Antibiotics and AAS

[enacer420nj]

I am currently on week 15 of my 18 week cycle.
Wk1-18 EQ600
Wk5-18 TestE250
Wk16-18 Winny Tabs 50mg ED

PCT
HCG 1,000iu E3D x 3 weeks
Nolva 40mg ED for 10 days, 20mg ED x 2weeks after..
AIFM

I have to start Biaxin which is a 2 week antibiotic for a sinus infection, im also about to start my winny soon....Will this hinder my gains at all????

 

[mobro]

good question. i was always told it would.

 

[enacer420nj]

If it does maybe I should tought out the cold...and save the antibiotics for my PCT lol

 

[enacer420nj]

^bump

 

[todoveritas]

Biaxin (clarithromycin) is a semi-synthetic macrodlide antibiotic. It exerts its antibacterial effects by binding to the 50S ribosomal subunit of susceptible microorganisms resulting in inhibition of protein synthesis. The key is whether this protein inhibition occurs in mamnmlian mitochondrial protein synthesis similar to that seen with chloramphenicol and tetracycline.

A recent study comparing the extent of inhibition was conducted and found that of the various antibiotic categories, the macrolide class of antibiotics, of which Biaxin is a member, did not significantly inhibit mamalian protein synthesis.

For more detail cut and paste the following: aac.asm.org/cgi/reprint/50/6/2042.pdf

 

[Pat_McCrotch]

Your fine. The only way it will inhibit gains is not training hard because your sick.

 

[enacer420nj]

Biaxin (clarithromycin) is a semi-synthetic macrodlide antibiotic. It exerts its antibacterial effects by binding to the 50S ribosomal subunit of susceptible microorganisms resulting in inhibition of protein synthesis. The key is whether this protein inhibition occurs in mamnmlian mitochondrial protein synthesis similar to that seen with chloramphenicol and tetracycline.

A recent study comparing the extent of inhibition was conducted and found that of the various antibiotic categories, the macrolide class of antibiotics, of which Biaxin is a member, did not significantly inhibit mamalian protein synthesis.

For more detail cut and paste the following: aac.asm.org/cgi/reprint/50/6/2042.pdf

Thank you Mr Wizard lol....guess im good to go....i dont need anything fucking me up before my winny when beach season has begun....

 

[littleb]

You will be fine taking antibiotics bro... done it a few times...

the only bad part i ever felt was an upset stomach -- hence harder to down the cals. I wanted too...

Even if it did slightly hinder gains, if a doc gives you antibiotics, you prob need em.. [infections no matter how minor nothing too mess with]

Example -- I recently had minor minor procedure to remove ingrown toe nail, doc gave me an antibiotic to take just in case,,,,,, I of course figured ahhh Ill save em for later use.

Bad idea had to have my friggin toe lanced because infection set in and started to spread....... IV drip of antibiotics, sliced open toe,, because i figured i didnt need em... all over an ingrown toe nail lol...

If doc gives em too you take em... dont learn the hard way...

 

[bigrand]

Biaxin (clarithromycin) is a semi-synthetic macrodlide antibiotic. It exerts its antibacterial effects by binding to the 50S ribosomal subunit of susceptible microorganisms resulting in inhibition of protein synthesis. The key is whether this protein inhibition occurs in mamnmlian mitochondrial protein synthesis similar to that seen with chloramphenicol and tetracycline.

A recent study comparing the extent of inhibition was conducted and found that of the various antibiotic categories, the macrolide class of antibiotics, of which Biaxin is a member, did not significantly inhibit mamalian protein synthesis.

For more detail cut and paste the following: aac.asm.org/cgi/reprint/50/6/2042.pdf

They shouldnt affect human protein synth considering the differences in pro-K versus Eu-k ribosomes.... chloramphenicol and macros work through the 50s and tetra through the 30 which are unique to pro-k cells. Has there been evidence of tetra and chlor actually affecting eu-k ribosomes and prot synth?

