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Anti-e for D-bol

Aromaisn will work, but Femera is the best choice..... However, either of these might not be 100% effective since Dbol has a different aromatizing pathway..... I know only from personal EXP that Femera works pretty well with Dbol, just get a small bloat, but there is SOME bloat..... It is rather minimal though....

rizz
 
Prizz said:
Aromaisn will work, but Femera is the best choice..... However, either of these might not be 100% effective since Dbol has a different aromatizing pathway..... I know only from personal EXP that Femera works pretty well with Dbol, just get a small bloat, but there is SOME bloat..... It is rather minimal though....

rizz


Does femera KILL sex drive??
 
I think the problem with letro is that people use Waaaaay too much. 20mcg (yeah, micrograms) can lower estradiol by 30% and estrone by 60%...

Anyhoo... I found this out because I was working on something with Cy Wilson, and needed to look up something or other that he had said, and found that he actually posted something about 20mcg/day doses of Letro. I did the research, and lo and behold:


Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267[Letrozole], in healthy male subjects


PF Trunet, P Mueller, AS Bhatnagar, I Dickes, G Monnet and G White
Research and Development Department, CIBA-GEIGY Limited, Basel, Switzerland
.

The aim of this open, dose-finding study was to evaluate the effects of single dose CGS 20 267, a new oral nonsteroidal aromatase inhibitor, on the inhibition of estrogen production and also on the production of adrenal and testicular steroids in healthy male subjects. Nine dose levels ranging from 0.02-30 mg and placebo were tested, each dose being given to 3 subjects only. A total of 18 subjects were included; 12 of them received 2 single administration, the remaining 6 were exposed only once to one of the 2 highest dose levels. A reduction in serum estrogen levels when compared to baseline was already observed after 2 h, reaching maximum suppression between 10 and 48 h after administration. After 24 h, a suppression of estrone levels by 60-85% from baseline was achieved with all tested doses. A reduction in estradiol levels by about 30% from baseline was observed at the lowest dose (0.02 mg). This reduction was further enhanced dose dependently to a maximum of about 90% from baseline at 24 h after administration of the highest dose (30 mg). With the higher doses (10 and 30 mg), estrogen suppression was maintained up to 3 days. A dose-dependent increase of testosterone, LH, and FSH was observed and was most pronounced in the 10- and 30-mg dose groups, which can be considered as a consequence of the long-lasting aromatase inhibition achieved with these high doses. No effect on serum cortisol and aldosterone levels was observed up to the highest dose. No clinically relevant changes were observed in blood chemistry and hematology tests. The systemic and subjective tolerability of CGS 20 267 was good at all doses. This study has shown that CGS 20 267 is a well tolerated, potent, selective, and long-acting inhibitor of the aromatase enzyme after single administration.
 
I am going to use the Adex myself, and my cycle looks like yours.

Why the adex 2 weeks early? If it will make a diff I'll deff do that.
 
I would save the Nolva for Gyno issues and for your PCT. I'd stick with A-dex or aromasin. I usually use A-dex straight through a cycle and I get a minimal amount of bloating/water retention. try running at about .5 a day and see hwo it goes.

Oh yeah, I'm also curious to see who else pre-loads Adex/aromasin. I have never done that. Is there really that much of a difference?
 
Madman95 said:
What is the best anti-e to use to prevent water retenation with d-bol?
I am currantly running Dbol at 50mg a day and sust 250 e3d .....using aromasin and staying very dry and gyno free :)
 
aluv4speed said:
I am going to use the Adex myself, and my cycle looks like yours.

Why the adex 2 weeks early? If it will make a diff I'll deff do that.

it takes about two weeks for it to take full affect that's if you don't want any bloat or you can take with the first dose of d-bol and you will be able to tell when it kicks in
 
anthony roberts said:
I think the problem with letro is that people use Waaaaay too much. 20mcg (yeah, micrograms) can lower estradiol by 30% and estrone by 60%...

Anyhoo... I found this out because I was working on something with Cy Wilson, and needed to look up something or other that he had said, and found that he actually posted something about 20mcg/day doses of Letro. I did the research, and lo and behold:


Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267[Letrozole], in healthy male subjects


PF Trunet, P Mueller, AS Bhatnagar, I Dickes, G Monnet and G White
Research and Development Department, CIBA-GEIGY Limited, Basel, Switzerland
.

The aim of this open, dose-finding study was to evaluate the effects of single dose CGS 20 267, a new oral nonsteroidal aromatase inhibitor, on the inhibition of estrogen production and also on the production of adrenal and testicular steroids in healthy male subjects. Nine dose levels ranging from 0.02-30 mg and placebo were tested, each dose being given to 3 subjects only. A total of 18 subjects were included; 12 of them received 2 single administration, the remaining 6 were exposed only once to one of the 2 highest dose levels. A reduction in serum estrogen levels when compared to baseline was already observed after 2 h, reaching maximum suppression between 10 and 48 h after administration. After 24 h, a suppression of estrone levels by 60-85% from baseline was achieved with all tested doses. A reduction in estradiol levels by about 30% from baseline was observed at the lowest dose (0.02 mg). This reduction was further enhanced dose dependently to a maximum of about 90% from baseline at 24 h after administration of the highest dose (30 mg). With the higher doses (10 and 30 mg), estrogen suppression was maintained up to 3 days. A dose-dependent increase of testosterone, LH, and FSH was observed and was most pronounced in the 10- and 30-mg dose groups, which can be considered as a consequence of the long-lasting aromatase inhibition achieved with these high doses. No effect on serum cortisol and aldosterone levels was observed up to the highest dose. No clinically relevant changes were observed in blood chemistry and hematology tests. The systemic and subjective tolerability of CGS 20 267 was good at all doses. This study has shown that CGS 20 267 is a well tolerated, potent, selective, and long-acting inhibitor of the aromatase enzyme after single administration.
Am I understanding this correctly? You're suggesting that men with test levels 1000% higher or more would have the same results?
 
macrophage69alpha said:
aromasin, AIFM or letrozole (though there are potential libido issues as mentioned)



Potential libido issues with aromasin or just the letro?? even when running test???
 
Ulter said:
Am I understanding this correctly? You're suggesting that men with test levels 1000% higher or more would have the same results?

I keep reading my post over and can't find where I said anything vaguely resembling what you are asking me if I said.

In fact, I can't even find where I implied it.

I said people use too much letro.

Then I posted a study showing that 1/10th the lowest dose I've ever heard of anybody taking (.25mgs/day) would suppress estadiol in normal males by 30%.

How did you extrapolate anything that you just asked me if I said, from my words or from that study?
 
He is asking if it would lower a man's estrogen by 30% if indeed his estrogen (due to AS) was much higher than a normal man's. Call it 1000% higher.
 
steelmass said:
He is asking if it would lower a man's estrogen by 30% if indeed his estrogen (due to AS) was much higher than a normal man's. Call it 1000% higher.

Maybe he'll explain what he meant?

In that study, the dose used was about 10-11x lower than what I've ever heard of anyone using (it works out to less than a tenth of a ml of AG-guys Letrozle, I think)...so...I mean...I was just making the point that it's absurdly strong, nothing more...
 
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