Please Scroll Down to See Forums Below
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an alternative browser.
You should upgrade or use an alternative browser.
ALA question
- Thread starter Bramil
- Start date
I am pretty sure that ALA is used for type 2 diabetes but it is administered I.V. not orally. Not 100% sure on this though. I came across a study on it a while back. i will see If I can find it.
Gluccophage is
used for type II diabetics and insulin resistance, ALA can be used in its place although there haven't been any conclusive tests that I know of, and as far as doseages I use 500mg a day. My wife on the other hand is insulin resistant and has 2000mg of gluccophage perscribed to her by an endocrinologist. That's about all I can tell ya..
used for type II diabetics and insulin resistance, ALA can be used in its place although there haven't been any conclusive tests that I know of, and as far as doseages I use 500mg a day. My wife on the other hand is insulin resistant and has 2000mg of gluccophage perscribed to her by an endocrinologist. That's about all I can tell ya..
macrophage69alpha
New member
ala is a good supplement.. it will increase insulin sensitivity and is a great anti-oxident
macrophage69alpha said:ala is a good supplement.. it will increase insulin sensitivity and is a great anti-oxident
Thanks Macro.
gethard1: I did at first want to use gluccophage but for me hard to get too. while ALA i can get readily.
Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial.
Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W, Augustin HJ, Dietze GJ, Rett K.
Hypertension and Diabetes Research Unit, Max Grundig Clinic, Buhl and City Hospital, Baden-Baden, Germany. [email protected]
Alpha-lipoic acid (ALA), a naturally occuring compound and a radical scavenger was shown to enhance glucose transport and utilization in different experimental and animal models. Clinical studies described an increase of insulin sensitivity after acute and short-term (10 d) parenteral administration of ALA. The effects of a 4-week oral treatment with alpha-lipoic acid were evaluated in a placebo-controlled, multicenter pilot study to determine see whether oral treatment also improves insulin sensitivity. Seventy-four patients with type-2 diabetes were randomized to either placebo (n = 19); or active treatment in various doses of 600 mg once daily (n = 19), twice daily (1200 mg; n = 18), or thrice daily (1800 mg; n = 18) alpha-lipoic acid. An isoglycemic glucose-clamp was done on days 0 (pre) and 29 (post). In this explorative study, analysis was done according to the number of subjects showing an improvement of insulin sensitivity after treatment. Furthermore, the effects of active vs. placebo treatment on insulin sensitivity was compared. All four groups were comparable and had a similar degree of hyperglycemia and insulin sensitivity at baseline. When compared to placebo, significantly more subjects had an increase in insulin-stimulated glucose disposal (MCR) after ALA treatment in each group. As there was no dose effect seen in the three different alpha-lipoic acid groups, all subjects receiving ALA were combined in the "active" group and then compared to placebo. This revealed significantly different changes in MCR after treatment (+27% vs. placebo; p < .01). This placebo-controlled explorative study confirms previous observations of an increase of insulin sensitivity in type-2 diabetes after acute and chronic intravenous administration of ALA. The results suggest that oral administration of alpha-lipoic acid can improve insulin sensitivity in patients with type-2 diabetes. The encouraging findings of this pilot trial need to be substantiated by further investigations.
Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W, Augustin HJ, Dietze GJ, Rett K.