Tetra and chlor are shitty drugs anyway....especially chlor....i have yet to see it used in my clinical rotations and dont expect to ever see it....too many sides and too many other much more effective drugs out there.

Be sure to take all your dose, especially with drugs that are generally bacteriostatic (macrolides are one group).

 

[todoveritas]

...Has there been evidence of tetra and chlor actually affecting eu-k ribosomes and prot synth?...

Wow, this is somewhat out of my field. I would assume that when you say eu-k, that you are referring to the eukaryotic translation process of mammalian protein synthesis?

I know there are studies showing inhibition of the binding of tRNA to ribosomes by tetracycline, but whether these findings were predicted based on structurally similar E. Coli and then inferred for mammalian processes, or whether they reflected actual studies involving eu-k, I don't really know.

Good question!

 

[pstate]

damn im on tetracycline indefinetly, and it destroyed protien synthesis in that study, i think ill get off and try accutane

 

[bigrand]

Wow, this is somewhat out of my field. I would assume that when you say eu-k, that you are referring to the eukaryotic translation process of mammalian protein synthesis?

I know there are studies showing inhibition of the binding of tRNA to ribosomes by tetracycline, but whether these findings were predicted based on structurally similar E. Coli and then inferred for mammalian processes, or whether they reflected actual studies involving eu-k, I don't really know.

Good question!

Yes, i was refering to eukaryotic ribosomes......the good thing about anti-bs that affect 30 and 50 ribosomal subunits and protein synth is that the 30 and 50S are in pro-k and not eu-k (70S i believe) and therefore do not inhibit protein synth in humans, only the bacteria that infect us......

 

[mobro]

well that's great! glad to hear my 30s are not in the same...........Right? LOL
i guess we all have specialties, but this dang sure "aint" mine.

 

[bigrand]

To the TS, no they wont hinder your gains directly. Macrolides interact with corticosteroids (increased pharm and toxic effects of the later), but not with anabolic/androgenic steroids...however, they both are metabolized in the liver and rarely there has been hepatotoxicity, so watch it while taking winny. The only thing that may affect your gains would b GI tract upset (N/V/D) but this is common with most if not all anti-bs.

 

[pstate]

To the TS, no they wont hinder your gains directly. Macrolides interact with corticosteroids (increased pharm and toxic effects of the later), but not with anabolic/androgenic steroids...however, they both are metabolized in the liver and rarely there has been hepatotoxicity, so watch it while taking Winstrol - stanozolol. The only thing that may affect your gains would b GI tract upset (N/V/D) but this is common with most if not all anti-bs.

okay so your saying tetracylcine does not affect protein synthesis in humans?

 

[bigrand]

okay so your saying tetracylcine does not affect protein synthesis in humans?

Nope.
Not to mention, when we talk about inhibiting protien synth in bacteria at the ribosomal level, we are talking about protiens for DNA replication and cell reproduction.... much different than protein synth in skeletal muscle.

 

[todoveritas]

No, his references are to Biaxin, a macrolide antibiotic. The gist of this thread is that tetracycline HAS been shown to inhibit mammalian protein synthesis in vitro (that means in "test-tube" studies) but not necessarily in humans. Bigrand is an expert in this field and probably can explain it much better than I.

 

[bigrand]

No, his references are to Biaxin, a macrolide antibiotic. The gist of this thread is that tetracycline HAS been shown to inhibit mammalian protein synthesis in vitro (that means in "test-tube" studies) but not necessarily in humans. Bigrand is an expert in this field and probably can explain it much better than I.

Well, not an expert, but quite interested....!

Correct, macrolides will not inhibit protein synthesis....but neither will any of the other drugs mentioned...in relation to what the thread starter wanted to know....protein synthesis in skeletal muscle and hindering of gains.

