why?
IGF-1 circulates through our blood stream and tissue 24 hours a day, 7 days a
week. Unfortunately, most of the IGF-1 is inactive because it is bound by another protein
called (get this) IGF-1 Binding Protein-3, or IGF-1-BP-3 for short. Since bound
hormones can not fit into and trigger a receptor-site, the majority of circulating and
muscle IGF-1 can not trigger an anabolic stimulus. Like tons of cellulite in a porno movie
(who watches those?) there is little good stuff happening. However, when IGF-1 is
altered and becomes Des (1-3) IGF-1 the binding protein IGF-1-BP-3 can not bind to it
and it is totally active. Another reason Des (1-3) IGF-1 is so potent is its unique ability to
fit into lactic acid altered IGF-1 receptor sites. (YUP) When we train we burn
carbohydrates as a fuel to make cellular ATP. When cells switch to this ATP pathway,
the by-product is Lactic Acid. This is of course the cause of most of the burn we feel
during intense or higher rep sets. Well, the lactic acid build-up is called acidosis, and it
destroys the shape of some receptor-sites for period of time. Therefore some
anabolic/anti-catabolic hormones have difficulty merging with their respective receptor-
site and triggering a response (such as even unbound IGF-1). Not so with Des (1-3) IGF-
1, the super growth factor. It fits into the IGF-1 receptor-site even after acidosis. Des (1-
3) IGF-1 is unbound, over 10 times more potent than IGF-1, and it picks receptor-site
locks. Too bad it has only a few minute active-life.
Did you know that our body's make Des (1-3) IGF-1 naturally? Most un-informed
individuals claim other wise, but it is true. When an athlete trains lactic acid builds up in
muscle tissue. As we know, there is always IGF-1 / GH present in the blood stream and
tissues (including muscle) from prior work-outs and other metabolic factors. That lactic
acid burn triggers IGF-1/GH secretion from both prior and present work-outs.
Unfortunately, lactic acid destroys some of the IGF-1 present in muscles being trained.
But wait, this is good too!
Lactic acid also cuts (truncates) the last 3 amino acids off the 70 amino acid chain
of "some" of the surviving IGF-1 and creates Des (I-3) IGF-1. So acidosis increases
GH/IGF-1 production in the liver, "unbinds" IGF-1 locally in the muscle being trained
(burned), destroys some of the IGF-1, and converts some IGF-1 into Des (I-3) IGF-1.
Huh, good deal. And the synthetic form of this super anabolic stuff is beginning to show
up on the black market more frequently."
I think it's worth the convo.
Here's an excerpt from an interesting article by L. Rea, opinion?
"DES (1-3) IGF-1
(NOT THE SAME AS IGF-1)
Most athletes have heard of IGF-1 (Insulin like growth factor-1) and the amazing
anabolic effects it has been reported to have upon protein based tissue such as muscle.
Des (1-3) IGF-1 is over 10 times (1000%) more anabolic than IGF-1. Now that is
amazing!!
IGF-1 is actually produced from both Insulin and growth hormone in the liver and
other tissues. IGF-1 is made up of 70 amino acids in a chain. Well, when a clever chemist
removes the last 3 amino acids in the IGF-1 chain (the N-terminal tri-peptide) it becomes
Des (1-3) IGF-1 and 1000% plus more anabolic. Why?
IGF-1 circulates through our blood stream and tissue 24 hours a day, 7 days a
week. Unfortunately, most of the IGF-1 is inactive because it is bound by another protein
called (get this) IGF-1 Binding Protein-3, or IGF-1-BP-3 for short. Since bound
hormones can not fit into and trigger a receptor-site, the majority of circulating and
muscle IGF-1 can not trigger an anabolic stimulus. Like tons of cellulite in a porno movie
(who watches those?) there is little good stuff happening. However, when IGF-1 is
altered and becomes Des (1-3) IGF-1 the binding protein IGF-1-BP-3 can not bind to it
and it is totally active. Another reason Des (1-3) IGF-1 is so potent is its unique ability to
fit into lactic acid altered IGF-1 receptor sites. (YUP) When we train we burn
carbohydrates as a fuel to make cellular ATP. When cells switch to this ATP pathway,
the by-product is Lactic Acid. This is of course the cause of most of the burn we feel
during intense or higher rep sets. Well, the lactic acid build-up is called acidosis, and it
destroys the shape of some receptor-sites for period of time. Therefore some
anabolic/anti-catabolic hormones have difficulty merging with their respective receptor-
site and triggering a response (such as even unbound IGF-1). Not so with Des (1-3) IGF-
1, the super growth factor. It fits into the IGF-1 receptor-site even after acidosis. Des (1-
3) IGF-1 is unbound, over 10 times more potent than IGF-1, and it picks receptor-site
locks. Too bad it has only a few minute active-life.
Did you know that our body's make Des (1-3) IGF-1 naturally? Most un-informed
individuals claim other wise, but it is true. When an athlete trains lactic acid builds up in
muscle tissue. As we know, there is always IGF-1 / GH present in the blood stream and
tissues (including muscle) from prior work-outs and other metabolic factors. That lactic
acid burn triggers IGF-1/GH secretion from both prior and present work-outs.
Unfortunately, lactic acid destroys some of the IGF-1 present in muscles being trained.
But wait, this is good too!
Lactic acid also cuts (truncates) the last 3 amino acids off the 70 amino acid chain
of "some" of the surviving IGF-1 and creates Des (I-3) IGF-1. So acidosis increases
GH/IGF-1 production in the liver, "unbinds" IGF-1 locally in the muscle being trained
(burned), destroys some of the IGF-1, and converts some IGF-1 into Des (I-3) IGF-1.
Huh, good deal. And the synthetic form of this super anabolic stuff is beginning to show
up on the black market more frequently."
I think it's worth the convo.
