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albuterol inhaler

conan1071 said:
say a friend of mine is taking this. what is the optimal amount for fat burning??

Won't work. The inhaler is not systemic. Get some tabs for "your friend" if you want to burn fat. 4mgs 3x per day.
 
st8grad said:
Won't work. The inhaler is not systemic. Get some tabs for "your friend" if you want to burn fat. 4mgs 3x per day.

i have to disagree. i have had success with both. have u ever used an inhaler b4 st8?
 
conan1071 said:
say a friend of mine is taking this. what is the optimal amount for fat burning??
albuterol is great for cutting. look around a little bit online, you'll find someone who carries a liquid suspension. the inhaler might work, but wouldn't you feel like a piece of shit when your buddy dies from an asthma attack because u stole all of his inhalers? :evil:
 
*slaps forehead*

Sigh...

(And why would one believe inhalation of a drug does not effect the entire system?)



:cow:
 
Well respectfully Samoth, an inhaled beta2 agonist like albuterol or even inhaled corticosteroid are considered a topical preparation. You inhale the medicine it affects the beta 1 & 2 receptors in the lungs and somewhat in the heart and would very minimally travel throughout the body if at all.

Also I believe the dosage for one puff of albuterol is 90mcg which is .09 milligrams. So compared to a 4mg tablet that you swallow and travels throughout the whole body, I think it isn't going to do, well, jack shit, for fat loss.

That is kind of the idea behind the inhaled medications. That and the quicker onset.

I do use an albuterol inhaler and have before playing sports or running for basically my entire life.

If I am wrong I digress. Now some people may have felt thermogenic on an inhaler, but I doubt it is doing what they think.

I wouldn't advise anyone trying to use the inhaler on multiple puffs to try and get up to 2 or 4mgs either. Tachycardia may be the least of your problems if you do.

*slaps ass cheeks*

samoth said:
*slaps forehead*

Sigh...

(And why would one believe inhalation of a drug does not effect the entire system?)



:cow:
 
st8grad said:
Well respectfully Samoth, an inhaled beta2 agonist like albuterol or even inhaled corticosteroid are considered a topical preparation. You inhale the medicine it affects the beta 1 & 2 receptors in the lungs and somewhat in the heart and would very minimally travel throughout the body if at all.

Also I believe the dosage for one puff of albuterol is 90mcg which is .09 milligrams. So compared to a 4mg tablet that you swallow and travels throughout the whole body, I think it isn't going to do, well, jack shit, for fat loss.

Your second paragraph is TCR. The dosage is the main factor in the oral v. inhaled preparations.

How much of the drug is still available after oral ingestion depends on a number of factors, but on a one-to-one basis, you'll get more drug in the body via inhalation than through the stomach and digestive system.

And to counter daswoll's post, I've had asthma my entire life and used albuterol for over 20 years and find no thermogenic properties whatsoever in daily inhaled doses of up to 1 mg. (Albuterol was discussed in terms of clenbuterol plenty, like, a decade ago on boards, but no one ever found any comparative value in it. Now, in the day and age of profitable supplement suppliers dominating internet message boards, all of a sudden albuterol is "in". The reason it's popular now is because it was marketed and pushed by supplement companies -- after all, they can't push clenbuterol, as it's not approved for use in the US, but conveniently, albuterol is. But, hey, thinking a supplement works is really more important than whether or not it actually does works. How do you think GNC stays in business all these years?)

Also, for those thinking of using inhalors, if you read the instructions, you'll note that you don't actually get 90 mcg in a puff -- rather, that's the amount released from the aerosol canister. It tells you approximately how much a person is expected to actually inhale through the mouthpiece... I want to say it's ~70 mcg, but I don't recall off hand.



:cow:
 
702daswoll1 said:
I use at least 20 puffs a day for the record. Would it burn fat at that dosage in your infinite wisdom sir?

I would say that if you are using that much for asthma, you need a control medicine. Clearly that's not the question though.

How much actually enters your bloodstream through that route is beyond me. How long you hold your breath, how constricted your lungs are, how much is expelled when you exhale are all valid points to consider.

There is the issue of beta receptor down-regulation. To me twenty puffs seems like a walloping dose of albuterol. But when I was younger I can clearly remember needing four puffs sometimes to get things under control.

To accurately figure your dose, you probably need one of those dry powder inhalers that don't use a propellant. Then I suppose you need to find a study or clinical trial that measures the amount of the drug in the bloodstream and compare that against the amount in the bloodstream via tablets.

Venturing to make a complete guess I would bet that the tablets are more effective for fat loss than the inhalation. So five puffs at a time is approx .35 milligrams.

The tablet is 4mg. Even if you lose half to digestion and some of the tablet being fillers or binders, then it would seem to be better than the inhaler even assuming that you absorb all .35mg into your bloodstream.
 
dose depends on inhaler obviously. the two scrip inhalers i have contain 8.5 & 17.5 grams of albuterol respectively. eahc is 200 metered sprays. do the math or the dose.

albuterol woll get in bloodstream from inhalation.
 
8AND20 said:
dose depends on inhaler obviously. the two scrip inhalers i have contain 8.5 & 17.5 grams of albuterol respectively. eahc is 200 metered sprays. do the math or the dose.

albuterol woll get in bloodstream from inhalation.

The 17.5 grams is the net weight of the canister. Here is a clip from the package insert from Proventil...generics should be the same.

HOW SUPPLIED PROVENTIL HFA (albuterol sulfate) Inhalation Aerosol is supplied as a pressurized aluminum canister with a yellow plastic actuator and orange dust cap each in boxes of one. Each actuation delivers 120 mcg of albuterol sulfate from the valve and 108 mcg of albuterol sulfate from the mouthpiece (equivalent to 90 mcg of albuterol base).
 
Inhalation Aerosol and Capsules for Inhalation: Because of its gradual absorption from the bronchi, systemic levels of albuterol inhalation aerosol are low after inhalation of recommended doses. Studies undertaken with four subjects administered tritiated albuterol resulted in maximum plasma concentrations occurring within 2 to 4 hours. Due to the sensitivity of the assay method, the metabolic rate and half-life of elimination of albuterol in plasma could not be determined. However, urinary excretion provided data indicating that albuterol has an elimination half-life of 3.8 hours. Approximately 72% of the inhaled dose is excreted within 24 hours in the urine, and consists of 28% as unchanged drug and 44% as metabolite.

Inhalation Solution: Studies in asthmatic patients have shown that less than 20% of a single albuterol dose was absorbed following either intermittent positive-pressure breathing (IPPB) or nebulizer administration; the remaining amount was recovered from the nebulizer and apparatus and expired air. Most of the absorbed dose was recovered in the urine 24 hours after drug administration. Following a 3-mg dose of nebulized albuterol in adults, the maximal albuterol plasma levels at 0.5 hours were 2.1 ng/ml (range, 1.4 to 3.2 ng/ml). There was a significant dose-related response in FEV1 (forced expiratory volume in 1 second) and peak flow rate. It has been demonstrated that following oral administration of 4 mg of albuterol, the elimination half-life was 5 to 6 hours.
 
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