Tetracycline and to a greater extent chloramphenical and oxazolidinones (linezolid) inhibit human mitochondrial protein synthesis because their machinery is similar to prokaryotic ribosomes, there is a kind of cross binding......so human mitos cant replicate and then, neither can the cell.....thats why you can get aplastic anemia with chlor...the marrow supression since marrow is rapid reproducing.
But this is a different set of problems than what the TS wanted.
Your gains will be fine, but if you take LOTS of the three above drugs, you might get diseases steming from mitochondrial malfunction.

Thats the gist of the above posted link.....i knew chlor and oxazols did this, but not tetra, although its a shitty drug with lots of sides.......you would rarely see these effects with the typical tetra dose, and nobody uses chlor anymore.

Good read todo

 

[bigrand]

BTW, multisystem diseases caused by mito malfunction are QUITE rare....

 

[lanky]

I know of a person with a temperature of about 109.7 a few weeks back(the person passed away)..temp went from 104.7..4 hours later up to 109....was accurate constant monitoring with rectal probe(secondary verrified with head swipe thermometer & axilla) attached to cooling blanket machine,,,pt. was packed in ice, Tubed with AC settings ,neo drip -kept titrating up to an ungodly dose,,cant remenber if levophed drip was started , some sort of renal conduit surg two days proir, kidney draining pure pus when they opened the person up, propofol/and or versed,NSS, every anti B....

 

[bigrand]

I know of a person with a temperature of about 109.7 a few weeks back(the person passed away)..temp went from 104.7..4 hours later up to 109....was accurate constant monitoring with rectal probe(secondary verrified with head swipe thermometer & axilla) attached to cooling blanket machine,,,pt. was packed in ice, Tubed with AC settings ,neo drip -kept titrating up to an ungodly dose,,cant remenber if levophed drip was started , some sort of renal conduit surg two days proir, kidney draining pure pus when they opened the person up, propofol/and or versed,NSS, every anti B....

If the person was THAT septic, the norepi was probly started.....usually a last resort but heard of it being used a little more nowadays. Was the pathogen isolated? Probly the propofol/versed/fent ect. combo in there for the surgery......
Thats a nasty little story....i dont have any out of this world ones yet....give me a few years!

 

[enacer420nj]

I know of a person with a temperature of about 109.7 a few weeks back(the person passed away)..temp went from 104.7..4 hours later up to 109....was accurate constant monitoring with rectal probe(secondary verrified with head swipe thermometer & axilla) attached to cooling blanket machine,,,pt. was packed in ice, Tubed with AC settings ,neo drip -kept titrating up to an ungodly dose,,cant remenber if levophed drip was started , some sort of renal conduit surg two days proir, kidney draining pure pus when they opened the person up, propofol/and or versed,NSS, every anti B....

Way to hijack a thread...incase you havent realized this is EF not mdforum.com.....were talking about anti-biotics fucking up protein synthesis while on AAS....NOT a levorated hemothorax due to sebatical indofluxation of yousuckafuckingbigcockforpostingthatbullshit

 

[bigrand]

Way to hijack a thread...incase you havent realized this is EF not mdforum.com.....were talking about anti-biotics fucking up protein synthesis while on anabolic androgenic steroids....NOT a levorated hemothorax due to sebatical indofluxation of yousuckafuckingbigcockforpostingthatbullshit

You on tren?

 

[digit0x]

You on trenbolone?

har har i thought it was interesting.

 

[enacer420nj]

You on trenbolone?

No I just cant stand retards

 

[lanky]

Way to hijack a thread...incase you havent realized this is EF not mdforum.com.....were talking about anti-biotics fucking up protein synthesis while on anabolic androgenic steroids....NOT a levorated hemothorax due to sebatical indofluxation of yousuckafuckingbigcockforpostingthatbullshit

can i drink winny,,did brad pitt juice for fight club,,,what steroid will increase my fastball by 5 mph,

 

[ironclaw]

no, not at all, you'rre cool with it.