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gUiLe
New member
I have been useing ALA at between 3 and 4 grams a day. I am
getting great results so far. I will not post too much since this
is only the start of my second week, but besides being in ketosis
even taking in carbs at 200+ grams per day, I DEFINATELY feel
an increase in my strength. I have heard (I think Rangerx posted)
that he read a lethal dose for a human was around 30 grams.
I would like to know where he read this. Since taking in 3 to 4
grams is still quite a bit of ALA, I started researching a bit. I found
this.
Biological effect: Lipoic acid is observed to be biologically active and can be used clinically at dosages as low as 0.14-0.28 milligrams/kilogram of body weight (i.e., mg/kg), which would be equivalent to 10-22 mg. in an average person. Toxicology: Small animals injected with 100-200 mg/kg (i.e., the human equivalent of 7,800 - 15,500 mg.) produced depressive symptoms with tonic-clonic convulsions. In mice the convulsive dosage for 50% is 140-180 mg/kg (i.e., the human equivalent of 11,000 - 15,000 mg.). In mice, the lethal dose for 50% was 160-275 mg/kg, (i.e., the human equivalent of 13,000 - 22,000 mg.).
There were no toxic effects in mice treated by injection for 40 days with 75 mg/kg (human equivalent 6,000 mg.) nor in rats treated by injection for 60 days with 15 mg/kg (human equivalent of 1,200 mg.) nor in guinea pigs injected for 20 days at 10 mg/kg (human equivalent of 800 mg.). Lipoic acid in 0.5% solution had no undesirable effect on the mucosa, serous membrane, endothelium, or subcutaneous and muscular membranes. "Lipoic acid is rapidly absorbed and eliminated from the organism and its accumulation is improbable." Intravenous administration of lipoic acid in high dosages in humans were "well tolerated".
g
getting great results so far. I will not post too much since this
is only the start of my second week, but besides being in ketosis
even taking in carbs at 200+ grams per day, I DEFINATELY feel
an increase in my strength. I have heard (I think Rangerx posted)
that he read a lethal dose for a human was around 30 grams.
I would like to know where he read this. Since taking in 3 to 4
grams is still quite a bit of ALA, I started researching a bit. I found
this.
Biological effect: Lipoic acid is observed to be biologically active and can be used clinically at dosages as low as 0.14-0.28 milligrams/kilogram of body weight (i.e., mg/kg), which would be equivalent to 10-22 mg. in an average person. Toxicology: Small animals injected with 100-200 mg/kg (i.e., the human equivalent of 7,800 - 15,500 mg.) produced depressive symptoms with tonic-clonic convulsions. In mice the convulsive dosage for 50% is 140-180 mg/kg (i.e., the human equivalent of 11,000 - 15,000 mg.). In mice, the lethal dose for 50% was 160-275 mg/kg, (i.e., the human equivalent of 13,000 - 22,000 mg.).
There were no toxic effects in mice treated by injection for 40 days with 75 mg/kg (human equivalent 6,000 mg.) nor in rats treated by injection for 60 days with 15 mg/kg (human equivalent of 1,200 mg.) nor in guinea pigs injected for 20 days at 10 mg/kg (human equivalent of 800 mg.). Lipoic acid in 0.5% solution had no undesirable effect on the mucosa, serous membrane, endothelium, or subcutaneous and muscular membranes. "Lipoic acid is rapidly absorbed and eliminated from the organism and its accumulation is improbable." Intravenous administration of lipoic acid in high dosages in humans were "well tolerated".
g
