I've talked to a doctor about this, and his advice was to NOT take it mid cycle. He claimed that while HCG would help with atrophy it would eventually cause futher supression of the HPTA so that it would be harder to recover at the end of the cycle. His advise was to use Arimidex daily at 1mg per 500mg of test per week. Supposedly, estrogen suppression will help HPTA suppression.