I have experienced both depression and anxiety for about 2 years. I have been homicidal, suicidal, all that crap. I even spent some time instutionalized. I know that it is due to a chemical inbalance brought apon by drug use (Rolls, Yeay, and K). Believe it or not, I am back on the juice and building my body rather then taring it down. I am on my second cycle this year and I am up to 230lbs at 5'11" I think that I am around 15% body fat so, I look like a cambell's soup kid(Cambell's will be sending you a letter next week George). Long story short, I am not experiencing any sort of depression or anxiety since being back into the gear. I am on Zoloft 150mg a day. It doesn't interfere with anything. I am sure that when I am bridging, I will experience some depression but, as long as IP keeps up their Anavar, I will not fall that far. Does anyone know of any drug interactions that I should watch out for, the doc wants me to take some anti-psychotics, don't know if I want to or not.