Hypertension and Diabetes Research Unit, Max Grundig Clinic, Buhl and City Hospital, Baden-Baden, Germany. [email protected]
Alpha-lipoic acid (ALA), a naturally occuring compound and a radical scavenger was shown to enhance glucose transport and utilization in different experimental and animal models. Clinical studies described an increase of insulin sensitivity after acute and short-term (10 d) parenteral administration of ALA. The effects of a 4-week oral treatment with alpha-lipoic acid were evaluated in a placebo-controlled, multicenter pilot study to determine see whether oral treatment also improves insulin sensitivity. Seventy-four patients with type-2 diabetes were randomized to either placebo (n = 19); or active treatment in various doses of 600 mg once daily (n = 19), twice daily (1200 mg; n = 18), or thrice daily (1800 mg; n = 18) alpha-lipoic acid. An isoglycemic glucose-clamp was done on days 0 (pre) and 29 (post). In this explorative study, analysis was done according to the number of subjects showing an improvement of insulin sensitivity after treatment. Furthermore, the effects of active vs. placebo treatment on insulin sensitivity was compared. All four groups were comparable and had a similar degree of hyperglycemia and insulin sensitivity at baseline. When compared to placebo, significantly more subjects had an increase in insulin-stimulated glucose disposal (MCR) after ALA treatment in each group. As there was no dose effect seen in the three different alpha-lipoic acid groups, all subjects receiving ALA were combined in the "active" group and then compared to placebo. This revealed significantly different changes in MCR after treatment (+27% vs. placebo; p < .01). This placebo-controlled explorative study confirms previous observations of an increase of insulin sensitivity in type-2 diabetes after acute and chronic intravenous administration of ALA. The results suggest that oral administration of alpha-lipoic acid can improve insulin sensitivity in patients with type-2 diabetes. The encouraging findings of this pilot trial need to be substantiated by further investigations.
macrophage69alpha
New member
it definitely affect insulin sensitivity.. the extreme middle of the night hunger on high doses is indicative of this..
It may be a wise idea to add some high dose biotin with ALA use, since some evidence points to interaction between these nutrients. Also, biotin is a known glucose modulator in humans, at a dose of around 5-10mg a day.
http://www.nutrition.org/cgi/content/full/127/9/1776
http://www.nutrition.org/cgi/content/full/127/9/1776
cockdezl said:It may be a wise idea to add some high dose biotin with ALA use, since some evidence points to interaction between these nutrients. Also, biotin is a known glucose modulator in humans, at a dose of around 5-10mg a day.
http://www.nutrition.org/cgi/content/full/127/9/1776
Dezl,when you say interaction,are you referring to possible potentiation of one anothers actions?
HUCK, the study showed (only in rats) that high dose lipoic acid reduces biotin-dependant enzymatic pathways, and that the administration of biotin corrects this alteration. The authors theorize that this may be due to either structural similarities or absorptive interference.
Since this study was performed in rats, this may not apply to humans, but since biotin is known to have glucose reducing properties independant of lipoic acid's mechanism, then the use of biotin may increase the effect of ALA.
Since this study was performed in rats, this may not apply to humans, but since biotin is known to have glucose reducing properties independant of lipoic acid's mechanism, then the use of biotin may increase the effect of ALA.
Awesome Dezl,I will run the two together then.Thanks my man.
I have been taking like 1200-1800 mgs/day of ALA for about 2 weeks now ..... it defintely feels like it has an effect, to me.
I find that I can eat fewer starchy carbs and not get as pissy about it (grrrrr).... it just sesm that my blood sugar is regulated better somehow.
Plus, I am lowering my fat, so that cools.
I would love to find a good layman's explantion of how like this whole glucose, sucrose, insulin (occuring naturally in your body), "insulin sensitivity" and stuff like ALA and insulin supplementation, work.
I would never like "do" insulin per se, but just knopwing how all this works (in a sort of smart-layman's terms) would be very very cool.
Anyone have any pointers?
(Please dont take the thread off track with my requests).
Once again, ALA seems to be very cool, to me at least, for several reasons.
I find that I can eat fewer starchy carbs and not get as pissy about it (grrrrr).... it just sesm that my blood sugar is regulated better somehow.
Plus, I am lowering my fat, so that cools.
I would love to find a good layman's explantion of how like this whole glucose, sucrose, insulin (occuring naturally in your body), "insulin sensitivity" and stuff like ALA and insulin supplementation, work.
I would never like "do" insulin per se, but just knopwing how all this works (in a sort of smart-layman's terms) would be very very cool.
Anyone have any pointers?
(Please dont take the thread off track with my requests).
Once again, ALA seems to be very cool, to me at least, for several reasons.
sk* said:does this mean u can get the slin gut from ALA?
is it as dangerous if you dont know what you are doing?
I dont think that its "slin gut" as much as it is "GH Gut".
And from what I know, ALA is no where NEAR as dangerous as slin is.
